Natural Colonization with <i>Helicobacter</i> species and the Development of Inflammatory Bowel Disease in Interleukin‐10‐deficient Mice

Zhang, Li; Danon, Stephen J.; Grehan, Martin; Chan, Vivian; Lee, Adrian V.; Mitchell, Hazel M.

doi:10.1111/j.1523-5378.2005.00314.x

Cited by 33 publications

(31 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Lesions in immunocompetent mice consist of mild to moderate lymphoplasmacytic typhlocolitis with occasional lymphoid follicle formation. As lesions progress, mild mucosal hyperplasia also occurs Whary et al 1998), as does intestinal disease in SCID, nude, and RAG1/2 knockout mice (Li et al 1998;Ward et al 1996) and in mice with a variety of targeted mutations of immune system genes, most notably the gene for the immunoregulatory cytokine IL-10 (Burich et al 2001;Erdman et al 2001;Foltz et al 1998;Zhang et al 2005). Intestinal disease in immunocompromised mice can result in rectal prolapse due to severe proliferative typhlocolitis and proctitis.…”

Section: Discoverymentioning

confidence: 95%

“…Most disease studies have focused on H. hepaticus, but several of these other species-including H. bilis Haines et al 1998;Shomer et al 1997), H. rodentium (Maurer et al 2005;Shomer et al 1998;Whary et al 2006), H. trogontum (Moura et al 2003;Whary et al 2006), H. ganmani (Zhang et al 2005), and H. cholecystus -have been associated with a range of lesions that encompass chronic to proliferative typhlocolitis, chronic active hepatitis, and cholangiohepatitis.…”

Section: Discovery Of Other Rodent Helicobacter Speciesmentioning

confidence: 97%

See 1 more Smart Citation

Lurking in the Shadows: Emerging Rodent Infectious Diseases

Besselsen¹,

Franklin²,

Livingston³

et al. 2008

ILAR Journal

View full text Add to dashboard Cite

Rodent parvoviruses, Helicobacter spp., murine norovirus, and several other previously unknown infectious agents have emerged in laboratory rodents relatively recently. These agents have been discovered serendipitously or through active investigation of atypical serology results, cell culture contamination, unexpected histopathology, or previously unrecognized clinical disease syndromes. The potential research impact of these agents is not fully known. Infected rodents have demonstrated immunomodulation, tumor suppression, clinical disease (particularly in immunodeficient rodents), and histopathology. Perturbations of organismal and cellular physiology also likely occur. These agents posed unique challenges to laboratory animal resource programs once discovered; it was necessary to develop specific diagnostic assays and an understanding of their epidemiology and transmission routes before attempting eradication, and then evaluate eradication methods for efficacy. Even then management approaches varied significantly, from apathy to total exclusion, and such inconsistency has hindered the sharing and transfer of rodents among institutions, particularly for genetically modified rodent models that may not be readily available. As additional infectious agents are discovered in laboratory rodents in coming years, much of what researchers have learned from experiences with the recently identified pathogens will be applicable. This article provides an overview of the discovery, detection, and research impact of infectious agents recently identified in laboratory rodents. We also discuss emerging syndromes for which there is a suspected infectious etiology, and the unique challenges of managing newly emerging infectious agents.

show abstract

Section: Discoverymentioning

confidence: 95%

Section: Discovery Of Other Rodent Helicobacter Speciesmentioning

confidence: 97%

Lurking in the Shadows: Emerging Rodent Infectious Diseases

Besselsen¹,

Franklin²,

Livingston³

et al. 2008

ILAR Journal

View full text Add to dashboard Cite

show abstract

“…Beside the direct pathological effects of EHS, it has been shown that infections of mice by EHS may significantly influence the results of animal experiments (4,5,14,41). However, investigators may not be aware that their laboratory mice are Helicobacter infected because the pathology of EHS is host dependent and infection may be subclinical (39).…”

mentioning

confidence: 99%

“…In susceptible mice, infections with H. typhlonius (12), H. ganmani (41), or H. muridarum (15) are associated with inflammatory bowel disease. Monoinfection with H. rodentium has not been shown to be associated with disease; however, the germ augments inflammatory bowel disease in immunodeficient mice coinfected with H. hepaticus (23).…”

mentioning

confidence: 99%

Prevalence and Spread of Enterohepatic Helicobacter Species in Mice Reared in a Specific-Pathogen-Free Animal Facility

et al. 2006

View full text Add to dashboard Cite

Infections with enterohepatic Helicobacter species (EHS) can change the results of animal experiments.However, there is little information about the prevalence of EHS in noncommercial animal facilities. The aim of this study was to investigate the prevalence and the spread of EHS in specific-pathogen-free (SPF) mice. Fecal samples of 40 mouse lines were analyzed for members of the family Helicobacteraceae using a group-specific PCR targeting the 16S rRNA gene. Additional experiments were carried out to evaluate the spread of EHS among mice harbored in different caging systems. Helicobacter species were detected in 87.5% of the mouse lines tested. Five different Helicobacter species were identified: H. ganmani, H. hepaticus, H. typhlonicus, and the putative Helicobacter species represented by the isolates hamster B and MIT 98-5357. Helicobacter infection did not spread between animals in neighboring cages when individually ventilated cages were used; in contrast, when the mice were reared in open-air cages, EHS were found to spread from cage to cage. However, the spread was prevented by adding polycarbonate filter tops to the cages. When Helicobacter-negative and infected mice shared the same cage, transmission of the infection occurred in 100% within 2 weeks. Furthermore, we found that mice from commercial breeding facilities may carry undetected Helicobacter infections. Taken together, we show that infection with EHS may frequently occur and spread easily in mice reared under SPF conditions despite extensive safety precautions. Moreover, there is a high prevalence of rather uncommon Helicobacter species that may be a consequence of the current routine procedures used for health screening of SPF mice.

show abstract

“…By eliminating IL-10, one would expect to reveal proinflammatory responses generated against enteric pathogens and subsequent pathological manifestations. For instance, C57BL/6 IL-10 Ϫ/Ϫ mice have proved effective in the study of GI tract disease associated with Helicobacter species (15,74). The immunological basis of Helicobacter hepaticus-associated colitis in IL-10 Ϫ/Ϫ mice (33,34), along with bacterial virulence determinants such as cytolethal distending toxin (72), has been studied extensively.…”

mentioning

confidence: 99%