Natural compounds and the hypoxia-inducible factor (HIF) signalling pathway

Manolescu, Bogdan Nicolae; Oprea, Eliza; Busu, Carmina; Cercasov, Cornelia

doi:10.1016/j.biochi.2009.08.005

Cited by 39 publications

(25 citation statements)

References 103 publications

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“…HIF-1 protein levels in the cells are regulated by a balance between HIF-1 protein generation and degradation. Hypoxia can rapidly induce HIF-1 protein accumulation due to a marked decrease in HIF-1 protein degradation [29,30]. In our study, HIF-1 has weak expression in the normoxic conditions, so no obvious change was noticed in the normal environment.…”

Section: Discussionmentioning

confidence: 88%

RY10-4, a novel anti-tumor compound, exhibited its anti-angiogenesis activity by down-regulation of the HIF-1α and inhibition phosphorylation of AKT and mTOR

Liu

Yuan

Xue-nong

et al. 2012

Cancer Chemother Pharmacol

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Section: Discussionmentioning

confidence: 88%

RY10-4, a novel anti-tumor compound, exhibited its anti-angiogenesis activity by down-regulation of the HIF-1α and inhibition phosphorylation of AKT and mTOR

Liu

Yuan

Xue-nong

et al. 2012

Cancer Chemother Pharmacol

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“…Many studies have shown that knocking down the expression of HIF-1α could significantly control the tumor growth, inhibit angiogenesis and invasion (29,32,33), so we focused our study on HIF-1α. To date it has been shown that multiple signaling pathways are involved in the regulation of hypoxia-induced HIF-1α protein stabilization and expression.…”

Section: Discussionmentioning

confidence: 99%

Oligomer procyanidins (F2) isolated from grape seeds inhibits tumor angiogenesis and cell invasion by targeting HIF-1α in vitro

Zheng

Yang

Hou

et al. 2014

International Journal of Oncology

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Abstract. Overexpression of hypoxia-inducible factor-1 (HIF-1) α, a transcription factor which immortalizes tumors by inducing expression of the genes involved in cell survival, migration and angiogenesis, is closely associated with poor prognosis, increased risk of metastasis and increased mortality. Oligomer procyanidins (F2), a natural fraction from grape seeds, has been demonstrated to have antioxidant and antitumor activities, however the antitumor effect of F2 targeting HIF-1α remains unknown. The present study showed that F2 markedly decreased HIF-1α and the expression of its target genes in cancer cells through inactivating the EGFR-PI3K-AKT-mTOR and MAPK-ERK1/2 pathways. Moreover, F2 suppressed vascular endothelial growth factor (VEGF) and matrix metalloproteinases (MMP)-2 expressions, followed by the inhibition of tumor angiogenesis and cell invasion in a HIF-1α-dependent manner. Collectively, these findings indicate that the antitumor effect of F2 is, at least in part, mediated by suppressing HIF-1α-dependent pathway, and suggest that F2 may be a potentially useful agent for treatment of human cancer.

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“…HIF-1 induces the genes of glucose transporters, enzymes of anaerobic glycolysis, factors and enzymes included in both angiogenesis and metastassis Figure 12. ADM, adrenomedullin; ALDA, aldolase A; ALDC, aldolase C; AMF, autocrine motility factor; CATHD, cathepsin D; c-MET, hepatocyte growth-factor receptor 1; EG-VEGF, endocrine-glandderived VEGF; ENG, endoglin; ENO1, enolase 1; EPO, erythropoietin; ET1, endothelin-1; FN1, fibronectin 1; GLUT1, glucose transporter 1; GLUT3, glucose transporter 3; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; HK1, hexokinase 1; HK2, hexokinase 2; IGF-2, insulin-like growth-factor 2; KRT14, keratin 14; KRT18, keratin 18; KRT19, keratin 19; LDHA, lactate dehydrogenase A; LEP, leptin; MMP2, matrix metalloproteinase 2; NOS2, nitric oxide synthase 2; TGFA, transforming growth-factor a; PFKL, phosphofructokinase L; PFKFB3, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3; PKM, pyruvate kinase M; PGK1, phosphoglycerate kinase 1; TGF-b3, transforming growth-factor b3; TPI, triosephosphate isomerase; UPAR, urokinase plasminogen activator receptor; VEGFR2, VEGF receptor 2; VIM, vimentin [39].…”

Section: Genes Induced By Hif-1 In Cancer Cellsmentioning

confidence: 99%

HIF-1 is the Commander of Gateways to Cancer

Ma¹

2011

JCST

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The hypoxia-inducible factor-1 (HIF-1) is primarily involved in the sensing and adapting of cells to changes in the O2 level, which is essential for their viability. An increased activity is recognized in the majority of clinical relevant hypoxic/ischemic episodes and human cancers .HIF-1 is considered a central regulator of the adaptation response of cancer cells to hypoxia that makes it a therapeutic target in solid tumors. In this article, the biochemical pathways that are regulated by HIF-1 and the factors that regulate HIF-1 expression are briefly discussed .as targeting HIF-1, may selectively kill tumor cells that adapt to low O2 concentrations. HIF-1 is the Commander of Gateways to CancerNagy MA* Department of Chemistry, College of Science, Beni-Suef University, Beni-Suef, Egypt

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Natural compounds and the hypoxia-inducible factor (HIF) signalling pathway

Cited by 39 publications

References 103 publications

RY10-4, a novel anti-tumor compound, exhibited its anti-angiogenesis activity by down-regulation of the HIF-1α and inhibition phosphorylation of AKT and mTOR

RY10-4, a novel anti-tumor compound, exhibited its anti-angiogenesis activity by down-regulation of the HIF-1α and inhibition phosphorylation of AKT and mTOR

Oligomer procyanidins (F2) isolated from grape seeds inhibits tumor angiogenesis and cell invasion by targeting HIF-1α in vitro

HIF-1 is the Commander of Gateways to Cancer

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