Natural alkaloid and polyphenol compounds targeting lipid metabolism: Treatment implications in metabolic diseases

Cheng, Chunxia; Li, Zhenzhen; Zhao, Xu; Liao, Chaoliang; Quan, Jing; Bode, Ann M.; Cao, Yang

doi:10.1016/j.ejphar.2020.172922

Cited by 47 publications

(37 citation statements)

References 69 publications

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“…Lipids play an important role in providing energy and essential fatty acids, as well as becoming indispensable components of cells and tissues, such as cell membranes and myelin in human body. Once abnormalities in lipid anabolism and lipid catabolism occur, the metabolic disorder will occur in the organism (Cheng et al, 2020). Therefore, we describe the regulatory machinery of lipid metabolism, and summarize the pharmacological effects of FSBT in regulating lipid metabolism.…”

Section: Lipid Metabolismmentioning

confidence: 99%

Flavonoids from sea buckthorn: A review on phytochemistry, pharmacokinetics and role in metabolic diseases

et al. 2021

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Sea buckthorn (Hippophae rhamnoides L., SBT) is being used as a folk medicine for their diverse medicinal properties. Flavonoids are generally considered as the main bioactive and characteristic ingredients in SBT. This review was conducted using a comprehensive literature search on the chemical components, quality control, pharmacokinetics of flavonoids from SBT (FSBT). Particularly, we highlighted the therapeutic potential in metabolic diseases and clinical applications of FSBT. More than 95 flavonoids have been identified from SBT. Although the oral bioavailability of FSBT was relatively low, FSBT displays significant effect on the regulation of metabolism to ameliorate metabolic disorders and their complications. There is a heightened need to explore the bioactive compounds in SBT and mechanism(s) of action of FSBT in order to fully understand the pathways of their activities. Practical applicationsFor years, due to the increasing emergence of metabolic syndrome and diverse functions of FSBT in regulating metabolism, they can be efficiently utilized for human health and have an urgent need to become a hotspot for research. This review will broaden the understanding of FSBT, providing some directions for further development and expanding the therapeutic applications of FSBT.

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Section: Lipid Metabolismmentioning

confidence: 99%

Flavonoids from sea buckthorn: A review on phytochemistry, pharmacokinetics and role in metabolic diseases

et al. 2021

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“…Currently, some alkaloids have been utilized as main components of drugs for treatment of a certain disease, which is beneficial for further investigations on their biological activities and medicinal prospects. [5][6][7] At present, several reviews were published on the topic of alkaloids isolated from various marine sponge genus. In 2015, Sfecci et al expounded chemodiversity and bioactivities of batzelladine-and crambescidin-like guanidine alkaloids isolated from Poecilosclerida marine sponges in 1989 -2015, suggesting that remarkable structural diversity of polycyclic guanidine alkaloids led to a wide range of biological characteristics from genus of Poecilosclerida.…”

Section: Introductionmentioning

confidence: 99%

“…Alkaloids are cyclic molecules with negatively oxidized nitrogen atoms in organisms, which possess potent pharmacological activities, especially heterocyclic alkaloids that inhibit the activities of bacteria, fungi, protozoa, and so forth, for its unique scaffold. Currently, some alkaloids have been utilized as main components of drugs for treatment of a certain disease, which is beneficial for further investigations on their biological activities and medicinal prospects [5–7] …”

Section: Introductionmentioning

confidence: 99%

Recent Advances on Marine Alkaloids from Sponges

Bian

Wang

Zhou

et al. 2020

Chemistry & Biodiversity

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Alkaloids from marine secondary metabolites have received extensive attention from pharmacists in recent years. Miscellaneous alkaloids derived from marine sponges possessed various pharmacological activities including cytotoxicity, antimicrobial, antioxidant, and so on. Herein, we summarized 149 marine alkaloids from sponges based on their structures and bioactivities reported from 2015 to 2020 and analyzed the production environment of marine sponges with rich alkaloids. Moreover, we discussed biosynthesis routes of pyrrole and guanidine alkaloids from marine sponges Agelas and Monanchora. This article will be beneficial for future research on drugs from marine natural products.

