Natural Compounds as New Cancer Treatments

Barrajón‐Catalán, Enrique

doi:10.3390/medicines6030078

Cited by 3 publications

(6 citation statements)

References 21 publications

(21 reference statements)

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“…Was obtained as a yellow solid (79 % yield). 1 H and 13 C NMR spectra of 3,4-DHPEA-EA and 3,4-DHPEA-EA (P) were in agreement with literature data [7]. 1 H and 13 C NMR spectra were recorded at 300 and 75 MHz respectively in CDCl3 using tetramethylsuilane (TMS) as internal standard on a Bruker ACP 300 MHz instrument.…”

Section: Synthesis Of 34-dhpea-ea and 34-dhpea-ea (P)supporting

confidence: 84%

“…Oleuropein is the main phenolic compounds of olive leaves and an important bioactive compound with various biological properties including anticancer [1], antidiabetic and antiatherosclerotic [2]. Moreover, several in vitro and in vivo studies indicate that oleuropein is a potent superoxide anion and other reactive oxygen species (ROS) scavenger [3].…”

Section: Introductionmentioning

confidence: 99%

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3,4-DHPEA-EA Peracetylated (3,4-DHPEA-EA(P)) Attenuates H2O2-Mediated Cytotoxicity in C2C12 Myocytes via Inactivation of p-JNK/p-c-Jun Signaling Pathway

Nardi¹,

Bardelli²,

Ciriolo³

et al. 2019

Preprint

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Oleuropein, glycosylated secoiridoid present in the olive leaves, is known as an important antioxidant phenolic compound. We studied the antioxidant effect of low dose of oleuropein aglycone (3,4-DHPEA-EA) and oleuropein aglycone peracetylated (3,4-DHPEA-EA(P)) in murine C2C12 myocytes treated with hydrogen peroxide (H2O2). Both compounds were used at a concentration of 10 μM and were able to inhibit cell death induced by H2O2 treatment, with 3,4-DHPEA-EA(P) being more. Under our experimental conditions H2O2 efficiently induced the phosphorylated-active form of JNK and of its downstream target c-Jun. We demonstrated, by Western blot analysis, that 3,4-DHPEA-EA(P) was efficient in inhibiting the phospho-active form of JNK. This data suggest that growth arrest and cell dead of C2C12 proceeds via the JNK/c-Jun pathway. Moreover, we demonstrated that 3,4-DHPEA-EA(P) affects myogenesis of C2C12 cells; because the MyoD mRNA levels and the differentiation process are restored after treatment with 3,4-DHPEA-EA(P). Overall, the results indicate that 3,4-DHPEA-EA(P) prevents ROS-mediated degenerative process by functioning as an efficient antioxidant.

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Section: Synthesis Of 34-dhpea-ea and 34-dhpea-ea (P)supporting

confidence: 84%

Section: Introductionmentioning

confidence: 99%

3,4-DHPEA-EA Peracetylated (3,4-DHPEA-EA(P)) Attenuates H2O2-Mediated Cytotoxicity in C2C12 Myocytes via Inactivation of p-JNK/p-c-Jun Signaling Pathway

Nardi¹,

Bardelli²,

Ciriolo³

et al. 2019

Preprint

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“…Natural products have always been an indispensable and important source in the development of innovative therapeutic drugs for a wide range of diseases, including cancer [ 12 , 13 , 14 , 15 ]. Ursolic acid (UA, 3β-hydroxy-12-urs-12-ene-28-oic-acid) is present in various fruits and vegetables and is a crucial part of the human diet [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

Ursolic Acid Accelerates Paclitaxel-Induced Cell Death in Esophageal Cancer Cells by Suppressing Akt/FOXM1 Signaling Cascade

