Natural and Acquired Resistance of Klebsiella-Aerobacter to Cephalothin and Cephaloridine.

Clinical and Laboratory Evaluation of a New Cephalosporin Antibiotic, Cephaloridine

“…The finding [7,16] that motile strains (Aerobacter) of KlebsiellaAerobacter are prevalently resistant to Cephaloridine has been confirmed in the present study, as in our previous work on Cephalothin [1]. On the other hand, we have found that non-motile strains (Klebsiella) are preva lently susceptible to these agents.…”

“…On the other hand, altera tions in the size of the inoculum exerted less effect on the MIC of peni cillin-sensitive Staphylococci. These last results are in contrast to those obtained with sodium Ceph alothin which is equally active against both penicillin-sensitive and penicillin-resistant Staphylococci, and suggest that Cephaloridine may be less effective against certain strains because it is more susceptible to staph ylococcal /J-lactamase [7,22], As far as gram-negative bacteria are concerned, Cephaloridine shows greater activity than sodium Cephalothin against E. coli (65 % of strains are inhibited by 12.5 ,Mg/mI of the drug or less); Klebsiella (66.6 %>) and Proteus mirabilis (100 %>) strains. There was less significant difference between the two antibiotics with other gram-negative bacilli: particularly, Cephaloridine inhibits 33.3 °/o of Aerobacter, 83.3 °/o of Salmonella typhi strains, while it is not active against indole-positive Proteus and Pseudo monas aeruginosa strains.…”

“…Increased resistance was observed in organisms isolated from patients unsuccessfully treated [1,6,7], As far as the tolerance and toxicity data are concerned, Cephaloridine given intramuscularly rarely produced excessive pain at the site of injec tion.…”

Simultaneous determination of erythromycin ethylsuccinate and its metabolite erythromycin in human plasma using liquid chromatography–electrospray ionization mass spectrometry for clinical study

“…Microbiological analytical method has been widely used [4,[7][8][9][10]. But it suffers a poor specificity and a relatively high limit of detection.…”

Sodium Clavulanate Potentiation of Cephalosporin Activity Against Clinical Isolates of Cephalothin-Resistant Klebsiella pneumoniae

“…However, high-level natural resistance of a minority of strains and ease of induction of resistance in the presence of subinhibitory concentrations of cephalosporins in vitro led to the prediction that cephalosporin-resistant Klebsiella would likely become prevalent (1). Resistance among Klebsiella to beta-lactam antibiotics, which has become increasingly prevalent among clinical isolates of gram-negative bacilli (2), results largely from beta-lactamase.…”