Ensuring
food safety is a never-ending challenge. Developing time–temperature
indicators (TTIs) having biobased temperature-responsive colorants
(TCs) is an effective method for improving food safety. However, these
colorants still suffer from limitations, including difficulty in scaling
up for industrial production, imposing pressure on edible resources,
and poor thermal stability, which seriously impedes their wide use
in TTIs. Here, a new generation of biobased TCs based on furfural,
featuring high yield, color tunability, reversible color change, and
high thermal stability, are demonstrated. After doping them into a
plant oil-based polyurethane, the resulting biobased film and corresponding
TTI enable us to monitor the thermal history of food stored in the
refrigerator precisely and improve food safety before consuming by
visual color change. In addition to high biocontent, lightweight,
and flexibility, the designed TTIs possess color tunability, durability,
reusability, waterproofing ability, and cost efficiency, thus providing
a significant step closer to their wide use and sustainability. This
work represents an important complement to modern food packaging technology
for improving food safety.