Natural and Synthetic Small Boron-Containing Molecules as Potential Inhibitors of Bacterial and Fungal Quorum Sensing

Dembitsky, Valery M.; Quntar, Abed Al Aziz Al; Srebnik, Morris

doi:10.1021/cr100093b

Cited by 183 publications

(85 citation statements)

References 255 publications

(241 reference statements)

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“…In this sense, some BCCs have notable antimicrobial activity on some pathogenic species, and some molecular targets have been identified on these microorganisms (proteasomes, penicillin binding proteins, carbonic anhydrases, synthetases, etc.). Consequently, some research groups have applied medicinal chemistry to use this selective cytotoxicity in order to improve the antimicrobial features of some BCCs (Baker, 2011;Dembitsky, 2011;Li, 2013;Onduka, 2013;Sanjoh, 2014;Fu, 2014).…”

Section: The Origins Of Avoidance Of Bccs In Medicinementioning

confidence: 99%

Current data regarding the structure-toxicity relationship of boron-containing compounds

et al. 2016

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Section: The Origins Of Avoidance Of Bccs In Medicinementioning

confidence: 99%

Current data regarding the structure-toxicity relationship of boron-containing compounds

et al. 2016

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“…It has been reported that boron inhibits bacterial quorum sensing 33) , which is a key factor in S. mutans biofilm formation 34) . In accord with this last report, we observed that EVA containing S-PRG filler inhibited the growth of S. mutans and the formation of biofilms in an S-PRG filler content-dependent manner.…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial activity of ethylene-vinyl acetate containing bioactive filler against oral bacteria

Nagai

Domon

Oda

et al. 2017

Dental Materials Journal

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We developed an ethylene vinyl acetate (EVA) containing surface pre-reacted glass-ionomer (S-PRG) filler, as a new mouthguard material for preventing intraoral bacterial infection. We examined its physical properties, antimicrobial activity against a major cariogenic bacterium Streptococcus mutans and a periodontopathogen Porphyromonas gingivalis, and its cytotoxicity toward human gingival epithelial cells. S-PRG filler was added to EVA copolymer at 5, 10, 20, or 40 wt% and was processed into disc-shaped test specimens. Only minor differences between the Shore hardness and rebound resilience properties of EVA materials with and without the S-PRG filler were observed. The specimens with S-PRG filler showed bacteriostatic activity toward S. mutans and P. gingivalis and inhibited S. mutans biofilm formation. No cytotoxicity against the gingival epithelial cells was observed. Our findings show that EVA containing S-PRG filler has antimicrobial activity toward pathogenic oral bacteria and may be an effective material for maintaining the oral health of athletes.

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“…Boron is known to have an antibacterial activity in cutaneous diseases and periodontitis [51,52], and inhibits bacterial and fungal quorum sensing [53]. Quorum sensing is a key factor in biofilm formation, so inhibition of this function in Streptococci may be a good candidate for the mechanism underlying the actions of S-PRG.…”

Section: Overall Review Of Antibacterial Activities Of S-prgmentioning

confidence: 99%

Antibacterial Effect of Surface Pre-Reacted Glass Ionomer Filler and EluateÂ–Mini Review

Yoneda

Suzuki²,

Hirofuji³

2015

Pharm Anal Acta

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A composite resin containing surface pre-reacted glass ionomer(S-PRG) has become widely used as filler or other dental materials in dental treatment. In this mini-review, we briefly summarizethe antibacterial activities of S-PRG on different oral bacteria. The inhibitory effect of S-PRG on plaque formation in the oral cavity has been observed. Streptococcus mutans adherence has been shown to be inhibited by S-PRG. S-PRG is also considered to be effective in caries prevention because S-PRG eluate could inhibit biofilm formation and disrupt salivary mature polymicrobial biofilm. S-PRG eluate has suppressed the protease and gelatinase activities of Porphyromonas gingivalis, which is one of the most important periodontopathic bacteria. Coaggregation by P. gingivali sand Fusobacterium nucleatum was also inhibited by S-PRG eluate. Other work has shown that an endodontic sealer containing S-PRGhad an antibacterial effect on some endodontic bacteria. Oral rinsing with S-PRG eluate was also effective in reducing oral malodor production. In this way, S-PRG has antibacterial effect, and it will be further applied for various dental materials and contribute to preventing oral diseases.

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Natural and Synthetic Small Boron-Containing Molecules as Potential Inhibitors of Bacterial and Fungal Quorum Sensing

Cited by 183 publications

References 255 publications

Current data regarding the structure-toxicity relationship of boron-containing compounds

Current data regarding the structure-toxicity relationship of boron-containing compounds

Antimicrobial activity of ethylene-vinyl acetate containing bioactive filler against oral bacteria

Antibacterial Effect of Surface Pre-Reacted Glass Ionomer Filler and EluateÂ–Mini Review

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