Natural biopolyester microspheres with diverse structures and surface topologies as micro-devices for biomedical applications

Wang, Zeyu; Zhang, Xu-Wei; Ding, Yanwen; Ren, Zi-Wei; Wei, Daixu

doi:10.1016/j.smaim.2022.07.004

Cited by 20 publications

(10 citation statements)

References 224 publications

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“…It was found that upon contacting the ECM substrate, the diffusion and spreading of stem cell loaded microspheres were similar to that of droplets touching the substrate ( Chatzinikolaidou, 2016 ; Dhamecha et al, 2019 ). Compared to conventional cell culture methodology, the microspheres have a higher specific surface area, and the multi-microsphere assembly scaffold has an interconnected porous structure, which provides more space for cells to proliferate and differentiate, thereby accurately simulating the natural tissue microenvironment ( He et al, 2020 ; Wang et al, 2023 ). In our study, by fabricating the BMSC-coated hydrogel microsphere, the biomaterial incorporated with the cell phospholipid bilayer attains superwetting property that facilitates tissue spreading at the ultrastructural level.…”

Section: Resultsmentioning

confidence: 99%

Superwettable and injectable GelMA-MSC microspheres promote cartilage repair in temporomandibular joints

Yang

Huang²,

Zheng³

et al. 2022

Front. Bioeng. Biotechnol.

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Temporomandibular disorders (TMD) can be treated by promoting cartilage regeneration with biomaterials. However, there are deficiencies in the infiltration function of bone filler biological materials. In this study, stems cells were loaded onto gelatin methacryloyl (GelMA) hydrogel microspheres endowed with superwettable properties and TGF-β sustained-release function, which can quickly infiltrate the irregular surface of the temporomandibular joint (TMJ) bone defect area and accelerate cartilage healing. First, to improve cell adhesion and spreading function, the BMSCs-coated GelMA microspheres were endowed with superwetting property. At the same time, the swelling adsorption characteristics of gelatin microspheres could be used to load recombinant TGF-β within the microspheres, which could in turn promote the chondrogenic differentiation of multi-potent bone marrow mesenchymal stem cells. The SEM imaging demonstrated that BMSCs-coated GelMA microsphere has superwettable and superhydrophilic property, which enabled rapid adaptation to the bone defect surface morphology, which is conducive to tissue repair. Furthermore, the cartilage defect model showed that rBMSCs-coated GelMA microspheres promote temporomandibular joint arthritis repair. In conclusion, our study established that BMSC-coated GelMA microspheres endowed with superwetting properties, can colonize the bone defect repair site better with sustained release of growth factors, thus providing an innovative strategy for promoting cartilage regeneration.

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Section: Resultsmentioning

confidence: 99%

Superwettable and injectable GelMA-MSC microspheres promote cartilage repair in temporomandibular joints

Yang

Huang²,

Zheng³

et al. 2022

Front. Bioeng. Biotechnol.

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“…Due to the hydrophilic properties of this highly negatively charged polysaccharide, HA can imbibe water to achieve considerable mechanical robustness. As an essential component of the endogenous or synthetic ECM, HA has been proven to be effective at inducing cellular proliferation [ 25 , 26 ]. In contrast to animal tissue, which has potential pathogenicity and limited sources, HA is easily synthesized on a large scale using various engineered bacteria such as Lactococcus lactis [ 27 ], Pichia pastoris [ 28 ] and Streptococcus [ 29 ], which avoided the residue of pathogens in animals.…”

Section: Biosynthesis and Engineering Of Natural Biomaterialsmentioning

confidence: 99%

“…Considering that the applications of BNBMs are diversified and often susceptible to mechanical disruption, the requirements for BNBMs in tissue-specific performance and challenges in various harsh physiological conditions have also increased. Inspired by the self-healing properties of human tissue after minor damage, self-healing BNBMs were designed and developed mainly based on non-covalent interactions (such as hydrogen bonds, van der Waals forces), weak covalent bonds (for instance, acylhydrazone bond), ionic complexes and other design methods [ 25 , 41 , 56 , 179 ]. The self-healing properties endow BNBMs capable of catering to the clinical requirements and promising to replace the traditional brittle stents in the fields of orthopedics, heart, skin, and muscle repair [ 25 , 41 , 179 ].…”

