Natural compounds protect against the pathogenesis of osteoarthritis by mediating the NRF2/ARE signaling

Wu, Zhenyu; Yang, Zhouxin; Liu, Luying; Xiao, Yihong

doi:10.3389/fphar.2023.1188215

Cited by 8 publications

(4 citation statements)

References 157 publications

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“…One work demonstrated bottom-up primary degeneration from subchondral bone during cartilage erosion in OA with aging ( Wang H. et al, 2024 ). The special relationship between subchondral bone and cartilage via various molecular signaling has been widely reported ( Wu Z. et al, 2023 ; Ouyang et al, 2023 ). For example, the subchondral bone builds a bridge between cartilage and bone to provide both mechanical and nutritional support for cartilage and maintain the stability of the cartilage microenvironment, which is the bony layer below the hyaline cartilage and cement line ( Luo et al, 2024 ).…”

Section: Bone Tissue Structure and Bone Tissue Microenvironmentmentioning

confidence: 99%

Smart responsive in situ hydrogel systems applied in bone tissue engineering

Wu,

Gai,

Chen

et al. 2024

Front. Bioeng. Biotechnol.

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The repair of irregular bone tissue suffers severe clinical problems due to the scarcity of an appropriate therapeutic carrier that can match dynamic and complex bone damage. Fortunately, stimuli-responsive in situ hydrogel systems that are triggered by a special microenvironment could be an ideal method of regenerating bone tissue because of the injectability, in situ gelatin, and spatiotemporally tunable drug release. Herein, we introduce the two main stimulus-response approaches, exogenous and endogenous, to forming in situ hydrogels in bone tissue engineering. First, we summarize specific and distinct responses to an extensive range of external stimuli (e.g., ultraviolet, near-infrared, ultrasound, etc.) to form in situ hydrogels created from biocompatible materials modified by various functional groups or hybrid functional nanoparticles. Furthermore, “smart” hydrogels, which respond to endogenous physiological or environmental stimuli (e.g., temperature, pH, enzyme, etc.), can achieve in situ gelation by one injection in vivo without additional intervention. Moreover, the mild chemistry response-mediated in situ hydrogel systems also offer fascinating prospects in bone tissue engineering, such as a Diels–Alder, Michael addition, thiol-Michael addition, and Schiff reactions, etc. The recent developments and challenges of various smart in situ hydrogels and their application to drug administration and bone tissue engineering are discussed in this review. It is anticipated that advanced strategies and innovative ideas of in situ hydrogels will be exploited in the clinical field and increase the quality of life for patients with bone damage.

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Section: Bone Tissue Structure and Bone Tissue Microenvironmentmentioning

confidence: 99%

Smart responsive in situ hydrogel systems applied in bone tissue engineering

Wu,

Gai,

Chen

et al. 2024

Front. Bioeng. Biotechnol.

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“…The pathological development of OA is multifactorial and affected by the activation of signaling cascades. Inflammatory responses and oxidative stress are involved in the progression of OA ( 23 ). Inflammation is an innate immune response triggered by pathogens or danger-related signals.…”

Section: Protective Effects Of Ginseng and Ginsenosides Against Oa De...mentioning

confidence: 99%

Protective effects of ginseng and ginsenosides in the development of osteoarthritis (Review)

Chen

Hu²,

Liao

2023

Exp Ther Med

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Osteoarthritis (OA) is a chronic inflammatory joint disease. Traditional chinese medicine provides a resource for drug screening for OA treatment. Ginseng and the associated bioactive compound, ginsenosides, may reduce inflammation, which is considered a risk factor for the development of OA. Specifically, ginsenosides may exhibit anti-inflammatory and anti-oxidative stress activities, and inhibit extracellular matrix degradation by suppressing the NF-κB and MAPK signaling pathways. Notably, specific ginsenosides, such as compound K and Rk1, may physically interact with IκB kinase and inhibit the associated phosphorylation. Thus, ginsenosides exhibit potential as therapeutic candidates in the management of OA. However, the low water solubility limits the clinical applications of ginsenosides. Numerous effective strategies have been explored to improve bioavailability; however, further investigations are still required. Contents1. Introduction 2. Protective effects of ginseng and ginsenosides against OA development 3. Anti-inflammatory properties of ginsenosides 4. Anti-oxidative activity of ginsenosides 5. Inhibitory activity of ginsenosides against ECM degradation 6. Pharmacokinetic properties of ginsenosides 7. Clinical perspectives 8. Conclusions

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“…Nuclear factor erythroid 2-related factor 2 (Nrf2), a transcription factor comprising seven conserved functional domains, named Neh1-Neh7 [16], is pivotal in orchestrating the adaptive cellular response to oxidative stress [17]. The activation of Nrf2 has been documented to mitigate oxidative stress by binding to antioxidant response elements (AREs) in the promoters of downstream antioxidant genes, such as heme oxygenase-1 (HO-1) [18]. As reported in the literature, Nrf2 knockout mice show an increased tendency to develop inflammation accompanied by extracellular matrix degradation [19].…”

Section: Introductionmentioning

confidence: 99%

Verapamil Attenuates the Severity of Tendinopathy by Mitigating Mitochondrial Dysfunction through the Activation of the Nrf2/HO-1 Pathway

Wang,

Dong,

et al. 2024

Biomedicines

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Tendinopathy is a prevalent condition in orthopedics patients, exerting a profound impact on tendon functionality. However, its underlying mechanism remains elusive and the efficacy of pharmacological interventions continues to be suboptimal. Verapamil is a clinically used medicine with anti-inflammation and antioxidant functions. This investigation aimed to elucidate the impact of verapamil in tendinopathy and the underlying mechanisms through which verapamil ameliorates the severity of tendinopathy. In in vitro experiments, primary tenocytes were exposed to interleukin-1 beta (IL−1β) along with verapamil at a concentration of 5 μM. In addition, an in vivo rat tendinopathy model was induced through the localized injection of collagenase into the Achilles tendons of rats, and verapamil was injected into these tendons at a concentration of 5 μM. The in vitro findings highlighted the remarkable ability of verapamil to attenuate extracellular matrix degradation and apoptosis triggered by inflammation in tenocytes stimulated by IL−1β. Furthermore, verapamil was observed to significantly suppress the inflammation-related MAPK/NFκB pathway. Subsequent investigations revealed that verapamil exerts a remediating effect on mitochondrial dysfunction, which was achieved through activation of the Nrf2/HO-1 pathway. Nevertheless, the protective effect of verapamil was nullified with the utilization of the Nrf2 inhibitor ML385. In summary, the in vivo and in vitro results indicate that the administration of verapamil profoundly mitigates the severity of tendinopathy through suppression of inflammation and activation of the Nrf2/HO-1 pathway. These findings suggest that verapamil is a promising therapeutic agent for the treatment of tendinopathy, deserving further and expanded research.

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Natural compounds protect against the pathogenesis of osteoarthritis by mediating the NRF2/ARE signaling

Cited by 8 publications

References 157 publications

Smart responsive in situ hydrogel systems applied in bone tissue engineering

Smart responsive in situ hydrogel systems applied in bone tissue engineering

Protective effects of ginseng and ginsenosides in the development of osteoarthritis (Review)

Verapamil Attenuates the Severity of Tendinopathy by Mitigating Mitochondrial Dysfunction through the Activation of the Nrf2/HO-1 Pathway

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