Natriuretic peptide testing in emergency settings

Ordóñez-Llanos, Jordi; Mercé-Muntañola, J.; Santaló-Bel, Miquel

doi:10.1515/cclm.2008.298

Cited by 4 publications

(2 citation statements)

References 27 publications

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“…In addition to, the left ventricular (LV) systolic dysfunction, plasma BNP levels have been suggested to be significantly associated with diastolic stage (including newer echocardiographic parameters as tissue Doppler imaging and color M-mode propagation velocity) and right ventricular (RV) functions as well (6)(7)(8)(9). Though the relationship between BNP and left and right ventricular functions have been elucidated in patients with systolic heart failure (10), the diagnostic value of BNP in prediction of right and left ventricular systolic/diastolic functions in patients with acute heart failure is not well established and literature data are controversial (11).…”

Section: Introductionmentioning

confidence: 99%

The relationship between B-type natriuretic peptide levels and echocardiographic parameters in patients with heart failure admitted to the emergency department

Karakılıç

Kepez²,

Abalı³

et al. 2010

Anadolu Kardiyol Derg

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Objective: Brain natriuretic peptide (BNP) is a peptide, which has recently been used in the differential diagnosis and follow-up of patients with heart failure. Our aim in the present prospective and diagnostic designed study is to investigate the role of BNP in determining the etiology of dyspnea and to evaluate its relation with newer echocardiographic parameters. Methods: Thirty-four patients presenting to the emergency department with dyspnea and fulfilling the Framingham criteria for heart failure were included in the study. Blood samples were obtained in the first hour of presentation for measurement of BNP levels from all patients. Detailed transthoracic two-dimensional, Doppler and tissue Doppler echocardiographic studies were then performed within 24 hours of presentation. Statistical analyses were performed using Student's t-test for independent samples, Mann Whitney U test and Pearson or Spearman correlation tests. Results: Plasma BNP levels were found to be significantly correlated with left ventricular end-systolic and end-diastolic diameter, left atrial diameter and the degree of mitral insufficiency (r=0. 46, p=0.007; r=0.39, p=0.02; r=0.32, p=0.065; r=0.50, p=0.014, respectively). A significant inverse correlation was observed between plasma BNP levels and left ventricular ejection fraction (r=-0.5, p=0.003). When the patients were grouped according to their BNP levels, the mean ejection fraction of the group with BNP levels below median (578 pg/l) was 60.65±13.84%, whereas the mean ejection fraction of the group with BNP levels of 578 pg/l or above (BNP 2) was 49.41±15.26% (p=0.027). Out of parameters reflecting left ventricular diastolic functions, only transmitral Epeak/Apeak ratio was found to be significantly associated with BNP levels (r=0.4, p=0.05). Tissue Doppler study revealed significant correlations between BNP levels and right ventricular basal and midsystolic velocities (r=-0.507, p=0.008; r=-0.562, p=0.005, respectively) while none of the left ventricular tissue velocities displayed significant correlation with BNP values. Conclusion: Plasma BNP levels are found to be significantly associated with conventional echocardiographic parameters reflecting left ventricular systolic and diastolic functions and tissue Doppler velocities reflecting right ventricular functions. Our findings are in agreement with the notion that plasma BNP levels are beneficial in the differential diagnosis of patients admitted to emergency service with acute dyspnea. (Anadolu Kardiyol Derg 2010; 10: 143-9) Key words: Natriuretic peptide, heart failure, echocardiography, color Doppler echocardiography, tissue Doppler echocardiography, stroke volume, diagnostic value of tests ÖZET Amaç: Beyin natriüretik peptit (BNP) kalp yetersizliği olan hastaların ayırıcı tanısında ve takibinde kullanılan bir peptitdir. Prospektif ve diyagnostik dizaynı olan bu çalışmada amacımız, BNP'nin nefes darlığının etiyolojisini belirlemedeki rolü ve yeni ekokardiyografik parametrelerle ilişkisini araştırmaktır. Yöntemler: Acil servi...

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Section: Introductionmentioning

confidence: 99%

The relationship between B-type natriuretic peptide levels and echocardiographic parameters in patients with heart failure admitted to the emergency department

Karakılıç

Kepez²,

Abalı³

et al. 2010

Anadolu Kardiyol Derg

View full text Add to dashboard Cite

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“…7 The clinical utility of BNP as a HF biomarker that accurately reflects a patient's symptoms of dyspnea is widely accepted, with sensitivity of 90%, specificity of 76%, and accuracy of 84% (for differentiating HF from other causes of dyspnea). 7 The clinical utility of BNP as a HF biomarker that accurately reflects a patient's symptoms of dyspnea is widely accepted, with sensitivity of 90%, specificity of 76%, and accuracy of 84% (for differentiating HF from other causes of dyspnea).…”

Section: Hf Screening Tool Developmentmentioning

confidence: 99%

Evaluation of an Inpatient Heart Failure Screening Tool

Nadeau

Gallo

Fields³

2014

Journal of Nursing Care Quality

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Heart failure is increasing in incidence, prevalence, and mortality. The purpose of this study was to test the predictive accuracy of a screening tool to identify inpatients with heart failure. The tool demonstrated statistical significance for predictability, with 68.3% sensitivity, 86% specificity, and overall accuracy of 77.5%. The tool facilitated heart failure screening and subsequent implementation of evidence-based therapies.

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