Natural coniferous resin salve used to treat complicated surgical wounds: pilot clinical trial on healing and costs

Sipponen, Arno; Kuokkanen, Opri; Tiihonen, R.; H, Kauppinen; Jokinen, Jukka

doi:10.1111/j.1365-4632.2011.05397.x

Cited by 39 publications

(54 citation statements)

References 22 publications

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“…According to recent studies [123,124,125], there is scientific basis for the traditional use of conifer resins for treatment of wounds and ulcers. Aleppo pine (needles, twigs, and buds) possesses antibacterial activity against different bacterial pathogens [125].…”

Section: Discussionmentioning

confidence: 99%

Treatment of Organic Livestock with Medicinal Plants: A Systematic Review of European Ethnoveterinary Research

et al. 2014

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Background: The EC Regulation for Organic Farming states that organic livestock should be treated preferably with phytotherapeutic products. In spite of the high importance of organic livestock in Europe, primarily ruminants, today almost no phytotherapeutic product is registered for livestock. Also, information regarding veterinary phytotherapy is rare. The aim of this paper is to find approaches to cope with health problems of organic ruminants in Europe on the basis of findings from the European ethnoveterinary medicine (EuEVM). Methods: A systematic review of ethno-biomedicinal papers was conducted with the aid of the Scopus database, and 75 papers, from European countries were analyzed regarding ethnoveterinary information. Results: A total of 590 plant species referring to 102 different plant families are reported to be used for animal treatment, with Asteraceae, Fabaceae and Lamiaceae being the most important families. The traditional use of some plant species (e.g. mallow, chamomile, wormwood) corresponds with findings from recent scientific literature. The large number of less studied plant species, such as white lupin as an antiparasitic herb, and Helleborus spp. as potential immunostimulatory agent, opens an interesting field for future research. Conclusions: In general, EuEVM provides interesting treatment approaches for gastrointestinal and dermatological disorders as well as parasitosis. Findings regarding disorders of female genital or respiratory tract are less consistent. Nevertheless, EuEVM offers a solid basis for stimulating research in veterinary phytotherapy in Europe with a perspective to solve animal health problems in organic or even nonorganic ruminant production.

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Section: Discussionmentioning

confidence: 99%

Treatment of Organic Livestock with Medicinal Plants: A Systematic Review of European Ethnoveterinary Research

et al. 2014

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“…2,[8][9][10][11][12][13][14][15][16][17] As a result of this comprehensive translational research program, we have succeeded in showing through basic, clinical, and applied research that resin treatment in wound care is feasible and clinically effective. As far as we know, our research work regarding the medical use of spruce resin and its clinical applications in modern medicine are pioneering and globally unique.…”

Section: Translational Relevancementioning

confidence: 99%

“…[10][11][12][13][14][15][16][17] Resin is a strong inhibitor of interleukin 1-beta, matrix metalloproteinase-3, and tumor necrosis factor alpha in the inflammation process, and the anti-inflammatory potential of components of resin is even superior to that of 0.5 lM dexamethasone (MD Biosciences, Inc., Glasgow, UK). Resin salve is a promising treatment option in infected or noninfected, acute or chronic, surgical or nonsurgical wounds and pressure ulcers.…”

Section: Clinical Relevancementioning

confidence: 99%

Refined Spruce Resin to Treat Chronic Wounds: Rebirth of an Old Folkloristic Therapy

Jokinen

Sipponen

2016

Advances in Wound Care

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Significance: The treatment of chronic wounds results in an enormous drain on healthcare resources in terms of workload, costs, frustration, and impaired quality of life, and it presents a clinical challenge for physicians worldwide. Effective local treatment of a chronic wound has an important role, particularly in patients who are-because of their poor general condition, diminished life expectancy, or unacceptable operative risk-outside of surgical treatment. Recent Advances: Since 2002, our multidisciplinary research group has investigated the properties of Norway spruce (Picea abies) resin in wound healing and its therapeutic applications in wound care. Resin is a complex mixture of resin acids (e.g., abietic, neoabietic, dehydroabietic, pimaric, isopimaric, levopimaric, sandrakopimaric, and palustric acids) and lignans (e.g., pino-, larici-, matairesinol, and p-hydroxycinnamic acid) having substantial antimicrobial, wound-healing, and skin regeneration enhancing properties. Critical Issues: The cornerstone in successful wound care is an efficient causal treatment of the underlying co-morbidities, for example, diabetes, malnutrition, vascular-or certain systemic diseases. However, definitive diagnosis and specific therapy of a chronic wound is often difficult, because the etiology is practically always multi-factorial, and in the chronic phase, confounding factors such as infections invariably impede wound healing. Future Directions: To study the exact molecular mechanism of actions by which resin promotes cellular regeneration and epithelialization during the wound-healing process. To investigate potential antimicrobial properties of resin against the most ominous multidrug-resistant beta-lactamase (including carbapenemases and metallo-b-lactamases) producing bacteria, and to individualize those pharmacologically active compounds which are responsible for the antimicrobial activity of resin. SCOPE AND SIGNIFICANCEAlthough at least 170 topical wound care products are available, 1,2 well-designed randomized and controlled clinical trials regarding wound care products are rare, and the number of case-control or observational studies is limited. [3][4][5] It is estimated that the care of chronic wounds in the United States costs 6-15 billion U.S. dollars annually. 6 The annual wound care costs in Denmark, a country with similar demographics to that of Finland, are estimated to be around 100 million euros.7 From the perspective of patients, community, and health-care resources, a new, safe, clinically-and cost-effective method for the treatment of chronic wounds would be undoubtedly welcome. TRANSLATIONAL RELEVANCEOur multidisciplinary research group in Finland has investigated the properties of Norway spruce (Picea abies) resin in the treatment of acute-and chronic-, either infected or noninfected, wounds for more than 10 years now. 2,[8][9][10][11][12][13][14][15][16][17] As a result of this comprehensive translational research program, we have succeeded in showing through basic, clinical, and applied research...

