Natural aging as as a sequential poly-systemic syndrome

Krut’ko, V. N.; Dontsov, V. I.; Khalyavkin, A. V.; Markova, A. M.

doi:10.2741/4624

Cited by 14 publications

(5 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Aging is a multidimensional phenomenon that includes physiological, psychosocial, and biological changes (5). Aging is defined as a continuous process under cumulative, progressive, intrinsic, and deleterious factors (6,7). Frailty is an important concept in the science of aging and a very common aging syndrome (8).…”

Section: Introductionmentioning

confidence: 99%

“… 5 ) Aging is defined as a continuous process under cumulative, progressive, intrinsic, and deleterious factors. 6 , 7 ) Frailty is an important concept in the science of aging and a very common aging syndrome. 8 ) Frailty is defined as a state of increased vulnerability due to reduced physiological reserves and function in different organ systems when exposed to stress in individuals of the same chronological age.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The Impact of the Otago Exercise Program on Frailty and Empowerment in Older Nursing Home Residents: A Randomized Controlled Trial

Şahin

Aykar²,

Yıldırım

et al. 2022

Ann Geriatr Med Res

View full text Add to dashboard Cite

Ethical approval:The study protocol was approved by the Ethics Committee of Ege University Faculty of Medicine (Number 70198063-050.06.04). All procedures performed in studies involving human participants were in accordance with the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards .Informed consent: All of the patients were informed of the study protocols in detail and provided their informed written consent .

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Impact of the Otago Exercise Program on Frailty and Empowerment in Older Nursing Home Residents: A Randomized Controlled Trial

Şahin

Aykar²,

Yıldırım

et al. 2022

Ann Geriatr Med Res

View full text Add to dashboard Cite

show abstract

“…Some researchers have suggested that the aging process is affected by environmental [2, 3], nutritional [4], and genetic factors [5] and have attempted to explore the mechanisms of aging. In addition, in modern times, an increasing number of aging-related diseases, such as cancer, cardiovascular disease, chronic degenerative diseases and other aging-related dysfunctions, have threatened human health [6, 7]. Even though increasing evidence has demonstrated that pharmacological intervention may delay the senescence process [8, 9], a definitely effective antiaging treatment has not yet been found since the mechanisms of aging are complicated.…”

Section: Introductionmentioning

confidence: 99%

Antiaging effect of a Jianpi-yangwei formula in Caenorhabditis elegans

Zeng

Yang

Yun

et al. 2019

BMC Complement Altern Med

View full text Add to dashboard Cite

BackgroundJianpi-yangwei (JPYW), a traditional Chinese medicine (TCM), helps to nourish the stomach and spleen and is primarily used to treat functional declines related to aging. This study aimed to explore the antiaging effects and mechanism of JPYW by employing a Caenorhabditis elegans model.MethodsWild-type C. elegans N2 worms were cultured in growth medium with or without JPYW, and lifespan analysis, oxidative and heat stress resistance assays, and other aging-related assays were performed. The effects of JPYW on the levels of superoxide dismutase (SOD) and the expression of specific genes were examined to explore the underlying mechanism of JPYW.ResultsCompared to control worms, JPYW-treated wild-type worms showed increased survival times under both normal and stress conditions (P < 0.05). JPYW-treated worms also exhibited enhanced reproduction, movement and growth and decreased intestinal lipofuscin accumulation compared to controls (P < 0.05). Furthermore, increased activity of SOD, downregulated expression levels of the proaging gene clk-2 and upregulated expression levels of the antiaging genes daf-16, skn-1, and sir-2.1 were observed in the JPYW group compared to the control group.ConclusionOur findings suggest that JPYW extends the lifespan of C. elegans and exerts antiaging effects by increasing the activity of an antioxidant enzyme (SOD) and by regulating the expression of aging-related genes. This study not only indicates that this Chinese compound exerts antiaging effects by activating and repressing target genes but also provides a proven methodology for studying the biological mechanisms of TCMs.

show abstract

“…In modern times, an increasing number of age-related diseases, such as chronic degenerative diseases and other aging-related dysfunctions, have threatened human health (Gladyshev and Gladyshev 2016; Krut’ko et al 2018). Contrary to mainstream modern medicine, TCM aims to interfere with the aging process as early as possible, thus preventing and delaying the occurrence and development of age-related diseases; this approach has begun to attract increasing attention from researchers (Liang and Yin 2010; Chen 2015).…”

Section: Discussionmentioning

confidence: 99%

Liangyi Gao extends lifespan and exerts an antiaging effect in Caenorhabditis elegans by modulating DAF-16/FOXO

et al. 2019

View full text Add to dashboard Cite

Liangyi Gao (LYG), a traditional Chinese medicine, is composed of Ginseng and Radix Rehmanniae Preparata, both of which have been shown to have antiaging properties. In Eastern countries, LYG is used to delay functional declines related to aging and has an obvious antiaging effect in clinical practice. However, little data from evidence-based medicine is available regarding whether LYG is beneficial overall, particularly with respect to lifespan, and how LYG functions. To address these issues, Caenorhabditis elegans, a useful organism for such studies, was employed to explore the antiaging effect and mechanism of LYG in this study. The results showed that LYG could obviously extend lifespan and slow agingrelated declines in N2 wild-type C. elegans. To further characterize these antiaging effects and stress resistance, reproductive tests and other aging-related tests were performed. We found that LYG enhanced resistance against oxidative and thermal stress, reproduction, pharynx pumping, motility and growth in N2

show abstract

Natural aging as as a sequential poly-systemic syndrome

Cited by 14 publications

References 48 publications

The Impact of the Otago Exercise Program on Frailty and Empowerment in Older Nursing Home Residents: A Randomized Controlled Trial

The Impact of the Otago Exercise Program on Frailty and Empowerment in Older Nursing Home Residents: A Randomized Controlled Trial

Antiaging effect of a Jianpi-yangwei formula in Caenorhabditis elegans

Liangyi Gao extends lifespan and exerts an antiaging effect in Caenorhabditis elegans by modulating DAF-16/FOXO

Contact Info

Product

Resources

About