Native valve infective endocarditis due to Micrococcus luteus in a non-Hodgkin’s lymphoma patient

Ianniello, Nicole; Andrade, Diana C.; Ivancic, Stipe; Eckardt, Paula; Ramirez, Juan C. Lemos

doi:10.1016/j.idcr.2019.e00657

Cited by 29 publications

(22 citation statements)

References 9 publications

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“…The widespread occurrence, and also high variability in terms of copy number and composition of the potential VF and AR genes among M. luteus strains, emphasized their importance in the pathogenic features. It has been reported that M. luteus could cause severe infections in immunocompromised populations, including peritonitis, brain abscesses, pneumonia, septic arthritis and so on [21][22][23][24]. The presence of several virulence determinants and antibiotic-resistance genes in M. luteus should be paid attention to, the pro les of which will provide guidance for the future treatment of M. luteus infections.…”

Section: Potential Virulence Factors and Antibiotic Resistance Genes mentioning

confidence: 99%

“…The rst documented disease caused by M. luteus was septic shock in 1978 [20]. In fact, M. luteus was once considered to be a non-pathogenic saprophyte or pure contaminant from skin and mucous membranes, but it is now proved to cause bacteremia, pneumonia, endocarditis, lymphoma, septic arthritis and any other diseases [21][22][23][24]. Therefore, as an important material of biotechnological interest and an emerging nosocomial pathogen, M. luteus has received increasing attention in recent years.…”

Section: Introductionmentioning

confidence: 99%

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Comparative Genomics Reveals Broad Genetic Diversity, Extensive Recombination and Nascent Ecological Adaptation in Micrococcus luteus

Sun

Rong

et al. 2020

Preprint

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Background: Micrococcus luteus is a group of actinobacteria that is widely used in biotechnology and is being thought as an emerging nosocomial pathogen. With one of the smallest genomes of free-living actinobacteria, it is found in a wide range of environments, but intraspecies genetic diversity and adaptation strategies to various environments remain unclear. Here, comparative genomics, phylogenomics, and genome-wide association studies (GWAS) were used to investigate the genomic diversity, evolutionary history, and the potential ecological differentiation of the species.Results: High-quality genomes of 66 M. luteus strains were downloaded from the NCBI GenBank database and core and pangenome analysis revealed a considerable intraspecies heterogeneity. Phylogenomic analysis, gene content comparison, and average nucleotide identity calculation consistently indicated that the species has diverged into three well-differentiated clades. Population structure analysis revealed four admixed ancestral subpopulations, with three of them corresponding to the three clades, respectively, and the fourth corresponding to an unknown ancestor or the fourth, yet unsampled, clade. Reconstruction of gene gain/loss events along the evolutionary history revealed both early events that contributed to the inter-clade divergence and recent events leading to the intra-clade diversity. We also found convincing evidence that recombination has played a key role of the evolutionary process of the species, with upto two-thirds of the core genes have been affected by recombination. Furthermore, distribution of mammal-associated strains (including pathogens) on the phylogenetic tree strongly suggested that the last common ancestor had a free-living lifestyle, and a few recently diverged lineages have developed a mammal-associated lifestyle separately. Consistently, genome-wide association studies revealed that mammal-associated strains from different lineages shared genes functionally relevant to the host-associated lifestyle, indicating a recent ecological adaption to the new host-associated habitats.Conclusions: These results revealed high intraspecies genomic diversity of M. luteus and highlighted that gene gain/loss events and extensive recombination events played key roles in the genome evolution. Our study also indicated that, as a free-living species, some lineages have recently developed or are developing a mammal-associated lifestyle. This study provides insights into the mechanisms that drive the genome evolution and adaption to various environments of a bacterial species.

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Section: Potential Virulence Factors and Antibiotic Resistance Genes mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Comparative Genomics Reveals Broad Genetic Diversity, Extensive Recombination and Nascent Ecological Adaptation in Micrococcus luteus

Sun

Rong

et al. 2020

Preprint

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“…Coagulase-negative staphylococci and Micrococcus spp. are related to opportunistic infections, including community-acquired ones in immunocompromised subjects ( Seng et al 2017 ; Shi et al 2017 ; Ianiello et al 2019 ). In addition, strains B1N2 and DM4S1 were identified as S. aureus , a well-known pathogen responsible for a broad range of infections but particularly famous for causing food poisoning ( Sergelidis and Angelidis 2017 ).…”

Section: Discussionmentioning

confidence: 99%

Multidrug-resistant Opportunistic and Pathogenic Bacteria Contaminate Algerian Banknotes Currency

