Natural and semisynthetic polymers blended orodispersible films of citalopram

Shahzad, Yasser; Maqbool, Maimoona; Hussain, Talib; Yousaf, Abid Mehmood; Khan, Ikram Ullah; Mahmood, Tariq; Jamshaid, Muhammad

doi:10.1080/14786419.2018.1552698

Cited by 12 publications

(8 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The total time taken by the film to disintegrate was noted using a digital stopwatch. 26 The procedure was performed in triplicate.…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Gellan Gum-Based Bilayer Mucoadhesive Films Loaded with Moxifloxacin Hydrochloride and Clove Oil for Possible Treatment of Periodontitis

Khan

et al. 2021

DDDT

Self Cite

View full text Add to dashboard Cite

Background/Objective: Periodontitis is a widely spread oral infection and various antibiotics are utilized for its treatment, but high oral doses and development of antibiotic resistance limit their use. This study was aimed at development of natural polymer-based mucoadhesive bilayer films loaded with moxifloxacin hydrochloride (Mox) and clove essential oil (CEO) to potentially combat bacterial infection associated with periodontitis. Methods: Films were synthesized by double solvent casting technique having an antibiotic in the gellan gum-based primary layer with clove oil in a hydroxyethyl cellulose-based secondary layer. Results: Prepared films were transparent, flexible, and showed high antibacterial response against both gram-positive and gram-negative bacteria. The films showed excellent pharmaceutical attributes in terms of drug content, folding endurance, swelling index, and mucoadhesive strength. Solid state characterization of formulation showed successful incorporation of drug and oil in separate layers of hydrogel structure. An in-vitro release study showed an initial burst release of drug followed by sustained release for up to 48 hours. Conclusion:The prepared mucoadhesive bilayer buccal films could be used as a potential therapeutic option for the management of periodontitis.

show abstract

“…The total time taken by the film to disintegrate was noted using a digital stopwatch. 26 The procedure was performed in triplicate.…”

Section: Methodsmentioning

confidence: 99%

“…The total time taken by the film to disintegrate was noted using a digital stopwatch. 26 The procedure was performed in triplicate. A folding endurance test was performed to check the mechanical properties of formulated films.…”

Section: Antibacterial Activitymentioning

confidence: 99%

Gellan Gum-Based Bilayer Mucoadhesive Films Loaded with Moxifloxacin Hydrochloride and Clove Oil for Possible Treatment of Periodontitis

Khan

et al. 2021

DDDT

Self Cite

View full text Add to dashboard Cite

show abstract

“…For the production of ODFs, pullulan is used due to its good filmforming properties; however, pullulan has a high cost, so it is usually blended with synthetic, semi-synthetic, and natural polymers to decrease cost and improve other properties. Literature shows pullulan ODFs blended with HPMC [37,47,48], pectin [47,49], maltodextrin [50], polyvinylpyrrolidone (PVP) [51], trehalose [52] and okra biopolymer [48]. Also, fillers such as cellulose nanofibers (CNF) were proposed to improve the compatibility, and tensile strength of pullulan/HPMC blended ODFs [37].…”

Section: Pullulanmentioning

confidence: 99%

“…Some studies on pullulan ODFs also analyzed the influence of the drug in the film's properties, using isoniazid [47], influenza vaccine (H5N1) [39], citalopram [48], dihydroergotamine mesylate [50], ebastine [21], captopril [37], potassium diclofenac [54], donepezil hydrochloride [56], tetrabenazine [57,58], levocetirizine dihydrochloride [59], griseofulvin [60], aprepitant [49] and sodium diclofenac [51]. Pullulan-based ODFs have also been used as class II drug carrier, which has high permeability and low solubility.…”

Section: Pullulanmentioning

confidence: 99%

A review on orally disintegrating films (ODFs) made from natural polymers such as pullulan, maltodextrin, starch, and others

Pacheco

Barbieri

Silva

et al. 2021

International Journal of Biological Macromolecules

View full text Add to dashboard Cite

“…The disintegration time was less than 30 s and the homogeneity of the drug content was 97.89-102.05% for all formulations. Additionally, the films made of okra gum and HPMC were characterized by superior mechanical properties compared to okra and pullulan blend or moringa gum and HPMC mixture [68,69].…”

Section: Chitosanmentioning

confidence: 99%

“Success Depends on Your Backbone”—About the Use of Polymers as Essential Materials Forming Orodispersible Films

2021

View full text Add to dashboard Cite

Polymers constitute a group of materials having a wide-ranging impact on modern pharmaceutical technology. Polymeric components provide the foundation for the advancement of novel drug delivery platforms, inter alia orodispersible films. Orodispersible films are thin, polymeric scraps intended to dissolve quickly when put on the tongue, allowing them to be easily swallowed without the necessity of drinking water, thus eliminating the risk of choking, which is of great importance in the case of pediatric and geriatric patients. Polymers are essential excipients in designing orodispersible films, as they constitute the backbone of these drug dosage form. The type of polymer is of significant importance in obtaining the formulation of the desired quality. The polymers employed to produce orodispersible films must meet particular requirements due to their oral administration and have to provide adequate surface texture, film thickness, mechanical attributes, tensile and folding strength as well as relevant disintegration time and drug release to obtain the final product characterized by optimal pharmaceutical features. A variety of natural and synthetic polymers currently utilized in manufacturing of orodispersible films might be used alone or in a blend. The goal of the present manuscript was to present a review about polymers utilized in designing oral-dissolving films.

show abstract

Natural and semisynthetic polymers blended orodispersible films of citalopram

Cited by 12 publications

References 29 publications

Gellan Gum-Based Bilayer Mucoadhesive Films Loaded with Moxifloxacin Hydrochloride and Clove Oil for Possible Treatment of Periodontitis

Gellan Gum-Based Bilayer Mucoadhesive Films Loaded with Moxifloxacin Hydrochloride and Clove Oil for Possible Treatment of Periodontitis

A review on orally disintegrating films (ODFs) made from natural polymers such as pullulan, maltodextrin, starch, and others

“Success Depends on Your Backbone”—About the Use of Polymers as Essential Materials Forming Orodispersible Films

Contact Info

Product

Resources

About