Natural Compounds from Plumbago zeylanica as Complementary and Alternative Medicine

Bloch, Khalida; Parihar, Vijay; Kellomäki, Minna; Ghosh, Sougata

doi:10.1007/978-981-16-5422-0_33

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2023

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“…Plumbagin is the major marker compound found in P. zeylanica 4 5 . There are several health benefits associated with plumbagin, including anti-inflammatory, antioxidant, antibacterial, antifungal, antimicrobial, wound healing, and anticancer activity against various types of cancer 6 7 .…”

Section: Introductionmentioning

confidence: 99%

Development and Validation of HPLC Method for Quantification of Plumbagin in Plumbago Zeylanica L. Roots

Shukla

Kushwaha

2023

Drug Res (Stuttg)

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Background An RP-HPLC (Reverse Phase-High-performance liquid chromatography) method for the quantitative estimation and validation of the plumbagin in the methanolic fraction of Plumbago zeylanica L. was developed. Method For achieving good separation, the RP-HPLC method was carried out with reverse phase C18 column, using methanol and water as mobile phase in the ratio of 65:35 (v/v), at the flow rate of 1 mL/min. The detection wavelength was set at 265 nm. Results The retention time of plumbagin was found at 7.5±0.2 min. The coefficient of determination of plumbagin was found to be (r2) 0.9985 and equation Y=23148x+4327. The LOD and LOQ were found to be 34.06 and 113 ng/mL, respectively. Conclusion The developed method was accurate, specific, precise, and reproducible. This RP-HPLC may be useful for quantitative estimation of the chemical constituents present in the plant extract as well as the quality assessment of the herbal product.

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Section: Introductionmentioning

confidence: 99%