Natural antibiotic susceptibility of strains of Serratia marcescens and the S. liquefaciens complex: S. liquefaciens sensu stricto, S. proteamaculans and S. grimesii

Stock, Ingo; Grueger, T.; Wiedemann, B.

doi:10.1016/s0924-8579(02)00163-2

Cited by 100 publications

(86 citation statements)

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“…Some strains of Serratia marcescens cause nosocomial infections that are clinically problematic because multidrug resistance is widespread within the species (Stock et al, 2003;Traub, 2000). S. marcescens has been isolated from soil, water, plants and air (Grimont & Grimont, 1978).…”

Section: Introductionmentioning

confidence: 99%

The Serratia gene cluster encoding biosynthesis of the red antibiotic, prodigiosin, shows species- and strain-dependent genome context variation

et al. 2004

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The prodigiosin biosynthesis gene cluster (pig cluster) from two strains of Serratia (S. marcescens ATCC 274 and Serratia sp. ATCC 39006) has been cloned, sequenced and expressed in heterologous hosts. Sequence analysis of the respective pig clusters revealed 14 ORFs in S. marcescens ATCC 274 and 15 ORFs in Serratia sp. ATCC 39006. In each Serratia species, predicted gene products showed similarity to polyketide synthases (PKSs), non-ribosomal peptide synthases (NRPSs) and the Red proteins of Streptomyces coelicolor A3(2). Comparisons between the two Serratia pig clusters and the red cluster from Str. coelicolor A3(2) revealed some important differences. A modified scheme for the biosynthesis of prodigiosin, based on the pathway recently suggested for the synthesis of undecylprodigiosin, is proposed. The distribution of the pig cluster within several Serratia sp. isolates is demonstrated and the presence of cryptic clusters in some strains shown. The pig cluster of Serratia marcescens ATCC 274 is flanked by cueR and copA homologues and this configuration is demonstrated in several S. marcescens strains, whilst these genes are contiguous in strains lacking the pig cluster.

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Section: Introductionmentioning

confidence: 99%

The Serratia gene cluster encoding biosynthesis of the red antibiotic, prodigiosin, shows species- and strain-dependent genome context variation

et al. 2004

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“…Recently, several fatal cases associated with nosocomial infections of this pathogen have been reported around the world (14,15). Among other antibiotics, it is naturally resistant to tetracycline, amoxicillin, amoxicillin-clavulanate, cephalothin, and colistin (16). The latter antibiotic is usually administered as a lastresort antibiotic for treatment of multidrug-resistant Pseudomonas aeruginosa, Acinetobacter baumannii, and Klebsiella pneumoniae infections in Argentina and many other countries (17).…”

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confidence: 99%

Outbreak of a Cluster with Epidemic Behavior Due to Serratia marcescens after Colistin Administration in a Hospital Setting

et al. 2013

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dSerratia marcescens causes health care-associated infections with important morbidity and mortality. Particularly, outbreaks produced by multidrug-resistant isolates of this species, which is already naturally resistant to several antibiotics, including colistin, are usually described with high rates of fatal outcomes throughout the world. Thus, it is important to survey factors associated with increasing frequency and/or emergence of multidrug-resistant S. marcescens nosocomial infections. We report the investigation and control of an outbreak with 40% mortality due to multidrug-resistant S. marcescens infections that happened from November 2007 to April 2008 after treatment with colistin for Acinetobacter baumannii meningitis was started at hospital H1 in 2005. Since that year, the epidemiological pattern of frequently recovered species has changed, with an increase of S. marcescens and Proteus mirabilis infections in 2006 in concordance with a significant decrease of the numbers of P. aeruginosa and A. baumannii isolates. A single pulsed-field gel electrophoresis (PFGE) cluster of S. marcescens isolates was identified during the outbreak. When this cluster was compared with S. marcescens strains (n ‫؍‬ 21) from 10 other hospitals (1997 to 2010), it was also identified in both sporadic and outbreak isolates circulating in 4 hospitals in Argentina. In132::ISCR1::bla CTX-M-2 was associated with the multidrug-resistant cluster with epidemic behavior when isolated from outbreaks. Standard infection control interventions interrupted transmission of this cluster even when treatment with colistin continued in several wards of hospital H1 until now. Optimizing use of colistin should be achieved simultaneously with improved infection control to prevent the emergence of species naturally resistant to colistin, such as S. marcescens and P. mirabilis.