Djouadi

Guezlane-Tebibel

Mansouri

et al. 2020

Polish Journal of Microbiology

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Currency is one of the most exchanged items in human communities as it is used daily in exchange for goods and services. It is handled by persons with different hygiene standards and can transit in different environments. Hence, money can constitute a reservoir for different types of human pathogens. This study aimed to evaluate the potential of Algerian banknotes to shelter opportunistic pathogenic and multiresistant bacteria. To that end, 200 circulating notes of four different denominations were collected from various places and analyzed for their bacterial loads and contents. Besides, predominant strains were identified and characterized by biochemical and molecular methods, and their resistance profiles against 34 antibiotics were determined. Our results indicated that 100% of the studied banknotes were contaminated with bacteria. The total bacterial concentrations were relatively high, and different bacterial groups were grown, showing important diversity. In total, 48 predominant strains were identified as belonging to 17 genera. Staphylococcus and Micrococcus were the most prevalent genera, followed by Bacillus, Pseudomonas, and Acinetobacter. Antibiotic susceptibility testing showed that all the isolates harbored resistance to at least two molecules, and worrying resistance levels were observed. These findings prove that Algerian currency harbors opportunistic multiresistant bacteria and could potentially act as a vehicle for the spread of bacterial diseases and as a reservoir for antibiotic resistance genes among the community. Therefore, no cash payment systems should be developed and generalized to minimize cash handling and subsequent potential health risks.

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“…Micrococcus luteus, the type species of the genus Micrococcus (family Micrococcaceae, order Micrococcales), is a high GC Gram-positive cocci of the phylum Actinobacteria [1]. M. luteus is known as an opportunistic pathogen for nosocomial infections [2], and has been proved to be able to cause bacteremia, pneumonia, endocarditis, lymphoma, septic arthritis and many other diseases [3][4][5]. Besides as a pathogen, M. luteus is ubiquitously distributed in variety of habitats, including soil, air, marine, plant and the human body [6], indicating that this species has been well adapted to various environments.…”

Section: Introductionmentioning

confidence: 99%

Comparative Genomics Reveals Broad Genetic Diversity, Extensive Recombination and Nascent Ecological Adaptation in Micrococcus luteus

Sun

Rong

et al. 2021

Preprint

View full text Add to dashboard Cite

Background: Micrococcus luteus is a group of actinobacteria that is widely used in biotechnology and is being thought as an emerging nosocomial pathogen. With one of the smallest genomes of free-living actinobacteria, it is found in a wide range of environments, but intraspecies genetic diversity and adaptation strategies to various environments remain unclear. Here, comparative genomics, phylogenomics, and genome-wide association studies were used to investigate the genomic diversity, evolutionary history, and the potential ecological differentiation of the species.Results: High-quality genomes of 66 M. luteus strains were downloaded from the NCBI GenBank database and core and pan-genome analysis revealed a considerable intraspecies heterogeneity. Phylogenomic analysis, gene content comparison, and average nucleotide identity calculation consistently indicated that the species has diverged into three well-differentiated clades. Population structure analysis further suggested the existence of an unknown ancestor or the fourth, yet unsampled, clade. Reconstruction of gene gain/loss events along the evolutionary history revealed both early events that contributed to the inter-clade divergence and recent events leading to the intra-clade diversity. We also found convincing evidence that recombination has played a key role of the evolutionary process of the species, with upto two-thirds of the core genes have been affected by recombination. Furthermore, distribution of mammal-associated strains (including pathogens) on the phylogenetic tree suggested that the last common ancestor had a free-living lifestyle, and a few recently diverged lineages have developed a mammal-associated lifestyle separately. Consistently, genome-wide association analysis revealed that mammal-associated strains from different lineages shared genes functionally relevant to the host-associated lifestyle, indicating a recent ecological adaption to the new host-associated habitats.Conclusions: These results revealed high intraspecies genomic diversity of M. luteus and highlighted that gene gain/loss events and extensive recombination events played key roles in the genome evolution. Our study also indicated that, as a free-living species, some lineages have recently developed or are developing a mammal-associated lifestyle. This study provides insights into the mechanisms that drive the genome evolution and adaption to various environments of a bacterial species.

show abstract

Native valve infective endocarditis due to Micrococcus luteus in a non-Hodgkin’s lymphoma patient

Cited by 29 publications

References 9 publications

Comparative Genomics Reveals Broad Genetic Diversity, Extensive Recombination and Nascent Ecological Adaptation in Micrococcus luteus

Comparative Genomics Reveals Broad Genetic Diversity, Extensive Recombination and Nascent Ecological Adaptation in Micrococcus luteus

Multidrug-resistant Opportunistic and Pathogenic Bacteria Contaminate Algerian Banknotes Currency

Comparative Genomics Reveals Broad Genetic Diversity, Extensive Recombination and Nascent Ecological Adaptation in Micrococcus luteus

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