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“…Despite different formulation, both are antiseptics, and the microbicidal mechanisms of agents, solution and salve, are likely similar in that they both are thought to work via unspecific destruction of the microbial cell wall and cell membrane [6][7][8][9]. They may also enhance skin regrowth and regeneration [4,5].…”

Section: Introductionmentioning

confidence: 99%

“…Abilar ® 10% Resin Salve is a newer topical antiseptic ulcer agent in formulation of salve, and shows effectiveness in treatment of pressure wounds and complicated surgical wounds [4,5]. Despite different formulation, both are antiseptics, and the microbicidal mechanisms of agents, solution and salve, are likely similar in that they both are thought to work via unspecific destruction of the microbial cell wall and cell membrane [6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Healing of Neuropathic Diabetic Foot Ulcers of PEDIS Grade 1-2 at Home Care with Topical Antiseptics: An Observational Follow-Up Investigation

Korzon-Burakowska¹,

Przeździak²,

Orłowska-Kunikowska³

et al. 2017

J Clin Exp Dermatol Res

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Objective: This observational and clinical prospective follow-up study examined the healing of ordinary diabetic foot ulcers at home-care setting with two commercially available topical antiseptics, one in formulation as a solution and the other one as a salve. Method:The study population consisted of 35 consecutive adult outpatients with diabetic foot ulcers that were classified as grades 1-2 by using the PEDIS (Perfusion, Extent, Depth, Infection and Sensation) classification system. The patients were treated by two commercial antiseptics (Abilar ® 10% Resin Salve or Octenidine ® solution) and followed-up by a specialized clinic with four follow-up visits during a treatment period of 145 days on average. All patients performed the wound care at home after instructions from the clinic.Results: At study entry, the mean ulcer area was 221 mm 2 (median 140 mm 2 , interquartile range: 73-320 mm 2 ) in the salve group and 277 mm 2 (median 132 mm 2 , interquartile range: 50-365 mm 2 ) in the solution group. In intentto-treat (ITT) analysis of the whole study population of 35 patients, the ulcers healed totally in 14 (37%; 95% CI 24-56%), and in 9 of 19 patients (47%; 95% CI: 25%-77%) and in 5 of 16 patients (31%; 95% CI: 9%-54%) in the resin salve and Octenidine solution groups, respectively (P>0.05). The infected ulcer with small median size showed an insignificant trend to heal better than the other ulcers. The number of positive bacterial cultures from ulcers (bacteria of Staphylococcus and Streptococcus species in great majority of cases), taken on clinical grounds if infection was suspected, was lower in follow-up visits than at study entry. No side effects were observed. Conclusion:Treatment of diabetic foot ulcers of PEDIS grade 1-2 at home-care with topical antiseptics is an option that results in complete healing of ulcer in more than one third of cases in a 145-day treatment period.

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Natural coniferous resin salve used to treat complicated surgical wounds: pilot clinical trial on healing and costs

Cited by 39 publications

References 22 publications

Treatment of Organic Livestock with Medicinal Plants: A Systematic Review of European Ethnoveterinary Research

Treatment of Organic Livestock with Medicinal Plants: A Systematic Review of European Ethnoveterinary Research

Refined Spruce Resin to Treat Chronic Wounds: Rebirth of an Old Folkloristic Therapy

Healing of Neuropathic Diabetic Foot Ulcers of PEDIS Grade 1-2 at Home Care with Topical Antiseptics: An Observational Follow-Up Investigation

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