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“…Moreover, recent reports have linked obesity to high severity in COVID-19 infected patients [8]. As there are very limited non-surgical therapeutic options and in view of the immense demand for drugs to treat obesity and NAFLD and considering the adverse effects associated with existing drugs, research efforts to develop natural product-based therapeutics have drawn much attention [9,10,11]. In our previous study, we reported the anti-hyperlipidemic activity of bark extract of Bauhinia purpurea Linn.…”

mentioning

confidence: 99%

Bauhiniastatin-1 alleviates diet induced obesity and lipid accumulation through modulating PPAR-γ/AMPK expressions: In-vitro, in-vivo and in-silico studies.

Sankaran

Oruganti

Ganjayi

et al. 2021

Preprint

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Background: Consumption of energy dense foods and sedentary lifestyles have led to high prevalence of obesity and associated disorders. Intensive research efforts have focussed to develop effective alternative therapeutics from plant sources. Bauhiniastatins have been reported to possess antineoplastic activity. In the present study, Bauhiniastatin-1 (BSTN1) was isolated and purified from Bauhinia purpurea and evaluated for its therapeutic efficacy against adipogenesis and obesity using high fat diet (HFD)-induced obese rodent model and 3T3-L1 cells.Methods: We performed in-vitro experiments like MTT assay, Oil Red O (ORO) stain, cellular lipid content, glycerol release and RT-PCR analysis in 3T3-L1 cells. In-vivo parameters like body weight gain, body composition, plasma adipokines, serum & liver lipid profiles, liver marker enzymes, western blot analysis and histopathological examination were conducted in rat model. In addition, molecular docking studies were also performed to understand interaction of BSTN1 with peroxisome proliferator-activated gamma receptor (PPAR-γ) and AMP-activated protein kinase (AMPK) which supported our experimental results.Results: BSTN1 at 20 μM significantly (p<0.001) inhibited cell differentiation and lipid accumulation of 3T3-L1 adipocytes. Mechanistic studies showed that mRNA expression of key adipogenic markers, PPAR-γ, fatty acid synthase (FAS) and sterol-regulatory element-binding protein-1 (SREBP1) were down-regulated while AMPK was up-regulated by BSTN1. Oral administration of BSTN1 (5 mg/kg. b.wt.) to HFD-induced obese rats substantially decreased body weight gain, fat mass, serum and liver lipid levels and promoted integrity of hepatic and adipose tissue architecture compared to HFD-control rats. In BSTN1 administered groups, decreased serum aspartate transaminase (AST) and alanine aminotransferase (ALT) levels, decreased plasma leptin but increased adiponectin levels were noted. Western blot analysis of adipose and hepatic tissues collected from BSTN1 treated rats showed decreased expression level of PPAR-γ but increase in AMPK expression relative to the untreated group. In-silico studies showed strong binding interactions of BSTN1 against PPAR-γ and AMPK, the key molecules of adipogenesis and obesity.Conclusions: Taken together, the results suggest that BSTN1 could be promising molecule for the treatment of diet-induced obesity and non-alcoholic fatty liver disease (NAFLD).

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Natural alkaloid and polyphenol compounds targeting lipid metabolism: Treatment implications in metabolic diseases

Cited by 47 publications

References 69 publications

Flavonoids from sea buckthorn: A review on phytochemistry, pharmacokinetics and role in metabolic diseases

Flavonoids from sea buckthorn: A review on phytochemistry, pharmacokinetics and role in metabolic diseases

Recent Advances on Marine Alkaloids from Sponges

Bauhiniastatin-1 alleviates diet induced obesity and lipid accumulation through modulating PPAR-γ/AMPK expressions: In-vitro, in-vivo and in-silico studies.

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