Natural Compounds A Weapon to Ameliorate Breast Cancer Cells: A Review

Thakur, Ruchi Singh; Ahirwar, Bharti

doi:10.2174/1871520616666160826150659

Cited by 7 publications

(3 citation statements)

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“…In recent years, many naturally occurring compounds commonly present in the diet have gained considerable attention as antitumor agents [13,14]. In this regard, Resveratrol (3,5,4′-trihydroxy-stilbene) (RSV), a phytoalexin found in grapes, has been shown to exert preventive and antiproliferative effects against various types of cancer [15,16,17].…”

Section: Introductionmentioning

confidence: 99%

Steroid Receptor Signallings as Targets for Resveratrol Actions in Breast and Prostate Cancer

Amicis

Chimento

Montalto

et al. 2019

IJMS

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Extensive research over the past 25 years in hormone-dependent cancers, such as breast cancer and prostate cancer, has identified the molecular mechanisms driven by steroid receptors, elucidating the interplay between genomic and non-genomic steroid receptors mechanism of action. Altogether, these mechanisms create the specific gene expression programs that contribute to endocrine therapy resistance and cancer progression. These findings, on the bidirectional molecular crosstalk between steroid and growth factor receptors pathways in endocrine resistance, suggest the use of multi-target inhibitors together with endocrine therapies, for treating resistant disease. In this review we will discuss the novel understanding on the chemopreventive and anti-cancer activities of Resveratrol (3,5,4′-trihydroxy-stilbene) (RSV), a phytoalexin found in grapes acting on a plethora of targets. We will highlight Resveratrol effect on steroid receptors signalling and its potential use in the treatment of hormone-dependent cancer. Understanding the molecular mechanisms by which the bioactive compound influences cancer cell behaviour, by interfering with steroid receptors functional activity, will help to advance the design of combination strategies to increase the rate of complete and durable clinical response in patients.

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Section: Introductionmentioning

confidence: 99%

Steroid Receptor Signallings as Targets for Resveratrol Actions in Breast and Prostate Cancer

Amicis

Chimento

Montalto

et al. 2019

IJMS

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“…Several agents with the chemopreventive or chemotherapeutic activity have been isolated from natural products for the treatment of various diseases, including cancer. 40 Accumulating evidence has demonstrated that some of the secondary metabolites from Streptomyces sp. not only act as the antibiotics, but also exhibit anti-tumor, anti-inflammatory, and anti-drug-resistant activity in vivo.…”

Section: Discussionmentioning

confidence: 99%

A macrolide from Streptomyces sp. modulates apoptosis and autophagy through Mcl‐1 downregulation in human breast cancer cells

Chiu

et al. 2021

Environmental Toxicology

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Secondary metabolites in marine organisms exhibit various pharmacological activities against diseases, such as cancer. In this study, the anti‐proliferative effect of JBIR‐100, a macrolide isolated from Streptomyces sp., was investigated in breast cancer cells. Cell growth was inhibited in response to JBIR‐100 treatment concentration‐ and time‐dependently in both MCF‐7 and MDA‐MB‐231 breast cancer cells. JBIR‐100 caused apoptosis, as verified by caspase activation and the cleavage of PARP. Western blotting revealed that JBIR‐100 modulated the expression of Akt/NF‐κB signaling components and Bcl‐2 family members. Overexpression of Mcl‐1 partially rescued MCF‐7 cells from JBIR‐100‐induced cytotoxicity. In addition, transmission electron microscopy analyses, confocal analysis, and western blot assay indicated that JBIR‐100 inhibited autophagy in MCF‐7 cells. Exposure to the autophagy inhibitor did not synergize JBIR‐100‐induced apoptosis. In summary, our results suggested that JBIR‐100 may be potentially used for breast cancer therapy.

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“…Breast cancer patients seek for alternative therapies, mostly herbal remedies, as supportive care during cancer treatment, although the evidence of effectiveness is very limited (Greenlee et al 2017). Moreover, phytochemicals are frequently examined for search of new bioactive molecules as well as potential adjuvants in conventional anticancer therapies with numerous examples in the recent literature in our Journal and elsewhere (Newman & Cragg, ; Thakur & Ahirwar, ; Tariq et al, ; Liao, Apaya, & Shyur, ; Bae et al, ; Lin, Gong, Song, & Cui, ; Pagano, Romano, Izzo, & Borrelli, ; Marian, ; Lukong, Ogunbolude, & Kamdem, Salehi et al, ; Erices, Torres, Niechi, Bernales, & Quezada, ; Hsiao, Lin, Wang, Hsin, & Yang, ).…”

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confidence: 99%