“…The immune population landscape may also shape the impact of new SARS-CoV-2 variants. Previous studies demonstrate that “hybrid immunity”, produced by a combination of infection and SARS-CoV-2 vaccination, improves the potency, breadth, and durability of serum neutralizing activity against SARS-CoV-2 variants, including Delta and Omicron, relative to either infection or vaccination alone (Andreano et al, 2021; Bates et al, 2022; Gazit et al, 2022; Goldberg et al, 2022; Hall et al, 2022; Hammerman et al, 2022; Cerqueira-Silva et al, 2022a; Wang et al, 2021; Wratil et al, 2022; Cele et al, 2021; Planas et al, 2021; Rössler et al, 2022; Walls et al, 2022; Gruell et al, 2022; Nielsen et al, 2022; Zar et al, 2022; Altarawneh et al, 2022a). Thus, populations with high hybrid immunity walls are expected to have a better protection against the impact of new SARS-CoV-2 variants carrying immune escape mutations (Crotty, 2021; Suryawanshi & Ott, 2022).…”