Natriuretic Peptide Resistance of Mesenteric Arteries in Spontaneous Hypertensive Rat Is Alleviated by Exercise

Abstract

Proximal resistance vessels, such as the mesenteric arteries, contribute substantially to the peripheral resistance. The reactivity of resistance vessels to vasoactive substance like natriuretic peptides plays an important role in the regulation of blood pressure. In current study, we investigated the reactivity of mesenteric arteries to atrial natriuretic peptide (ANP), a well known vasodilating factor, in spontaneously hypertensive rats (SHR), as well as the effects of exercise training on it. As a result, ANP-induced vasorelaxation was attenuated in SHR with significantly increased phosphodiesterase type 5 (PDE5), and decreased cGMP/ANP ratio, compared with WKY rats as control. Intriguingly, the decreased reactivity to ANP in SHR was markedly reversed by exercise training. In addition, ANP resistance of in vitro mesenteric arteries was diminished by sildenafil a potent selective inhibitor of PDE5. In conclusion, ANP resistance occurs in resistance vessels of SHR, suggesting predisposition to hypertension, which can be reversed by exercise.

Saffron (Crocus sativus L.) in combination with resistance training reduced blood pressure in the elderly hypertensive men: A randomized controlled trial

“…Apart from the rarity of studies on the effect of RT on ANP levels in hypertensive patients, Yu et al showed that 12 weeks of swimming without load reversed the vascular resistance to ANP in SHR and pronounced the vasorelaxant effects of ANP. DBP, SBP and MAP also showed significant reductions 50 . In the only study of the effect of saffron on ANP, the authors found that crocetin in hypertrophy induced by blocking the MEK‐ERK1/2 signalling pathway prevented ANP from increasing and has a protective impact on the progression of cardiac failure 51 .…”

Cardiovascular Effects Induced by Fruit Peels from Passiflora edulis in Hypertensive Rats and Fingerprint Analysis by HPLC-ESI-MSn spectrometry

“…Next, a spontaneously hypertensive rat (SHR) model was used to assess the chronic effect of PFHE on the cardiovascular system. This in vivo model is considered similar to the essential pathophysiology of hypertension [21].…”

Soluble guanylate cyclase chronic stimulation effects on cardiovascular reactivity in cafeteria diet-induced rat model of metabolic syndrome

“…In addition, this is in line with the lack of difference between groups concerning intracellular cGMP content in thoracic aorta observed in our experimental conditions. It is widely documented that resistant arteries play an important role in the regulation of blood pressure in SHR (Yu et al, 2016) and are less dependent on NO than thoracic aorta (Lyoussi et al, 2018). A complementary study of the vascular reactivity in resistance arteries would therefore be interesting to better assess the effects of CD and BAY 41-2272 treatment.…”