Natriuretic Peptides as Predictors of Protein-Energy Wasting in Hemodialysis Population

Luce, Mathilde; Bres, Émilie; Pastural, Myriam; Granjon, Samuel; Szelag, Jean Christophe; Laville, Maurice; Arkouche, Walid; Bouchara, Anaïs; Fouque, Denis; Soulage, Christophe O.; Koppe, Laetitia

doi:10.1053/j.jrn.2021.03.002

Cited by 7 publications

(4 citation statements)

References 41 publications

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“…A possible reason for the association between plasma NT-proANP concentration and bodyweight observed in this study could be the loss of lean body mass. Recently, ANP receptors have been found to be expressed in the adipose tissue of humans and mice, and ANP has been identified as a potent lipolytic hormone in human adipocytes (Sengenes et al 2003, Coué & Moro 2016, Luce et al 2022. In addition, ANP has been reported to activate resting energy expenditure by inducing rodent white adipose tissue browning in CKD (Luce et al 2020).…”

Section: Discussionmentioning

confidence: 99%

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Association between glomerular filtration rate and plasma N‐terminal pro‐atrial natriuretic peptide concentration in dogs

Ogawa

Nohara

Hsu

et al. 2023

J of Small Animal Practice

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ObjectivesTo investigate the association between plasma N‐terminal pro‐atrial natriuretic peptide concentration and glomerular filtration rate in dogs.Materials and MethodsDogs were classified into four categories by bodyweight. Dogs were divided into four groups (Groups 1 to 4) based on glomerular filtration rate estimates using plasma iohexol clearance per bodyweight category. Generalised linear models were built to explore the relationship between plasma N‐terminal pro‐atrial natriuretic peptide concentration and glomerular filtration rate and the effect of confounders on plasma N‐terminal pro‐atrial natriuretic peptide concentration.ResultsFifty‐three dogs were included (Group 1, 25; Group 2, seven; Group 3, five; and Group 4, 16). The medians (interquartile range) N‐terminal pro‐atrial natriuretic peptide concentrations for Groups 1 to 4 were 7224 pg/mL (4766 to 10,254 mg/dL), 8958 pg/mL (4935 to 11,271 mg/dL), 9280 pg/mL (9195 to 10,384 mg/dL) and 12,683 pg/mL (9133 to 19,217 mg/dL), respectively. Group 4, estimated to have the highest reduction in glomerular filtration rate, had a higher plasma N‐terminal pro‐atrial natriuretic peptide concentration than Groups 1 to 3. Based on the final generalised linear model, influencing factors for plasma N‐terminal pro‐atrial natriuretic peptide concentration were plasma iohexol clearance (−0.136; 95% confidence interval, −0.227 to −0.046) and bodyweight (−0.058; 95% confidence interval, −0.098 to −0.018).Clinical SignificanceN‐terminal pro‐atrial natriuretic peptide concentration is associated with the glomerular filtration rate.

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Section: Discussionmentioning

confidence: 99%

“…2003, Coué & Moro 2016, Luce et al . 2022). In addition, ANP has been reported to activate resting energy expenditure by inducing rodent white adipose tissue browning in CKD (Luce et al .…”

Section: Discussionmentioning

confidence: 99%

Association between glomerular filtration rate and plasma N‐terminal pro‐atrial natriuretic peptide concentration in dogs

Ogawa

Nohara

Hsu

et al. 2023

J of Small Animal Practice

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show abstract

“…Recent studies have demonstrated a positive 10.3389/fnut.2022.933745 correlation between proBNP and malnutrition (50), and NT-proBNP might be an independent biomarker of PEW, especially in MHD patients (21). The accumulation of NT-proBNP is negatively associated with body fat mass and significantly correlated with the increased incidence of PEW in hemodialysis patients (51). Furthermore, NT-proBNP could predict all-cause mortality in hemodialysis patients, especially coronary heart disease (21).…”

Section: Discussionmentioning

confidence: 99%

An updated clinical prediction model of protein-energy wasting for hemodialysis patients

Chen

Ma²,

Wang³

et al. 2022

Front. Nutr.

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Background and aimProtein-energy wasting (PEW) is critically associated with the reduced quality of life and poor prognosis of hemodialysis patients. However, the diagnosis criteria of PEW are complex, characterized by difficulty in estimating dietary intake and assessing muscle mass loss objectively. We performed a cross-sectional study in hemodialysis patients to propose a novel PEW prediction model.Materials and methodsA total of 380 patients who underwent maintenance hemodialysis were enrolled in this cross-sectional study. The data were analyzed with univariate and multivariable logistic regression to identify influencing factors of PEW. The PEW prediction model was presented as a nomogram by using the results of logistic regression. Furthermore, receiver operating characteristic (ROC) and decision curve analysis (DCA) were used to test the prediction and discrimination ability of the novel model.ResultsBinary logistic regression was used to identify four independent influencing factors, namely, sex (P = 0.03), triglycerides (P = 0.009), vitamin D (P = 0.029), and NT-proBNP (P = 0.029). The nomogram was applied to display the value of each influencing factor contributed to PEW. Then, we built a novel prediction model of PEW (model 3) by combining these four independent variables with part of the International Society of Renal Nutrition and Metabolism (ISRNM) diagnostic criteria including albumin, total cholesterol, and BMI, while the ISRNM diagnostic criteria served as model 1 and model 2. ROC analysis of model 3 showed that the area under the curve was 0.851 (95%CI: 0.799–0.904), and there was no significant difference between model 3 and model 1 or model 2 (all P > 0.05). DCA revealed that the novel prediction model resulted in clinical net benefit as well as the other two models.ConclusionIn this research, we proposed a novel PEW prediction model, which could effectively identify PEW in hemodialysis patients and was more convenient and objective than traditional diagnostic criteria.

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“…Whereas dietary intake of patients was comparable for some parameters and different for others between these 2 large countries, the study emphasizes the overall low dietary energy, protein, calcium, and vitamin C intake of patients requiring hemodialysis. Natriuretic peptides were examined in a group of hemodialysis patients by Luce et al 35 They compared N-terminal pro-B-type natriuretic peptide and atrial natriuretic peptide with bioimpedance spectroscopy in a prospective study. Natriuretic peptides were associated with malnutrition and survival in these patients and deserve further research.…”

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confidence: 99%

Global Kidney Nutrition Care and Health Literacy: Overcoming the Disparities in Renal Nutrition Service Capacity and Education

Moore

Wang

Kalantar‐Zadeh

2022

Journal of Renal Nutrition

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Natriuretic Peptides as Predictors of Protein-Energy Wasting in Hemodialysis Population

Cited by 7 publications

References 41 publications

Association between glomerular filtration rate and plasma N‐terminal pro‐atrial natriuretic peptide concentration in dogs

Association between glomerular filtration rate and plasma N‐terminal pro‐atrial natriuretic peptide concentration in dogs

An updated clinical prediction model of protein-energy wasting for hemodialysis patients

Global Kidney Nutrition Care and Health Literacy: Overcoming the Disparities in Renal Nutrition Service Capacity and Education

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