Natriuretic Peptides: Physiologic and Analytic Considerations

Omland, Torbjørn; Hagve, Tor‐Arne

doi:10.1016/j.hfc.2009.04.005

Cited by 49 publications

(41 citation statements)

References 122 publications

(116 reference statements)

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“…It can inhibit the renin-angiotensinaldosterone system and the sympathetic nervous system (7,8), thus decreasing in systemic vascular resistance and cardiac preload and afterload by venous and arterial vasodilation and prevent myocardial remodeling and fibrosis, which results in increasing in cardiac output (10,11).…”

Section: Discussionmentioning

confidence: 99%

“…With the in-depth study of the pathogenesis of heart failure in recent years, the functions of BNP have been further researched that not only does it have effects of diuretic and natriuretic, but it also can prevent myocardial remodeling and fibrosis through the side secretory pathway and inhibit the activation of renin-angiotensin-aldosterone system (RAAS) which can reduce both heart and renal function (7,8).…”

Section: Introductionmentioning

confidence: 99%

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Continuous administration of recombinant human B-type natriuretic peptide can improve heart and renal function in patients after cardiopulmonary bypass surgery

Xiao

et al. 2017

J. Thorac. Dis.

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Background: Any cardiac surgery under cardiopulmonary bypass (CPB) will induce ischemia-reperfusion injury and systematic inflammatory response, which may lead to exacerbation. Conventional therapy strategy is to use inotropes, diuretics and vasodilator drugs, yet, the therapeutic effects of which need to be improved. Recombinant human B-type natriuretic peptide (rhBNP) has been shown to be efficacious in the treatment of acute decompensated heart failure and acute myocardial infarction. However, the effects of rhBNP on patients carried out CPB surgery is unknown. Methods: We retrospect 357 patients carried out CPB surgery between Jan 1st 2014 and Dec 31st 2015 of our department. And according the use of rhBNP, these patients were divided into two groups: rhBNP group and control group. Patients in rhBNP group were received continuous intravenous rhBNP (0.0075-0.01 μg/kg/min) in 6 hours after CPB surgery, for a period of 72 h. Hemodynamic parameters were measured immediately after CPB surgery, and then at 2, 4, 8, 12 and 24 h after surgery. Blood samples were obtained immediately after surgery and thereafter once a day at 6:00 AM within the first 3 days after surgery. The daily urine volume as well as the time of tracheal intubation, ICU stay and chest drainage were also recorded.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Continuous administration of recombinant human B-type natriuretic peptide can improve heart and renal function in patients after cardiopulmonary bypass surgery

Xiao

et al. 2017

J. Thorac. Dis.

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“…Fakat aynı zamanda kardiyak aritmiler, ventriküler hipertrofi, miyokard iskemisi, pulmoner emboli, akut ve kronik kor pulmonale, böbrek yetmezliği, anemi, hipertiroidizm ve sepsis gibi hastalık durumlarında da yükselebilir (20). Graves hastalığı tanısı konmuş hastalarla yapılan bir çalışmada kontrol altındaki hipertiroidi hastalarında da serum NTproBNP düzeyinin yükseldiği saptanmıştir.…”

Section: Discussionunclassified

Tiroid Fonksiyon Bozukluğu Bulunan Hastalarda Erken Dönem Kardiyak Disfonksiyonu Belirlemede N-Terminal Pro-B-Tip Natriüretik Peptid

