Natural cardiac regeneration conserves native biaxial left ventricular biomechanics after myocardial infarction in neonatal rats

Wang, Hanjay; Wisneski, Andrew D.; Imbrie-Moore, Annabel M.; Paulsen, Michael J.; Wang, Zhongjie; Xuan, Yue; Hernandez, Hector Lopez; Hironaka, Camille E.; Lucian, Haley J.; Shin, Hye Sook; Anilkumar, Shreya; Thakore, Akshara D.; Farry, Justin M.; Eskandari, Anahita; Williams, Kiah M; Grady, Frederick; Wu, Matthew A.; Jung, Jinsuh; Stapleton, Lyndsay M.; Steele, Amanda N.; Zhu, Yuanjia; Woo, Y. Joseph

doi:10.1016/j.jmbbm.2022.105074

Cited by 3 publications

(3 citation statements)

References 51 publications

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“…This normalization of electrical conduction after P1 MI in piglets was achieved despite the presence of a small residual scar, the size of which was similar to that of a previous report ( 17 ). It is possible that, akin to how cardiac biomechanical properties may be preserved by myocardial regeneration despite the presence of a small infarct remaining after MI ( 26 , 34 , 35 ), there may also be a threshold of scar formation below which ventricular conduction dynamics are not significantly disrupted.…”

Section: Discussionmentioning

confidence: 99%

Electrophysiologic Conservation of Epicardial Conduction Dynamics After Myocardial Infarction and Natural Heart Regeneration in Newborn Piglets

Wang

Pong

Obafemi

et al. 2022

Front. Cardiovasc. Med.

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Newborn mammals, including piglets, exhibit natural heart regeneration after myocardial infarction (MI) on postnatal day 1 (P1), but this ability is lost by postnatal day 7 (P7). The electrophysiologic properties of this naturally regenerated myocardium have not been examined. We hypothesized that epicardial conduction is preserved after P1 MI in piglets. Yorkshire-Landrace piglets underwent left anterior descending coronary artery ligation at age P1 (n = 6) or P7 (n = 7), After 7 weeks, cardiac magnetic resonance imaging was performed with late gadolinium enhancement for analysis of fibrosis. Epicardial conduction mapping was performed using custom 3D-printed high-resolution mapping arrays. Age- and weight-matched healthy pigs served as controls (n = 6). At the study endpoint, left ventricular (LV) ejection fraction was similar for controls and P1 pigs (46.4 ± 3.0% vs. 40.3 ± 4.9%, p = 0.132), but significantly depressed for P7 pigs (30.2 ± 6.6%, p < 0.001 vs. control). The percentage of LV myocardial volume consisting of fibrotic scar was 1.0 ± 0.4% in controls, 9.9 ± 4.4% in P1 pigs (p = 0.002 vs. control), and 17.3 ± 4.6% in P7 pigs (p < 0.001 vs. control, p = 0.007 vs. P1). Isochrone activation maps and apex activation time were similar between controls and P1 pigs (9.4 ± 1.6 vs. 7.8 ± 0.9 ms, p = 0.649), but significantly prolonged in P7 pigs (21.3 ± 5.1 ms, p < 0.001 vs. control, p < 0.001 vs. P1). Conduction velocity was similar between controls and P1 pigs (1.0 ± 0.2 vs. 1.1 ± 0.4 mm/ms, p = 0.852), but slower in P7 pigs (0.7 ± 0.2 mm/ms, p = 0.129 vs. control, p = 0.052 vs. P1). Overall, our data suggest that epicardial conduction dynamics are conserved in the setting of natural heart regeneration in piglets after P1 MI.

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Section: Discussionmentioning

confidence: 99%

Electrophysiologic Conservation of Epicardial Conduction Dynamics After Myocardial Infarction and Natural Heart Regeneration in Newborn Piglets

Wang

Pong

Obafemi

et al. 2022

Front. Cardiovasc. Med.

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“…One study has even shown functional restoration post-injury in a neonatal human heart 31 . In addition to preserving normal cardiac structure and function, natural heart regeneration in neonatal mammals has also been demonstrated to restore healthy epicardial conduction dynamics and preserve native left ventricular tissue biomechanics [32][33][34] .…”

Section: Mammalian Response To Cardiac Injurymentioning

confidence: 99%

Structural, angiogenic, and immune responses influencing myocardial regeneration: a glimpse into the crucible

Baccouche,

Elde,

Wang

et al. 2024

npj Regen Med

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Complete cardiac regeneration remains an elusive therapeutic goal. Although much attention has been focused on cardiomyocyte proliferation, especially in neonatal mammals, recent investigations have unearthed mechanisms by which non-cardiomyocytes, such as endothelial cells, fibroblasts, macrophages, and other immune cells, play critical roles in modulating the regenerative capacity of the injured heart. The degree to which each of these cell types influence cardiac regeneration, however, remains incompletely understood. This review highlights the roles of these non-cardiomyocytes and their respective contributions to cardiac regeneration, with emphasis on natural heart regeneration after cardiac injury during the neonatal period.

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“…To date, a single study provides in vivo evidence of the functional impact of mechanical forces during neonatal heart regeneration. Wang et al (2022) [ 274 ] demonstrated that the natural biaxial ventricular mechanics are conserved after neonatal heart regeneration, a characteristic that is missing in adult myocardial infarcted hearts.…”

Section: The Role Of Mechanical Stress In Cardiac Regenerationmentioning

confidence: 99%

Comparative Analysis of Heart Regeneration: Searching for the Key to Heal the Heart—Part II: Molecular Mechanisms of Cardiac Regeneration

Castillo-Casas,

Caño-Carrillo,

Sánchez-Fernández

et al. 2023

JCDD

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Cardiovascular diseases are the leading cause of death worldwide, among which ischemic heart disease is the most representative. Myocardial infarction results from occlusion of a coronary artery, which leads to an insufficient blood supply to the myocardium. As it is well known, the massive loss of cardiomyocytes cannot be solved due the limited regenerative ability of the adult mammalian hearts. In contrast, some lower vertebrate species can regenerate the heart after an injury; their study has disclosed some of the involved cell types, molecular mechanisms and signaling pathways during the regenerative process. In this ‘two parts’ review, we discuss the current state-of-the-art of the main response to achieve heart regeneration, where several processes are involved and essential for cardiac regeneration.

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Natural cardiac regeneration conserves native biaxial left ventricular biomechanics after myocardial infarction in neonatal rats

Cited by 3 publications

References 51 publications

Electrophysiologic Conservation of Epicardial Conduction Dynamics After Myocardial Infarction and Natural Heart Regeneration in Newborn Piglets

Electrophysiologic Conservation of Epicardial Conduction Dynamics After Myocardial Infarction and Natural Heart Regeneration in Newborn Piglets

Structural, angiogenic, and immune responses influencing myocardial regeneration: a glimpse into the crucible

Comparative Analysis of Heart Regeneration: Searching for the Key to Heal the Heart—Part II: Molecular Mechanisms of Cardiac Regeneration

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