Natural and Synthetic Biopolymers in Drug Delivery and Tissue Engineering

Schneible, John D.; Daniele, Michael A.; Menegatti, Stefano

doi:10.1002/9783527818310.ch9

Cited by 5 publications

(7 citation statements)

References 935 publications

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“…Drug-resistant cancer cell lines may be treated using Dextran nanogels that carry siRNA to silence the genes that cause multidrug resistance. 192 Fast-dissolving oral medication administration was achieved by electrospinning metronidazole/ hydroxypropyl-b-cyclodextrin inclusion complex nanobrous webs. 312 For complexation, cyclodextrins are most oen used.…”

Section: Polysaccharides Based Ddsmentioning

confidence: 99%

“… 109 They are proved prospective carriers for butyric acid to treat Lewis lung, melanoma, and leukaemia and have undergone significant research for the transport of analgesics, siRNA, proteins, antibiotics and anticancer medicines. 192 In human ovarian carcinoma xenografts, hyaluronic acid (HA) alone and in conjugation with DOX demonstrated targeted toxicity in vitro and potent anticancer action in vivo 193 and bladder carcinoma respectively. 194 HA functionalized by adipic dihydrazide or methacrylic anhydride showed an appreciable DD profile.…”

Section: Formulations Of Biopolymers and Their Compositesmentioning

confidence: 99%

“…On a group of human tumour xenografts and colon cancer, a dextran–camptothecin combination demonstrated strong anticancer efficacy in vivo . 192 A combination of dextran and exatecan demonstrated substantial therapeutic effectiveness against a panel of murine solid tumours and human xenografts. 307 Compared to the free medication, methotrexate to dextran combination demonstrated enhanced activity against human tumour xenograft models.…”

Section: Formulations Of Biopolymers and Their Compositesmentioning

confidence: 99%

“… 309 In a Lewis lung cancer rat model, an imine conjugation of DOX to Ox-dextran shown greater therapeutic effectiveness. 192 Additionally, a clinical investigation for a CM-dextran combination with delimotecan has begun. 310 Dextran nanogels that have been PEGylated have been used for gene therapy using short interfering RNA, 311 which, in human hepatoma and glioblastoma, have effectively accomplished gene knockdown.…”

Section: Formulations Of Biopolymers and Their Compositesmentioning

confidence: 99%

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Recent developments in natural biopolymer based drug delivery systems

Fazal

Murtaza

Shah³

et al. 2023

RSC Adv.

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Section: Polysaccharides Based Ddsmentioning

confidence: 99%

Section: Formulations Of Biopolymers and Their Compositesmentioning

confidence: 99%

Section: Formulations Of Biopolymers and Their Compositesmentioning

confidence: 99%

Section: Formulations Of Biopolymers and Their Compositesmentioning

confidence: 99%

See 2 more Smart Citations

Recent developments in natural biopolymer based drug delivery systems

Fazal

Murtaza

Shah³

et al. 2023

RSC Adv.

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“…From this perspective, biopolymers are very attractive because of their affinity with cell membranes, low toxicity, ease of preparation and structural tunability that make them ideal materials for the design of controlled drug delivery systems [8][9][10]. Lipid nanoparticles, in particular, proved to be effective in enhancing the availability of even poorly soluble molecules due to their aptitude to promote the formation of solubilized phases during digestion [11,12].…”

Section: Introductionmentioning

confidence: 99%

Tailoring Lipid-Based Drug Delivery Nanosystems by Synchrotron Small Angle X-ray Scattering

Sartori

Marmiroli

2022

Pharmaceutics

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Thanks to specific physico-chemical properties, drug delivery systems based on nanoparticles have proven to effectively transport delicate molecules for therapeutic purposes, protecting them from degradation, increasing their stability in the blood circulation and allowing to convey and release the transported substances in specific areas of the body. Nanoparticles obtained from biopolymers for applications in medicine and pharmaceutics have become particularly popular in recent years due to the enormous research effort in the field of vaccines to respond to the pandemic emergency. Among the various types of biopolymers used to produce nanoparticles for therapeutics, lipids have characteristics that make them biocompatible, with low toxicity and ease of clearance. They can be synthesized by designing their characteristics according to the foreseen administration path, or to the target of the transported drug. The analytical methods mostly used to evaluate the characteristics of lipid nanosytems for drug delivery involve studying their effects on cells, in vitro and in vivo. Although it is often considered a “niche technique“ for research in the bio-related sciences, Small Angle X-ray Scattering (SAXS) is a versatile tool to study the structure of nanosystems based on lipids, both ex situ and in situ. Therefore, it allows to evaluate both the effect of the different synthesis parameters and of the exposure of lipid nanoparticles to physiological conditions, which is of fundamental importance to design efficient drug delivery systems. In this mini-review, we will report some recent examples of characterization and design of nanoparticles based on lipids, where SAXS has been a fundamental step both to guide the synthesis of nanomaterials with tailored characteristics, and to understand the interaction between nanomaterials and cells.

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