Ulusoy¹,

Gerek²,

Yiğit³

et al. 2013

haseki

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ÖzetAmaç:Bu çalışmanın amacı hipotiroidi ve hipertiroidi tanısı almış, ekokardiyografik ve klinik olarak herhangi bir kardiyak problemi bulunmayan hastalarda NT-proBNP düzeyinin erken dönem kardiyak disfonksiyonunun belirteci olarak kullanımını araştırmaktır. Yöntem: Hastanemizin İç Hastalıkları polikliniklerine başvuran tiroid hastalığı konmuş 13'ü erkek, 40'ı kadın toplam 53 hasta ile 40 sağlıklı kontrol çalışmaya dahil edildi. Çalışmaya alınan hastaların daha öncesine ait bilinen bir hastalık öyküsü yoktu ve yeni tanı almış aşikar hipotiroidi ve hipertiroidi hastalarıydı. Hasta ve kontrol gruplarının kan örneklerinde rutin biyokimyasal parametrelere, tiroid fonksiyon testlerine ve NT-proBNP düzeylerine bakıldı, elektrokardiyogram çekildi ve ekokardiyografi yapıldı. Bulgular: Çalışmaya alınan hastaların 28'inde hipotiroidi, 25'inde hipertiroidi mevcuttu. Hipotiroid grubun yaş ortalaması daha yüksekti. Hipertiroidi ve hipotiroidili hasta grubunda NTproBNP ortalaması kontrol grubuna göre anlamlı derecede yüksekti (p=0.019). Bu iki hasta grubu ayrı ayrı kontrol grubu ile karşılaştırıldığında NT-proBNP düzeyi hipotiroidili (p=0.0096) ve hipertiroidili (p=0.0415) hastalarda kontrol grubuna göre anlamlı olarak yüksek bulundu. Sonuç:Artmış NT-proBNP düzeyi kalp yetersizliği ve koroner arter hastalığında kötü prognozu gösteren önemli bir belirteçtir. Bu nedenle artmış NT-proBNP düzeyi aşikar hipotiroidi ve hipertiroidisi olan hastalarda erken dönem kardiyak disfonksiyonu belirlemede değerli bir belirteç olabilir. Abs tractAim: The aim of this study was to investigate N-terminal probrain natriuretic peptide (NT-proBNP) as a marker of early cardiac dysfunction in patients with hypothyroidism or hyperthyroidism without any clinical and echocardiographic cardiac problem. Methods:A total of 53 patients (13 male and 40 female), who were newly diagnosed with thyroid disease and 40 healthy controls who attended our internal medicine outpatient clinic, were included in the study. The patients had no history of any disease and, all of them were with newly diagnosed overt hypothyroidism or hyperthyroidism. Routine biochemical tests, and thyroid function tests were done and NT-proBNP levels were measured. Electrocardiograms and echocardiograms were performed. Results: There were 28 patients with hypothyroidsm and 25 patients with hyperthyroidism in the study group. The mean age of hypothyroidism group was higher than that of hyperthyroidism group. The mean NT-proBNP levels were significantly higher in the patient group when compared to the control group (p=0.019). When the two groups of patients were compared with the control group separately, the level of NT-proBNP was significantly higher in hypothyroidism group (p=0.0096) and hyperthyroidism group (p=0.0415). Conclusion: Elevated NT-proBNP levels are an important marker that suggests worse prognosis in heart failure and coronary artery disease. Elevated serum NT-proBNP levels might be a valuable marker to detect early cardiac dysfunction in patients with overt hypothyroidism ...

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“…This peptide is in turn cleaved in varying amounts by an endoprotease, furin, to yield the biologically active, 32-amino acid BNP and a biologically inert, 76-amino acid NT-proBNP ( Fig. 1) [5].…”

Section: Introductionmentioning

confidence: 99%

“…The natriuretic peptide C receptor (NPR-C) binds BNP, acting as a clearance receptor and may also play a role in the mediation of antiproliferative effects exerted on vascular cells by a molecular variant of human ANP. In addition to removal by receptors, BNP is also cleared by neutral endopeptidases (NEP), found in a variety of tissues including endothelial cells, vascular smooth muscle cells, cardiac myocytes, fibroblasts, and even adipose cells, as well as by passive renal excretion [3,5,6].…”

Section: Introductionmentioning

confidence: 99%

Biomarkers in the Management of Heart Failure

Kim

Januzzi

2010

Curr Treat Options Cardio Med

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Biomarkers, especially natriuretic peptides such as B-type natriuretic peptide (BNP) and N-terminal-proBNP (NT-proBNP), are a valuable addition to standard clinical assessment in the diagnosis and prognosis of heart failure (HF). Furthermore, there is an increasing amount of evidence suggesting that natriuretic peptide-guided HF management may improve mortality, morbidity, and cost effectiveness. This work focuses on the use of BNP or NT-proBNP for the outpatient management of patients with chronic HF.

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Natriuretic Peptides: Physiologic and Analytic Considerations

Cited by 49 publications

References 122 publications

Continuous administration of recombinant human B-type natriuretic peptide can improve heart and renal function in patients after cardiopulmonary bypass surgery

Continuous administration of recombinant human B-type natriuretic peptide can improve heart and renal function in patients after cardiopulmonary bypass surgery

Tiroid Fonksiyon Bozukluğu Bulunan Hastalarda Erken Dönem Kardiyak Disfonksiyonu Belirlemede N-Terminal Pro-B-Tip Natriüretik Peptid

Biomarkers in the Management of Heart Failure

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