Natural compounds protect the skin from airborne particulate matter by attenuating oxidative stress

Diao, Ping; He, Hailun; Tang, Jie; Li, Li

doi:10.1016/j.biopha.2021.111534

Cited by 32 publications

(33 citation statements)

References 137 publications

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“…Airborne PM exposure has become a noticeable risk factor related to many cutaneous disorders in the short-or long-term such as skin allergies, acne, urticaria, eczema, contact dermatitis, dermographism, seborrhea, infected skin disease, psoriasis, dyspigmentation, skin cancer and aging [20]. Dijkhoff et al elucidated different underlying mechanisms of fine particles impacting skin through exogenous ROS induction.…”

Section: Discussionmentioning

confidence: 99%

Liposomes Encapsulating Morin: Investigation of Physicochemical Properties, Dermal Absorption Improvement and Anti-Aging Activity in PM-Induced Keratinocytes

Tran

Yang

et al. 2022

Antioxidants

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Recently, a global market for anti-aging skin care using botanicals has been noticeably developing. Morin, 3,5,7,2′,4′-pentahydroxyflavone, is a polyphenol with many pharmacological properties including antioxidant, anti-inflammation and photoprotection. However, poor aqueous solubility of morin restricts its application in pharmaceuticals. The present study aimed to encapsulate morin into liposomal vesicles to improve its water solubility and skin penetration, and further investigated its ROS inhibition and anti-aging activity in HaCaT keratinocytes induced by particulate matters (PMs). Our data presented that morin was a strong DPPH• radical scavenger. Morin displayed a remarkable ROS inhibitory ability and protected keratinocytes against PMs by downregulating matrix metalloproteinase-1 (MMP-1) expression via suppressing p-ERK and p-p38 in the MAPK pathway. Moreover, water solubility of liposomal morin (LM) prepared by the thin film hydration method was significantly better than free form of morin due to particle size reduction of LM. Our results also demonstrated that deformable liposomal vesicles were achieved for increasing dermal absorption. Additionally, LM (morin:lecinolws-50:tween-80:PF-68, 1:2.5:2.5:5) was able to effectively reduce generation of ROS, inactivate p-ERK, p-p38 and MMP-1 in HaCaT cells exposed to PM. In conclusion, our findings suggested that LM would be a bright candidate for various topical anti-aging and anti-pollution products.

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Section: Discussionmentioning

confidence: 99%

Liposomes Encapsulating Morin: Investigation of Physicochemical Properties, Dermal Absorption Improvement and Anti-Aging Activity in PM-Induced Keratinocytes

Tran

Yang

et al. 2022

Antioxidants

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“…An increased expression of TLRs by PM 2.5 , including transition metals and organic compounds, promotes the activation of extracellular signal-regulated kinase (ERK), JNK, p38 mitogen-activated protein kinase (MAPK) signals, and the NF-ҡB pathway, which reduces the phosphorylation of protein kinase B (Akt). Through this process, the ratio of BAX/BCl-2 and the expressions of caspase cascade, which induces apoptosis, increases [ 56 ]. In addition, the stimulated protein expression of the NF-ҡB pathway inhibited the expression of antioxidant enzymes, such as catalase, SOD, and heme oxygenase-1 (HO-1), by upregulating COX-2 expression [ 53 ].…”

Section: Discussionmentioning

confidence: 99%

Powdered Green Tea (Matcha) Attenuates the Cognitive Dysfunction via the Regulation of Systemic Inflammation in Chronic PM2.5-Exposed BALB/c Mice

et al. 2021

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This study was conducted to evaluate the anti-amnesic effect of the aqueous extract of powdered green tea (matcha) (EM) in particulate matter (PM)2.5-induced systemic inflammation in BALB/c mice. EM ameliorated spatial learning and memory function, short-term memory function, and long-term learning and memory function in PM2.5-induced mice. EM protected against antioxidant deficit in pulmonary, dermal, and cerebral tissues. In addition, EM improved the cholinergic system through the regulation of acetylcholine (ACh) levels and acetylcholinesterase (AChE) activity in brain tissue, and it protected mitochondrial dysfunction by regulating the production of reactive oxygen species (ROS), mitochondrial membrane potential (MMP) and ATP contents in brain tissue. EM attenuated systemic inflammation and apoptotic signaling in pulmonary, dermal, olfactory bulb, and hippocampal tissues. Moreover, EM suppressed neuronal cytotoxicity and cholinergic dysfunction in hippocampal tissue. This study suggests that EM might be a potential substance to improve PM2.5-induced cognitive dysfunction via the regulation of systemic inflammation.

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“…In addition, it was reported that 3-IPMA has free radical scavenging activity [16]. Various metabolites and natural compounds, such as monomers, phenolic compounds, and flavonoids, reduce cellular oxidative stress and the inflammatory response of PM2.5 in various cell types, including keratinocytes and fibroblasts [30][31][32]. The activation of the aryl hydrocarbon receptor (AhR) by environmental pollutants increases MMP-1 and MMP-3 expression in fibroblasts and hyperpigmentation in keratinocytes [33,34].…”

Section: Discussionmentioning

confidence: 99%

Primary Ciliogenesis by 2-Isopropylmalic Acid Prevents PM2.5-Induced Inflammatory Response and MMP-1 Activation in Human Dermal Fibroblasts and a 3-D-Skin Model

Bae

Min

Choi

et al. 2021

IJMS

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Particulate matters (PMs) increase oxidative stress and inflammatory response in different tissues. PMs disrupt the formation of primary cilia in various skin cells, including keratinocytes and melanocytes. In this study, we found that 2-isopropylmalic acid (2-IPMA) promoted primary ciliogenesis and restored the PM2.5-induced dysgenesis of primary cilia in dermal fibroblasts. Moreover, 2-IPMA inhibited the generation of excessive reactive oxygen species and the activation of stress kinase in PM2.5-treated dermal fibroblasts. Further, 2-IPMA inhibited the production of pro-inflammatory cytokines, including IL-6 and TNF-α, which were upregulated by PM2.5. However, the inhibition of primary ciliogenesis by IFT88 depletion reversed the downregulated cytokines by 2-IPMA. Moreover, we found that PM2.5 treatment increased the MMP-1 expression in dermal fibroblasts and a human 3-D-skin model. The reduced MMP-1 expression by 2-IPMA was further reversed by IFT88 depletion in PM2.5-treated dermal fibroblasts. These findings suggest that 2-IPMA ameliorates PM2.5-induced inflammation by promoting primary ciliogenesis in dermal fibroblasts.

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Natural compounds protect the skin from airborne particulate matter by attenuating oxidative stress

Cited by 32 publications

References 137 publications

Liposomes Encapsulating Morin: Investigation of Physicochemical Properties, Dermal Absorption Improvement and Anti-Aging Activity in PM-Induced Keratinocytes

Liposomes Encapsulating Morin: Investigation of Physicochemical Properties, Dermal Absorption Improvement and Anti-Aging Activity in PM-Induced Keratinocytes

Powdered Green Tea (Matcha) Attenuates the Cognitive Dysfunction via the Regulation of Systemic Inflammation in Chronic PM2.5-Exposed BALB/c Mice

Primary Ciliogenesis by 2-Isopropylmalic Acid Prevents PM2.5-Induced Inflammatory Response and MMP-1 Activation in Human Dermal Fibroblasts and a 3-D-Skin Model

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