Native valve endocarditis complicated by abscess formation caused by Rothia mucilaginosa

Haddad, Sara; Saade, Yves-Assad; Ramlawi, Basel; Kreidieh, Bahij; Gilbert, Brett; Rao, S Suryaprakasa

doi:10.1016/j.idcr.2021.e01348

Cited by 5 publications

(1 citation statement)

References 16 publications

(32 reference statements)

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“…infections rarely occur in healthy humans and are mostly reported in immunocompromised hosts [12][13][14][15][16]. Invasive Rothia species infections have been reported in immunocompromised patients with endocarditis [17], meningitis [18,19], pneumonia [20], endophthalmitis [21,22], peritonitis [23,24] and prosthetic device infections [25][26][27][28][29].…”

Section: Discussionmentioning

confidence: 99%

Native Joint Septic Arthritis Due to Rothia mucilaginosa: A Case Report and Literature Review

2023

Infect Dis Diag Treat

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Rothia spp. are gram-positive bacteria that are part of the normal human oral and gut microbiome. They mainly cause opportunistic infections in immunocompromised hosts and are associated with periodontal disease. Here, we present a rare case of septic arthritis of a native knee due to Rothia mucilaginosa in a 66-year-old, immunocompetent, male patient with osteoarthritis of both knees. Intra-articular corticosteroid injection was identified as most likely source of infection. We discuss the increase of iatrogenic joint infections caused by intra-articular injections or surgical procedures and identify the association of Rothia mucilaginosa joint infections with intra-articular corticosteroid injections.

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Section: Discussionmentioning

confidence: 99%

Native Joint Septic Arthritis Due to Rothia mucilaginosa: A Case Report and Literature Review

2023

Infect Dis Diag Treat

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Influence of dental status on postoperative complications in major visceral surgical and organ transplantation procedures—the bellydent retrospective observational study

Spitzner,

Mieth,

Langan

et al. 2024

Langenbecks Arch Surg

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Purpose The significance of dental status and oral hygiene on a range of medical conditions is well-recognised. However, the correlation between periodontitis, oral bacterial dysbiosis and visceral surgical outcomes is less well established. To this end, we study sought to determine the influence of dental health and oral hygiene on the rates of postoperative complications following major visceral and transplant surgery in an exploratory, single-center, retrospective, non-interventional study. Methods Our retrospective non-interventional study was conducted at the Department of General, Visceral, and Transplant Surgery, University Hospital Heidelberg, Germany. Patients operated on between January 2018 and December 2019 were retrospectively enrolled in the study based on inclusion (minimum age of 18 years, surgery at our Department, intensive care / IMC treatment after major surgery, availability of patient-specific preoperative dental status assessment, documentation of postoperative complications) and exclusion criteria (minor patients or legally incapacitated patients, lack of intensive care or intermediate care (IMC) monitoring, incomplete documentation of preoperative dental status, intestinal surgery with potential intraoperative contamination of the site by intestinal microbes, pre-existing preoperative infection, absence of data regarding the primary endpoints of the study). The primary study endpoint was the incidence of postoperative complications. Secondary study endpoints were: 30-day mortality, length of hospital stay, duration of intensive care stay, Incidence of infectious complications, the microbial spectrum of infectious complication. A bacteriology examination was added whenever possible (if and only if the examination was safe for the patient)for infectious complications. Results The final patient cohort consisted of 417 patients. While dental status did not show an influence (p = 0.73) on postoperative complications, BMI (p = 0.035), age (p = 0.049) and quick (p = 0.033) were shown to be significant prognostic factors. There was significant association between oral health and the rate of infectious complications for all surgical procedures (p = 0.034), excluding transplant surgery. However, this did not result in increased 30-day mortality rates, prolonged intensive care unit treatment or an increase in the length of hospital stay (LOS) for the cohort as a whole. In contrast there was a significant correlation between the presence of oral pathogens and postoperative complications for a group as a whole (p < 0.001) and the visceral surgery subgroup (p < 0.001). Whilst this was not the case in the cohort who underwent transplant surgery, there was a correlation between oral health and LOS in this subgroup (p = 0.040). Bacterial swabs supports the link between poor oral health and infectious morbidity. Conclusions Dental status was a significant predictor of postoperative infectious complications in this visceral surgery cohort. This study highlights the importance preoperative dental assessment and treatment prior to major surgery, particularly in the case of elective surgical procedures. Further research is required to determine the effect of oral health on surgical outcomes in order to inform future practice. Trial registration Trial registered under the ethics-number S-082/2022 (Ethic Committee of the University Heidelberg).

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The gut microbiome across the cardiovascular risk spectrum

Prins,

Collij,

Groot

et al. 2023

European Journal of Preventive Cardiology

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Aims Despite treatment advancements, cardiovascular disease remains a leading cause of death worldwide. Identifying new targets is crucial for enhancing preventive and therapeutic strategies. The gut microbiome has been associated with coronary artery disease (CAD), however our understanding of specific changes during CAD development remains limited. We aimed to investigate microbiome changes in participants without clinically manifest CAD with different cardiovascular risk levels and in patients with ST-elevation myocardial infarction (STEMI). Methods and results In this cross-sectional study, we characterized the gut microbiome using metagenomics of 411 faecal samples from individuals with low (n = 130), intermediate (n = 130), and high (n = 125) cardiovascular risk based on the Framingham score, and STEMI patients (n = 26). We analysed diversity, and differential abundance of species and functional pathways while accounting for confounders including medication and technical covariates. Collinsella stercoris, Flavonifractor plautii, and Ruthenibacterium lactatiformans showed increased abundances with cardiovascular risk, while Streptococcus thermophilus was negatively associated. Differential abundance analysis revealed eight species and 49 predicted metabolic pathways that were differently abundant among the groups. In the gut microbiome of STEMI patients, there was a depletion of pathways linked to vitamin, lipid, and amino acid biosynthesis. Conclusion We identified four microbial species showing a gradual trend in abundance from low-risk individuals to those with STEMI, and observed differential abundant species and pathways in STEMI patients compared to those without clinically manifest CAD. Further investigation is warranted to gain deeper understanding of their precise role in CAD progression and potential implications, with the ultimate goal of identifying novel therapeutic targets.

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Native valve endocarditis complicated by abscess formation caused by Rothia mucilaginosa

Cited by 5 publications

References 16 publications

Native Joint Septic Arthritis Due to Rothia mucilaginosa: A Case Report and Literature Review

Native Joint Septic Arthritis Due to Rothia mucilaginosa: A Case Report and Literature Review

Influence of dental status on postoperative complications in major visceral surgical and organ transplantation procedures—the bellydent retrospective observational study

The gut microbiome across the cardiovascular risk spectrum

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