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“…Serratia spp. are also generally resistant to ampicillin, amoxicillin, amoxicillin-clavulanate, ampicillin-sulbactam, first generation cephalosporins, cefuroxime, nitrofurantoin, colistin, and tetracyclines [29,31] . Therefore, it is recommended to start treatment for Serratia infections with piperacillin-tazobactam, fluoroquinolone, or carbapenem and to adjust treatment if necessary according to antibiotic susceptibility pattern [16] .…”

Section: Discussionmentioning

confidence: 99%

Posttraumatic Septic Arthritis Due to Serratia marcescens: Case Report and Review of Literature

Olut¹,

Tosun²,

Arı³

et al. 2018

mjima

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Septic arthritis is classified among the acute emergencies of joint diseases. Gram-positive cocci are responsible in 75-80% of the cases, while Gramnegative bacilli may be the etiological agents in case of compromised immunity, intravenous drug abuse, advanced age, or iatrogenic infections. Cases of posttraumatic septic arthritis due to Gram-negative bacilli in immunocompetent patients are reported in the literature. In this paper we present a severe septic arthritis due to Serratia marcescens in a 43-year-old man with multiple trauma, right patellar and femoral condyle fracture after a traffic accident, three days after an irrigation and debridement procedure was performed. The surgical procedure had to be repeated four times while he was receiving medical treatment. A literature search in PubMed using the keywords "Serratia marcescens and septic arthritis" on October 10 th 2017, we found 37 articles, of which 18 were case reports or case series. Of those 18 articles, seven cases were hospital-acquired, five were in intravenous drug users, two were trauma related, one was concomitant with rheumatoid arthritis, one was in a neonate, one was due to intra-articular injection, and one article described an epidemic due to usage of contaminated benzalkonium chloride solution as an antiseptic. We also found a case by searching Turkish Medline reported in a ten-week-old baby with Escobar syndrome. In our case, although hospital-acquired infection cannot be ruled out, we believe that this was a community-acquired infection due to contamination of the open dirty wound, as the irrigation procedure was done in sterile operating room conditions and no other such case has ever been identified. As prompt diagnosis and treatment is critical in prognosis of septic arthritis, we emphasize the possible role of Gram-negative bacilli in posttraumatic cases. Keywords: Septic arthritis, Serratia marcescens, posttraumatic, generic antibiotics, ertapenem Septik artrit, eklemle ilgili acil hastalıklar arasında sınıflandırılır. Erken tanı ve tedavi prognoz açısından oldukça önem taşır. Tüm olgularda en sık görülen etkenler %75-80 oranında Gram-olumlu koklardır. Ancak immün yetmezlik, damar içi ilaç alışkanlığı, ileri yaşlar veya iyatrojenik olgularda Gram-olumsuz basiller de etken olabilirler. Literatürde immünkompetan hastalarda da travma sonrası gelişen Gram-olumsuz basillere bağlı artritler bildirilmektedir. Bu yazıda trafik kazası sonucu multitravma, sağ patella ve sağ femoral kondil kırığı ile başvuran 43 yaşındaki erkek olguda debridman ve yıkama işlemi sonrasında üçüncü gün gelişen, Serratia marcescens'e bağlı şiddetli septik artrit olgusu sunulmuştur. Antibiyoterapi alırken cerrahi yıkama işleminin biri açık artrotomi olmak üzere dört kez tekrarlanması gerekmiştir. PubMed'de 10 Ekim 2017'de anahtar kelime olarak "Serratia marcescens ve septic arthritis" kullanılarak yapılan taramada 37 adet makale bulunmuş ve olgu bildiren 18 makale incelenmiştir. Makalelerin yedisi hastane kaynaklı, beşi damar içi ilaç alışkanlığı, ikisi travmay...

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Natural antibiotic susceptibility of strains of Serratia marcescens and the S. liquefaciens complex: S. liquefaciens sensu stricto, S. proteamaculans and S. grimesii

Cited by 100 publications

References 40 publications

The Serratia gene cluster encoding biosynthesis of the red antibiotic, prodigiosin, shows species- and strain-dependent genome context variation

The Serratia gene cluster encoding biosynthesis of the red antibiotic, prodigiosin, shows species- and strain-dependent genome context variation

Outbreak of a Cluster with Epidemic Behavior Due to Serratia marcescens after Colistin Administration in a Hospital Setting

Posttraumatic Septic Arthritis Due to Serratia marcescens: Case Report and Review of Literature

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