Natural Antimicrobial Peptides from Eukaryotic Organisms

Condé, Renaud; Argüello, Martha; Izquierdo, Javier; Noguez, Raúl; Moreno, M.; Lanz, Humberto

doi:10.5772/33293

Cited by 4 publications

(6 citation statements)

References 125 publications

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“…When the threshold concentration level of peptide reaches to maximum, these molecules penetrate into lipid membrane of bacteria. In the year 1999, according to Shai-Matsuzaki-Huang, in ''carpet'' model globular bilayer destabilization occurs which marks the membrane disruption of microorganisms (Conde et al 2012;Berglund et al 2015). …”

Section: Carpet Modelmentioning

confidence: 99%

Antimicrobial peptides as natural bio-preservative to enhance the shelf-life of food

et al. 2016

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Antimicrobial peptides (AMPs) are diverse group of natural proteins present in animals, plants, insects and bacteria. These peptides are responsible for defense of host from pathogenic organisms. Chemical, enzymatic and recombinant techniques are used for the synthesis of antimicrobial peptides. These peptides have been found to be an alternative to the chemical preservatives. Currently, nisin is the only antimicrobial peptide, which is widely utilized in the preservation of food. Antimicrobial peptides can be used alone or in combination with other antimicrobial, essential oils and polymeric nanoparticles to enhance the shelf-life of food. This review presents an overview on different types of antimicrobial peptides, purification techniques, mode of action and application in food preservation.

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Section: Carpet Modelmentioning

confidence: 99%

Antimicrobial peptides as natural bio-preservative to enhance the shelf-life of food

et al. 2016

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“…Some examples of peptides that work through the barrel stave model mechanisms are alamethicin and gramicidin S [13,44,45]. Bioinformatic analysis of protegrin 1 conformed that the calculated energy of peptide insertion in artificial membranes was most congruent with this model (Figure 4(a)) [26,33].…”

Section: Barrel-stave Modelmentioning

confidence: 84%

“…AMPs not only directly target and destroy bacteria but may exert their antimicrobial activity by immune modulatory mechanism [20]. AMPs display their immune-modulatory effects in different ways, like reducing the endotoxin-induced inflammatory response, provoking synthesis of pro-inflammatory factors and cytokines, controlling adaptive immunity, and finally recruiting macrophages to show immune modulatory effects [25][26][27]. These peptides enhance the body's ability to fight microbes rather than directly killing bacteria [4].…”

Section: Immunological Regulation Mechanism Of Actionmentioning

confidence: 99%

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Antimicrobial Peptides: Mechanism of Action

Singh,

Choudhary,

Singh

2022

Insights on Antimicrobial Peptides

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Antimicrobial peptides (AMPs) are a diverse class of small peptides that are found in most life forms ranging from microorganisms to humans. They can provoke innate immunity response and show activity against a wide range of microbial cells which includes bacteria, fungi, viruses, parasites, and even cancer cells. In recent years AMPs have gained considerable attention as a therapeutic agent since bacterial resistance towards conventional antibiotics is accelerating rapidly. Thus, it is essential to analyze the mechanism of action (MOA) of AMPs to enhance their use as therapeutics. The MOA of AMPs is classified into two broad categories: direct killing and immunological regulation. The direct killing action mechanism is categorized into membrane targeting and non-membrane targeting mechanisms. There are several models and biophysical techniques which determine the action mechanism of antimicrobial peptides.

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“…However, only two types of PTMs are found ubiquitously among the AMPs of eukaryotic organisms [6] of which the first is the oxidation of an amino acid residue (cysteine) to form disulfide bridges [14]. Scientists have observed that disulfide bridges play an important and major architectural role in the antimicrobial effect of AMPs [6], mainly by maintaining the amphipathic topography of the biologically studied molecules and thus their ability to interact with target membranes and kill Host cells [5,15]. This form of structural stabilization is critical for the therapeutic development of AMPs and furthermore is demonstrated by the cysteine knot architectures of cyclotides from plants [2,16].…”

Section: Introductionmentioning

confidence: 99%

Peptide Chemistry's Role in Treating Most Serious Diseases: Peptide Antibiotics

Moustafa

Shalaby

2021

Egypt. J. Chem.

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The study of antimicrobial peptides is a rapidly growing field. Antibacterial peptides were first considered rather speciesspecific. Therefore, we focused our review of peptide antibiotics, although the peptide antibiotics are composed of amino acids, they often show little similarity to gene-encoded polypeptides in terms of structure and mechanism of their biosynthesis. Alternatively, an extensive reference survey was conducted for the peptides used as antibiotics, and some examples of antibiotics that are chemically composed of various amino acids and peptides were studied. Moreover, we focused in this review some selected examples of important peptide antibiotics, for example, bacitracin (I), gramicidin (II), monamycins, alafosfalin and albomycisn.

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Natural Antimicrobial Peptides from Eukaryotic Organisms

Cited by 4 publications

References 125 publications

Antimicrobial peptides as natural bio-preservative to enhance the shelf-life of food

Antimicrobial peptides as natural bio-preservative to enhance the shelf-life of food

Antimicrobial Peptides: Mechanism of Action

Peptide Chemistry's Role in Treating Most Serious Diseases: Peptide Antibiotics

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