Natural compounds may contribute in preventing SARS-CoV-2 infection: a narrative review

Bizzoca, Maria Eleonora; Leuci, Stefania; Mignogna, Michele Davide; Muzio, Eleonora Lo; Caponio, Vito Carlo Alberto; Muzio, Lorenzo Lo

doi:10.1016/j.fshw.2022.04.005

Cited by 11 publications

(9 citation statements)

References 104 publications

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“…47,56,84,[91][92][93][94][95][96] Phytochemical extracts, medicinal plants and aromatic herbs, composed of polyphenols, terpinols, avonols and their glicosides, have revealed a broad spectrum of inhibitory potency and were suggested as potential anti-COVID agents. 80,[97][98][99][100][101][102][103] Several comprehensive reviews and updates on recent development of Mpro inhibitors have been released. 104,105 Here we briey summarize most crucial achievements in this eld.…”

Section: Main Protease Mpromentioning

confidence: 99%

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Main and papain-like proteases as prospective targets for pharmacological treatment of coronavirus SARS-CoV-2

Yevsieieva,

Lohachova,

Kyrychenko

et al. 2023

RSC Adv.

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Section: Main Protease Mpromentioning

confidence: 99%

“…Beside the synthetic small-molecule inhibitors, some natural compounds, such as flavones, have revealed the inhibitory potency against PLpro enzyme. 101,105,169…”

Section: Promising Targets For Pharmacological Action On Sars-cov-2mentioning

confidence: 99%

Main and papain-like proteases as prospective targets for pharmacological treatment of coronavirus SARS-CoV-2

Yevsieieva,

Lohachova,

Kyrychenko

et al. 2023

RSC Adv.

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“…Many ailments are treated with them, including asthma, bronchitis, rheumatism, headaches, and hypertension. Surprisingly, several researches have demonstrated that N. sativa seeds have the ability to treat SARS-CoV-2, the infection responsible for the recent COVID-19 pandemic ( 6 , 7 ).…”

Section: Introductionmentioning

confidence: 99%

Effects of two triterpenoids from Nigella sativa seeds on insulin resistance of 3T3-L1 adipocytes

et al. 2022

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Insulin resistance (IR) is a physiological abnormality that occurs when insulin fails to activate the signal transduction pathway in target organs. It was found that supplementation of Nigella sativa seeds with oral antidiabetic medicines helps improve blood glucose control by enhanced β cells activity and alleviation of IR. However, the activities and related mechanisms of phytochemicals from N. sativa seeds have not been thoroughly explored. In this study, the effects of two triterpenoids, 3-O-[β-D-xylopyranose-(1→3)-α-L-rhamnose-(1→2)-α-L-arabinose]-28-O-[α-L-rhamnose-(1→4)-β-D-glucopyranose-L-(1→6)-β-D-glucopyranose]-hederagenin (Hxrarg) and 3-O-[β-D-xylopyranose-(1→3)-α-L-rhamnose-(1→2)-α-L-arabinose]-hederagenin (Hxra), on IR were studied by 3T3-L1 adipocytes model. The results demonstrated that Hxrarg and Hxra inhibited maturation of 3T3-L1 preadipocytes, dramatically stimulated glucose uptake of IR-3T3-L1 adipocytes, promoted transcription of IRS, AKT, PI-3K, and GLUT4 mRNA. Western Blot results suggested that Hxrarg and Hxra were able to markedly up-regulate expression of p-IRS, p-AKT, PI-3K, and GLUT4 proteins. These findings could provide a basic foundation for the continued development and application of N. sativa in medicine and functional foods.

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“…In 2019, the novel coronavirus pneumonia (COVID-19) was found to be caused by a severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) [1][2][3], which is the seventh known coronavirus to infect humans [4] and can cause severe symptoms and even death, although it has been nearly three years since the outbreak, But it continues to wreak havoc across the globe. At present, most of the treatment methods are assisted by traditional Chinese medicine.…”

Section: Introductionmentioning

confidence: 99%

Exploring the anti novel coronavirus mechanism of Atractylodes Rhizoma based on network pharmacology and molecular docking

2022

FMSR

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Objective: To explore the potential mechanism of Atractylodes Rhizoma against COVID-19 by network pharmacology and molecular docking. Method Retrieval of Active Components and Targets in Atractylodes Rhizoma with TCMSP Database, Screening related targets of COVID-19 through GeneCards and UniProt databases, and querying the genes corresponding to the targets. Intersect drug prediction target and disease target, and draw Protein-Protein Interaction Network(PPI) through STRING database. Use DAVID database to analyze GO function enrichment and KEGG pathway of target. Then, the network diagram of "disease pathway target component drug" was constructed by using the software Cytoscape 3.9.1. Finally, download the protein receptor structure related to COVID-19 from the protein PDB database, and use the active component of Atractylodes Rhizoma as the ligand, and molecular docking with SARS-CoV-2 3CL, SARS-CoV-2 3CLpro and ACE2. Results we obtained 27 targets and 141 KEGG signal pathways of Atractylodes Rhizoma for COVID-19, mainly involving human cytomegalovirus infection, IL-17 signal pathway, TNF signal pathway and so on. The results of molecular docking showed that the main active compounds in Atractylodes Rhizoma, such as wogonin, NSC63551and Stigmasterol 3-O-beta-D-glucopyranoside, had good binding activity to COVID-19 related protein receptors. Conclusion Speculation the active compounds in Atractylodes Rhizoma may regulate multiple signal pathways by binding with ACE2, SARS-CoV-2 3CL and SARS-CoV-2 3CLpro to targets such as NOS2, AR, SCN5A, PPARG, IL-6, DPP4, and thus play the role of anti novel coronavirus.

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Natural compounds may contribute in preventing SARS-CoV-2 infection: a narrative review

Cited by 11 publications

References 104 publications

Main and papain-like proteases as prospective targets for pharmacological treatment of coronavirus SARS-CoV-2

Main and papain-like proteases as prospective targets for pharmacological treatment of coronavirus SARS-CoV-2

Effects of two triterpenoids from Nigella sativa seeds on insulin resistance of 3T3-L1 adipocytes

Exploring the anti novel coronavirus mechanism of Atractylodes Rhizoma based on network pharmacology and molecular docking

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