Natural and synthetic polymers for drug delivery and targeting

Mogoşanu, George Dan; Grumezescu, Alexandru Mihai; Bejenaru, Ludovic Everard; Bejenaru, Cornelia

doi:10.1016/b978-0-323-42866-8.00008-3

Cited by 22 publications

(14 citation statements)

References 468 publications

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“…Different polymers have played an important role in the advancement of microencapsulation technology by successfully ensuring the controlled release of active compounds and by providing an intrinsic therapeutic benefit. Both synthetic and natural polymers can be used as encapsulating agents [103,104].…”

Section: Natural Versus Synthetic Polymers For Polyphenol Carrier Designmentioning

confidence: 99%

“…Contrary to synthetic polymers, biopolymers are biodegradable and present enhanced biocompatibility. In addition, biopolymers allow the adhesion to target tissues, provide a neutral coating with low surface energy, are compatible with the environment, and possess specific receptor recognition [104]. However, there is a considerable level of variability among polymers derived from animal sources.…”

Section: Natural Versus Synthetic Polymers For Polyphenol Carrier Designmentioning

confidence: 99%

“…On the other hand, their extraction process can be complicated and costly [103]. Chitosan, hyaluronic acid, and alginate are examples of natural polymers commonly used in microparticulate systems for skin wound dressing and drug delivery [104]. Chitosan is one of the most used polymers as coating materials due to its cationic character based on its primary amino groups, which gives it extraordinary properties, such as controlled drug release, in situ gelation, and mucoadhesion [107].…”

Section: Natural Versus Synthetic Polymers For Polyphenol Carrier Designmentioning

confidence: 99%

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Polyphenols: A Promising Avenue in Therapeutic Solutions for Wound Care

et al. 2021

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In chronic wounds, the regeneration process is compromised, which brings complexity to the therapeutic approaches that need to be adopted, while representing an enormous loss in the patients’ quality of life with consequent economical costs. Chronic wounds are highly prone to infection, which can ultimately lead to septicemia and morbidity. Classic therapies are increasing antibiotic resistance, which is becoming a critical problem beyond complex wounds. Therefore, it is essential to study new antimicrobial polymeric systems and compounds that can be effective alternatives to reduce infection, even at lower concentrations. The biological potential of polyphenols allows them to be an efficient alternative to commercial antibiotics, responding to the need to find new options for chronic wound care. Nonetheless, phenolic compounds may have some drawbacks when targeting wound applications, such as low stability and consequent decreased biological performance at the wound site. To overcome these limitations, polymeric-based systems have been developed as carriers of polyphenols for wound healing, improving its stability, controlling the release kinetics, and therefore increasing the performance and effectiveness. This review aims to highlight possible smart and bio-based wound dressings, providing an overview of the biological potential of polyphenolic agents as natural antimicrobial agents and strategies to stabilize and deliver them in the treatment of complex wounds. Polymer-based particulate systems are highlighted here due to their impact as carriers to increase polyphenols bioavailability at the wound site in different types of formulations.

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Section: Natural Versus Synthetic Polymers For Polyphenol Carrier Designmentioning

confidence: 99%

Section: Natural Versus Synthetic Polymers For Polyphenol Carrier Designmentioning

confidence: 99%

Section: Natural Versus Synthetic Polymers For Polyphenol Carrier Designmentioning

confidence: 99%

See 1 more Smart Citation

Polyphenols: A Promising Avenue in Therapeutic Solutions for Wound Care

et al. 2021

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“…Currently, interdisciplinary research develops biocompatible and biodegradable drug delivery platforms made of synthetic, natural, and semisynthetic polymers to treat cutaneous inflammation, dysfunction, and infection. They seek to enhance the mechanical and physical characteristics of these materials regarding the efficiency of release [ 53 ]. There are multiple pharmacological factors that affect this, which result in a wide spectrum of properties.…”

Section: Carriers Of Nitric Oxide Donorsmentioning

confidence: 99%

Synthetic, Natural, and Semisynthetic Polymer Carriers for Controlled Nitric Oxide Release in Dermal Applications: A Review

2021

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Nitric oxide (NO•) is a free radical gas, produced in the human body to regulate physiological processes, such as inflammatory and immune responses. It is required for skin health; therefore, a lack of NO• is known to cause or worsen skin conditions related to three biomedical applications— infection treatment, injury healing, and blood circulation. Therefore, research on its topical release has been increasing for the last two decades. The storage and delivery of nitric oxide in physiological conditions to compensate for its deficiency is achieved through pharmacological compounds called NO-donors. These are further incorporated into scaffolds to enhance therapeutic treatment. A wide range of polymeric scaffolds has been developed and tested for this purpose. Hence, this review aims to give a detailed overview of the natural, synthetic, and semisynthetic polymeric matrices that have been evaluated for antimicrobial, wound healing, and circulatory dermal applications. These matrices have already set a solid foundation in nitric oxide release and their future perspective is headed toward an enhanced controlled release by novel functionalized semisynthetic polymer carriers and co-delivery synergetic platforms. Finally, further clinical tests on patients with the targeted condition will hopefully enable the eventual commercialization of these systems.

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“…3 So far, a diverse range of non-natural and natural-based polymers with different applications such as catalysis with high yield efficiency [4][5][6] and adsorption of heavy metal ions 7 have been applied. On the other hand, different biomedical approaches such as tissue engineering, 8,9 drug delivery systems, [10][11][12] hyperthermia cancer therapy, 13,14 and wound healing 15,16 have been exclusively developed by using these types of material. Also, the formation of polymer-based nanomaterials as new biosensing probes has led to advanced detection of pathogenic viruses, 17,18 toxic mycotoxins, 19 neurotoxic proteins, 20 and cancer biomarkers.…”

Section: Introductionmentioning

confidence: 99%