Meng

Jin

Nguyen

et al. 2021

IJMS

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Ursolic acid (UA), a pentacyclic triterpenoid extracted from various plants, inhibits cell growth, metastasis, and tumorigenesis in various cancers. Chemotherapy resistance and the side effects of paclitaxel (PTX), a traditional chemotherapy reagent, have limited the curative effect of PTX in esophageal cancer. In this study, we investigate whether UA promotes the anti-tumor effect of PTX and explore the underlying mechanism of their combined effect in esophageal squamous cell carcinoma (ESCC). Combination treatment with UA and PTX inhibited cell proliferation and cell growth more effectively than either treatment alone by inducing more significant apoptosis, as indicated by increased sub-G1 phase distribution and protein levels of cleaved-PARP and cleaved caspase-9. Similar to the cell growth suppressive effect, the combination of UA and PTX significantly inhibited cell migration by targeting uPA, MMP-9, and E-cadherin in ESCC cells. In addition, combination treatment with UA and PTX significantly activated p-GSK-3β and suppressed the activation of Akt and FOXM1 in ESCC cells. Those effects were enhanced by the Akt inhibitor LY2940002 and inverted by the Akt agonist SC79. In an in vivo evaluation of a murine xenograft model of esophageal cancer, combination treatment with UA and PTX suppressed tumor growth significantly better than UA or PTX treatment alone. Thus, UA effectively potentiates the anti-tumor efficacy of PTX by targeting the Akt/FOXM1 cascade since combination treatment shows significantly more anti-tumor potential than PTX alone both in vitro and in vivo. Combination treatment with UA and PTX could be a new strategy for curing esophageal cancer patients.

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“…Patients facing cancer, in addition to various forms of treatment recommended by their doctors, use a variety of dietary supplements to help their body fight the disease. Among minerals, these will undoubtedly include zinc (2)(3)(4) and selenium (5,6) and among biologically active substances, polyphenolic compounds (including resveratrol and genistein) (7)(8)(9). Both in vitro studies on human cancer cells and in vivo studies on rodents have shown that zinc can inhibit the proliferation of certain types of tumour cells, while zinc deficiency increases cell proliferation and promotes inflammation (10,11).…”

mentioning

confidence: 99%

“…The role of zinc in the prevention of cancer is the result of antioxidant activity, which protects against DNA damage, and the complex effect of zinc on the immune system (induction of IL-1, IL-6, TNF-alpha, and monocytes, T cell differentiation; and others) (10,11). Polyphenolic compounds exert an anti-carcinogenic effect not only through the immune system, but also by influencing the cell cycle, apoptosis, angiogenesis and metastasis (7)(8)(9)13). Numerous studies have shown them to be promising agents in chemotherapy and other cancer treatments, alone (14,15) or in combination with existing chemotherapeutics (16,17).…”

mentioning

confidence: 99%

Changes in the Mineral Composition of Rat Tissues Induced by Breast Cancer and Dietary Supplementation

Skrajnowska

Tokarz

Makowska

et al. 2021

In Vivo

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Natural Compounds as New Cancer Treatments

Abstract: Cancer is still a global challenge worldwide with a high impact not only on human health, causing morbidity and mortality, but also on economics [...]

Cited by 3 publications

References 21 publications

3,4-DHPEA-EA Peracetylated (3,4-DHPEA-EA(P)) Attenuates H<sub>2</sub>O<sub>2</sub>-Mediated Cytotoxicity in C2C12 Myocytes <em>via</em> Inactivation of p-JNK/p-c-Jun Signaling Pathway

3,4-DHPEA-EA Peracetylated (3,4-DHPEA-EA(P)) Attenuates H<sub>2</sub>O<sub>2</sub>-Mediated Cytotoxicity in C2C12 Myocytes <em>via</em> Inactivation of p-JNK/p-c-Jun Signaling Pathway

Ursolic Acid Accelerates Paclitaxel-Induced Cell Death in Esophageal Cancer Cells by Suppressing Akt/FOXM1 Signaling Cascade

Changes in the Mineral Composition of Rat Tissues Induced by Breast Cancer and Dietary Supplementation

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