Section: Rational Design and Preparation Of Bnbms Enabling With Ecm F...mentioning

confidence: 99%

Biomimetic natural biomaterials for tissue engineering and regenerative medicine: new biosynthesis methods, recent advances, and emerging applications

Liu

Gan

et al. 2023

Military Med Res

Self Cite

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Biomimetic materials have emerged as attractive and competitive alternatives for tissue engineering (TE) and regenerative medicine. In contrast to conventional biomaterials or synthetic materials, biomimetic scaffolds based on natural biomaterial can offer cells a broad spectrum of biochemical and biophysical cues that mimic the in vivo extracellular matrix (ECM). Additionally, such materials have mechanical adaptability, microstructure interconnectivity, and inherent bioactivity, making them ideal for the design of living implants for specific applications in TE and regenerative medicine. This paper provides an overview for recent progress of biomimetic natural biomaterials (BNBMs), including advances in their preparation, functionality, potential applications and future challenges. We highlight recent advances in the fabrication of BNBMs and outline general strategies for functionalizing and tailoring the BNBMs with various biological and physicochemical characteristics of native ECM. Moreover, we offer an overview of recent key advances in the functionalization and applications of versatile BNBMs for TE applications. Finally, we conclude by offering our perspective on open challenges and future developments in this rapidly-evolving field.

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“…However, the commercialization of these materials is quite harmful to the environment. 109,110 Plastics made from petroleum, which are not biodegradable, typically take decades or even hundreds of years to degrade. 111,112…”

Section: Biodegradable Polymers Applied In Food Packagingmentioning

confidence: 99%

Polymer blends of poly(lactic acid) and starch for the production of films applied in food packaging: A brief review

Silva

Rios

Santana

2023

Polymers from Renewable Resources

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The limited degradation of synthetic polymers used in food packaging when discarded in the environment is a major concern for society. Therefore, industry and academia have sought to develop biodegradable and eco-friendly materials for single-use in packaging. An interesting alternative for the food industry is biodegradable polymeric films, which is why different biopolymers have been used in the production of sustainable packaging. It is worth mentioning that the use of biodegradable polymers is one of the most successful innovations in the industry to address issues related to the environment. Among the available raw materials, starch extracted from different renewable sources is very promising for this purpose, due to its abundance, low-cost compared to other polymers and ability to produce non-toxic films. However, when used alone, pure starch has many limitations, which can be overcome by developing a mixture with other polymers (polymer blends), preferably from renewable and biodegradable sources, such as poly(lactic acid) (PLA). In this context, the absence of literature reviews evidencing the results of the application of films in foods led us to write this article, given the importance of polymer blends produced with different types of starch (cassava, corn, pea, potato, rice and wheat) and the PLA matrix. According to the results, it is clear that polymer blends based on PLA/Starch for food packaging are very promising, already being part of the industries solutions, aiming to minimize the large volume of plastic waste of petrochemical origin discarded in nature. Obviously, as with any technology, more research is needed to further improve the performance of the films, and while much research has made great strides, there are still limitations that prevent the commercialization of these materials.

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Natural biopolyester microspheres with diverse structures and surface topologies as micro-devices for biomedical applications

Cited by 20 publications

References 224 publications

Superwettable and injectable GelMA-MSC microspheres promote cartilage repair in temporomandibular joints

Superwettable and injectable GelMA-MSC microspheres promote cartilage repair in temporomandibular joints

Biomimetic natural biomaterials for tissue engineering and regenerative medicine: new biosynthesis methods, recent advances, and emerging applications

Polymer blends of poly(lactic acid) and starch for the production of films applied in food packaging: A brief review

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