Natural and bioderived molecular gelator–based oleogels and their applications

Sagiri, Sai Sateesh; Rao, K. Jagajjanani

doi:10.1016/b978-0-12-816897-4.00022-9

Cited by 10 publications

(7 citation statements)

References 143 publications

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“…On the other hand, gelator‐solvent interactions were mediated by apolar tail groups (Gaudino et al, 2019). This kind of interaction can only be possible with the inverse micellar assembly of gelators (Sagiri & Rao, 2020). The molecular association of gelators as inverse micelles (primary structures) and their propagation as bilayers (secondary structures) lead to the formation of the fibrous network (tertiary structures).…”

Section: Resultsmentioning

confidence: 99%

Self‐assembled trehalose amphiphiles as molecular gels: A unique formulation to wax‐free cosmetics

Tsupko

Sagiri

Samateh

et al. 2023

J Surfact & Detergents

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Trehalose has been used as an emollient and antioxidant in cosmetics. We aimed to explore trehalose amphiphiles as oil structuring agents for the preparation of gel‐based lip balms as part of wax‐free cosmetics. This article describes the synthesis of trehalose fatty acyl amphiphiles and their corresponding oleogel‐based lip balms. Trehalose dialkanoates were synthesized by esterifying the two primary hydroxyls of trehalose with fatty acids (C4‐C12) using a facile, regioselective lipase catalysis. The gelation potential of as‐synthesized amphiphiles was evaluated in organic solvents and vegetable oils. Stable oleogels were subjected to X‐ray diffraction (XRD), thermal (DSC), and rheological studies and further used for the preparation of lip balms. Trehalose dioctanoate (Tr8), trehalose didecanoate (Tr10) were found to be super gelators as their minimum gelation concentration is ≤0.2 wt%. XRD studies revealed their hexagonal columnar molecular packing while forming the fibrillar networks. Rheometry proved that the fatty acyl chain length of amphiphiles can influence the strength and flow properties of oleogels. Further rheometry (at 25, 37, and 50 °C) and DSC studies have validated that Tr8‐ and Tr10‐based oleogels are stable for commercial applications. Tr8‐ and Tr10‐based olive oil oleogels were used for the preparation of lip balms. The preliminary results suggested that the cumulative effect of trehalose's emolliency and vegetable oil gelling nature can be achieved with trehalose amphiphiles, specifically, Tr8 and Tr10. This study has also demonstrated that Tr8‐ and Tr10‐based lip balms can be used as an alternative to beeswax and plant wax lip balms, indicating their huge potential to succeed as a new paradigm to formulate wax‐free cosmetics.

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Section: Resultsmentioning

confidence: 99%

Self‐assembled trehalose amphiphiles as molecular gels: A unique formulation to wax‐free cosmetics

Tsupko

Sagiri

Samateh

et al. 2023

J Surfact & Detergents

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“…A similar wax concentration has been reported to structure soyabean oil, which is commonly used to replace saturated fats in food products [ 10 ]. Waxes containing a long chain of alkanes and esters are much more efficient in vegetable oil gel than waxes made of short-chain alkanes [ 21 ]. Many natural waxes such as carnauba wax, candelilla wax, and beeswax, etc., have been reported as an efficient oleogelator because of their ability to crystallize the vegetable oil at lower concentrations [ 22 ].…”

Section: Resultsmentioning

confidence: 99%

Effect of Biodegradable Hydrophilic and Hydrophobic Emulsifiers on the Oleogels Containing Sunflower Wax and Sunflower Oil

Bharti

Kim

Cerqueira

et al. 2021

Gels

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The use of an appropriate oleogelator in the structuring of vegetable oil is a crucial point of consideration. Sunflower wax (SFW) is used as an oleogelator and displays an excellent potential to bind vegetable oils. The current study aimed to look for the effects of hydrophobic (SPAN-80) and hydrophilic (TWEEN-80) emulsifiers on the oleogels prepared using SFW and sunflower oil (SO). The biodegradability and all formulations showed globular crystals on their surface that varied in size and number. Wax ester, being the most abundant component of SFW, was found to produce fibrous and needle-like entanglements capable of binding more than 99% of SO. The formulations containing 3 mg of liquid emulsifiers in 20 g of oleogels showed better mechanical properties such as spreadability and lower firmness than the other tested concentrations. Although the FTIR spectra of all the formulations were similar, which indicated not much variation in the molecular interactions, XRD diffractograms confirmed the presence of β′ form of fat crystals. Further, the mentioned formulations also showed larger average crystallite sizes, which was supported by slow gelation kinetics. A characteristic melting point (Tm~60 °C) of triglyceride was visualized through DSC thermograms. However, a higher melting point in the case of few formulations suggests the possibility of even a stable β polymorph. The formed oleogels indicated the significant contribution of diffusion for curcumin release. Altogether, the use of SFW and SO oleogels with modified properties using biodegradable emulsifiers can be beneficial in replacing saturated fats and fat-derived products.

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“…organic solvents could be of natural origin, e.g., sunflower oil, mustard oil, etc. 53,64 a raw material like lecithin is not available on a large scale 58 2.1.2. Nonbirefringence.…”

Section: Organogelsmentioning

confidence: 99%

Lecithin Organogel: A Promising Carrier for the Treatment of Skin Diseases

Raut,

Azheruddin,

Kumar

et al. 2024

ACS Omega

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Skin is the largest organ of the human body, as it protects the body from the external environment. Nowadays, skin diseases and skin problems are more common, and millions of people are affected daily. Skin diseases are due to numerous infectious pathogens or inflammatory conditions. The increasing demand for theoretical research and practical applications has led to the rising prominence of gel as a semisolid material. To this end, organogels has been widely explored due to their unique composition, which includes organic solvents and mineral or vegetable oils, among others. Organogels can be described as semisolid systems wherein an organic liquid phase is confined within a three-dimensional framework consisting of self-assembled, cross-linked, or entangled gelator fibers. These gels have the ability to undergo significant expansion and retain substantial amounts of the liquid phase, reaching up to 99% swelling capacity. Furthermore, they respond to a range of physical and chemical stimuli, including temperature, light, pH, and mechanical deformation. Notably, due to their distinctive properties, they have aroused significant interest in a variety of practical applications. Organogels favor the significant encapsulation and enhanced permeation of hydrophobic molecules when compared with hydrogels. Accordingly, organogels are characterized into lecithin organogels, pluronic lecithin organogels, sorbitan monostearate-based organogels, and eudragit organogels, among others, based on the nature of their network and the solvent system. Lecithin organogels contain lecithin (natural and safe as a living cell component) as an organogelator. It acts as a good penetration enhancer. In this review, first we have summarized the fundamental concepts related to the elemental structure of organogels, including their various forms, distinctive features, methods of manufacture, and diverse applications. Nonetheless, this review also sheds light on the delivery of therapeutic molecules entrapped in the lecithin organogel system into deep tissue for the management of skin diseases and provides a synopsis of their clinical applications.

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Natural and bioderived molecular gelator–based oleogels and their applications

Cited by 10 publications

References 143 publications

Self‐assembled trehalose amphiphiles as molecular gels: A unique formulation to wax‐free cosmetics

Self‐assembled trehalose amphiphiles as molecular gels: A unique formulation to wax‐free cosmetics

Effect of Biodegradable Hydrophilic and Hydrophobic Emulsifiers on the Oleogels Containing Sunflower Wax and Sunflower Oil

Lecithin Organogel: A Promising Carrier for the Treatment of Skin Diseases

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