“…Accordingly, a nanocarrier has been recently produced by coating the natural clinoptilolite nanoparticles’ surface with a phosphatidylcholine layer [ 108 ]. Phosphatidylcholine was tested previously, as an absorption enhancer with properties directed towards biological barrier permeation and improvement of drug diffusion [ 117 , 118 ]. Figure 5.…”
Section: Polyphenols From the Mediterranean Diet And Potential Carrie...mentioning
Objectives:
Many polyphenols such as EGCG from green tea, curcumin, apigenin, resveratrol or the alkaloid berberine show in-vitro activity that is much higher than FDA and EU approved drugs. And yet, while mice studies show excellent results, human clinical trials have so far been quite disappointing.
Methods:
In this review paper we accordingly present data from scientific literature and publicly available databases that support further development of nanoformulations for enhanced natural antioxidants bioavailability and activity.
Results:
Nanobubbles, and nanoparticles may enhance the polyphenols bioavailability and special coatings can be used to avoid liver fast inactivation. Zeolites have also been tested as carriers for bioactive compounds from the Mediterranean food. Other polyphenols can be used with nanoemulsions for synergistic antioxidants treatment. Finally, nanobubbles in the presence of ferric or copper ions at low pH as in human stomach or lysosomes can produce small amount of hydroxyl radicals, stimulating activation of Nrf2 transcription factor and detox enzymes.
Discussion:
A number of nanoformulations, including nanobubbles loaded with natural antioxidants may be used with low carbs and protein diet as a support to chemotherapy or treatment of advanced tumors. Good results in animal studies of neurodegenerative diseases and type II diabetes were also observed.
KEY POLICY HIGHLIGHTS
Nanobubbles and nanoparticles may enhance the polyphenols’ bioavailability
Nanobubbles may stimulate the activation of Nrf2 and detox enzymes
Armoured oxygen nanobubbles may enhance radiotherapy or chemotherapy effects
“…Accordingly, a nanocarrier has been recently produced by coating the natural clinoptilolite nanoparticles’ surface with a phosphatidylcholine layer [ 108 ]. Phosphatidylcholine was tested previously, as an absorption enhancer with properties directed towards biological barrier permeation and improvement of drug diffusion [ 117 , 118 ]. Figure 5.…”
Section: Polyphenols From the Mediterranean Diet And Potential Carrie...mentioning
Objectives:
Many polyphenols such as EGCG from green tea, curcumin, apigenin, resveratrol or the alkaloid berberine show in-vitro activity that is much higher than FDA and EU approved drugs. And yet, while mice studies show excellent results, human clinical trials have so far been quite disappointing.
Methods:
In this review paper we accordingly present data from scientific literature and publicly available databases that support further development of nanoformulations for enhanced natural antioxidants bioavailability and activity.
Results:
Nanobubbles, and nanoparticles may enhance the polyphenols bioavailability and special coatings can be used to avoid liver fast inactivation. Zeolites have also been tested as carriers for bioactive compounds from the Mediterranean food. Other polyphenols can be used with nanoemulsions for synergistic antioxidants treatment. Finally, nanobubbles in the presence of ferric or copper ions at low pH as in human stomach or lysosomes can produce small amount of hydroxyl radicals, stimulating activation of Nrf2 transcription factor and detox enzymes.
Discussion:
A number of nanoformulations, including nanobubbles loaded with natural antioxidants may be used with low carbs and protein diet as a support to chemotherapy or treatment of advanced tumors. Good results in animal studies of neurodegenerative diseases and type II diabetes were also observed.
KEY POLICY HIGHLIGHTS
Nanobubbles and nanoparticles may enhance the polyphenols’ bioavailability
Nanobubbles may stimulate the activation of Nrf2 and detox enzymes
Armoured oxygen nanobubbles may enhance radiotherapy or chemotherapy effects
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