Natural Antioxidants and Medicinal Plants Effective on Hyperlipidemia

Ebrahimi, Yahya; Hasanvand, Afshin; Valibeik, Ali; Ebrahimi, Farzad; Abbaszadeh, Sepideh

doi:10.5958/0974-360x.2019.00242.7

Cited by 8 publications

(6 citation statements)

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“…The C. medica has significant antioxidant properties due to the presence of an excellent antioxidant, ascorbic acid, in addition to known phenolic compounds, flavonoids, carotenoids, and heteropolysaccharides, which contribute to antioxidant capacity in citrus fruits. Several studies have evaluated the antioxidant activities of different parts of C. medica in combination with the total contents of phenols and flavonoids, widely known as molecules with marked antioxidant activity [ 36 , 94 , 95 , 96 ]. In fact, Luo et al [ 41 ] investigated the major flavonoids of finger citron, prepared by continuous phase-transition extraction (CPE), purified with AB-8 macroporous resins and then identified by UHPLC–QTOF–MS, showing good radical-scavenging activity on an in vitro test.…”

Section: Resultsmentioning

confidence: 99%

An Insight into Citrus medica Linn.: A Systematic Review on Phytochemical Profile and Biological Activities

Benedetto,

Carlucci,

Faraone

et al. 2023

Plants

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Plant species are a reservoir of natural compounds that can potentially be used to treat different diseases. Citrus medica Linn. belonging to the Rutaceae family, has been used for centuries in medicine for its antioxidant, anti-inflammatory, antimicrobial, antiviral, and antihyperglycemic properties. These activities are ascribable not only to the presence of health-promoting macronutrients and micronutrients, such as carbohydrates, minerals, amino acids, and vitamins, but also to specialized metabolites, such as flavonoids (apigenin, hesperetin, hesperidin, naringin, naringenin, rutin, quercetin, and diosmin), coumarins (citropten, scoparone, and bergapten), terpenes (limonene, γ-terpinene, limonin, and nomilin), and phenolic acids (p-coumaric acid, trans-ferulic acid, and chlorogenic acid). In recent years, particular attention has been focused on the antioxidant, anti-inflammatory, antimicrobial activity, antidiabetic, anticancer, and neuroprotective activity of C. medica. However, although many studies have reported this species’ chemical and biological properties, the literature has never been analyzed via a systematic approach. For this reason, using PubMed and Scopus as databases, we performed a systematic review of C. medica’s chemical composition and biological properties to inspire new research approaches and increase its curative application.

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Section: Resultsmentioning

confidence: 99%

An Insight into Citrus medica Linn.: A Systematic Review on Phytochemical Profile and Biological Activities

Benedetto,

Carlucci,

Faraone

et al. 2023

Plants

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“…Several polyphenols were isolated from cinnamon including rutin (90.06%), catechin (1.90%), quercetin (0.17%), kaempferol (0.02%), and isorhamnetin (0.10%) [25][26][27]. Several reports indicated that cinnamon has blood glucose and cholesterol-lowering activities [27][28][29].…”

Section: Discussionmentioning

confidence: 99%

Herbal therapy in diabetes mellitus: A review

Gholamine,

Malviya,

Rudiansyah

et al. 2024

Adv. life sci.

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Insulin therapy is the mainstay of treatment in patients with type 1 diabetes, while diet and lifestyle changes, and if left untreated, insulin therapy are effective in treating type 2 diabetes. Research has shown that the oldest treatment for diabetes was the use of herbs. Thus, various medicinal plants were used to relieve many of the complications of diabetes. This study aimed to assess the effectiveness of various medicinal plants in the treatment of diabetes. The data on medicinal plants and diabetes were collected from related articles published from 2014 to 2021 in reputable databases such as Cochrane, PubMed, Scopus, ScienceDirect, Embase, and SID. Data analysis showed that medicinal plants such as Allium sativum, Cinnamomum verum, Trigonella graecum foenum, Silybum marianus, Citrullus colocynthis, Abelmoschus esculentus, Eryngium, Coriandrum sativum L, and Zingiber officinale were the most frequently used herbs in the treatment of diabetes. Medicinal plants can reduce blood sugar in patients due to having effective medicinal compounds and natural antioxidants and due to the least side effects but longer treatment period.Keywords: Diabetes; Medicinal plants; Remedy; Pharmaceutical Plant

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“…Any deviation in the lipid profile results in several heart issues inclusive myocardial infarction, cardiovascular diseases (CVD), stroke, and atherosclerosis [108]. Medicinal plants gained attention for the treatment of lipidemia and associated ailments due to the side effects of synthetic drugs [109]. Along this line, the S. cumini seeds flavonoid-rich fraction was evaluated for antilipidemic potential; results showed a reduction in low-density lipoproteins (LDL) levels and elevation of high-density lipoproteins (HDL) levels in rats [110].…”

Section: Hyperlipidemia and Cardioprotective Activitymentioning

confidence: 99%

“…Research findings also showed cardioprotective effects of S. cumini fruit ethanol extract [112]. Cardiovascular diseases are one of the important causes of death in industrialized nations, and hyperlipidemia is one of the main causes of cardiovascular ailments [109]. In this respect, work by Nahid et al (2017) [113] revealed that methanol seed extract of S. cumini exhibits cardioprotective activity in isoproterenol-induced myocardial infarction in rats.…”

Section: Hyperlipidemia and Cardioprotective Activitymentioning

confidence: 99%

Phytochemical Profile, Biological Properties, and Food Applications of the Medicinal Plant Syzygium cumini

Qamar

Akhtar

Ismail

et al. 2022

Foods

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Syzygium cumini, locally known as Jamun in Asia, is a fruit-bearing crop belonging to the Myrtaceae family. This study aims to summarize the most recent literature related to botany, traditional applications, phytochemical ingredients, pharmacological activities, nutrition, and potential food applications of S. cumini. Traditionally, S. cumini has been utilized to combat diabetes and dysentery, and it is given to females with a history of abortions. Anatomical parts of S. cumini exhibit therapeutic potentials including antioxidant, anti-inflammatory, analgesic, antipyretic, antimalarial, anticancer, and antidiabetic activities attributed to the presence of various primary and secondary metabolites such as carbohydrates, proteins, amino acids, alkaloids, flavonoids (i.e., quercetin, myricetin, kaempferol), phenolic acids (gallic acid, caffeic acid, ellagic acid) and anthocyanins (delphinidin-3,5-O-diglucoside, petunidin-3,5-O-diglucoside, malvidin-3,5-O-diglucoside). Different fruit parts of S. cumini have been employed to enhance the nutritional and overall quality of jams, jellies, wines, and fermented products. Today, S. cumini is also used in edible films. So, we believe that S. cumini’s anatomical parts, extracts, and isolated compounds can be used in the food industry with applications in food packaging and as food additives. Future research should focus on the isolation and purification of compounds from S. cumini to treat various disorders. More importantly, clinical trials are required to develop low-cost medications with a low therapeutic index.

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Natural Antioxidants and Medicinal Plants Effective on Hyperlipidemia

Cited by 8 publications

References 0 publications

An Insight into Citrus medica Linn.: A Systematic Review on Phytochemical Profile and Biological Activities

An Insight into Citrus medica Linn.: A Systematic Review on Phytochemical Profile and Biological Activities

Herbal therapy in diabetes mellitus: A review

Phytochemical Profile, Biological Properties, and Food Applications of the Medicinal Plant Syzygium cumini

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