Native nephrectomy in pediatric transplantation – Less is more!

Fraser, Nia; Lyon, Paul; Williams, A.R.; Christian, Martin; Shenoy, Manoj

doi:10.1016/j.jpurol.2011.12.008

Cited by 29 publications

(30 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Nephrectomy of the native kidney or native ureter ligation as a “functional” nephrectomy was performed in case of uncontrollable renovascular hypertension, massive proteinuria, infections, huge polycystic kidneys, and malignant lesions . When nephrectomy was essential, the distal part of the native ureter was left intact and could be used if necessary (i.e., graft ureter too short).…”

Section: Methodsmentioning

confidence: 99%

Urological complications following kidney transplantation in pediatric age: A single‐center experience

Rossi

Torino

Nappo

et al. 2016

Pediatric Transplantation

View full text Add to dashboard Cite

Surgical complications during kidney transplantation can seriously affect renal outcomes. We assess occurrence, risk factors, and results of all urological complications in a series of renal transplants in a single center. Children who underwent renal transplant between January 2008 and December 2014 were retrospectively evaluated. Postoperative urological complications were reviewed. Demographic details, cause of ESRD, donor type, and surgical procedures at transplant were analyzed. For statistical analysis, the chi-square test or Fisher's exact test were used as appropriate. One hundred and twenty-one kidney transplants were performed in 117 children (median age 12 yr). Sixty-two of 121 (53%) had an underlying urological malformation. At a median follow-up of three yr, 28 urological complications were recorded (23%): 12 lymphocele (10%), 10 ureteral obstruction (8%), three urinary leakage (2.5%), two symptomatic VUR (1.7%), and one hydropyonephrosis. When lymphocele was excluded, the complication incidence rate dropped to 13%. Ureteral obstruction mostly occurred late after transplant (more than six months). Presence of urological malformation was the only factor related to increased occurrence of urological complication (p = 0.007) and, in particular, ureteral obstruction (p = 0.018). Children with urological malformations presented a statistically significant risk of developing urological complications after kidney transplantation, ureteral obstruction being the most common complication.

show abstract

Section: Methodsmentioning

confidence: 99%

Urological complications following kidney transplantation in pediatric age: A single‐center experience

Rossi

Torino

Nappo

et al. 2016

Pediatric Transplantation

View full text Add to dashboard Cite

show abstract

“…According to Fraser et al' study, indications for native nephrectomy prior to renal transplantation have included the following causes: chronic renal parenchymal infection with high grade VUR, hydronephrosis or calculi, glomerulopathy with heavy proteinuria, uncontrollable hypertension, symptoms arising from large polycystic kidneys, acquired renal cystic disease, and malignancy (12). We performed two native nephroureterectomies with concerns of possible recurrent urologic infection.…”

Section: Discussionmentioning

confidence: 99%

Our Initial Experiences and Outcomes of Pediatric Kidney Transplantations / Cocuk Hastalara Yaptigimiz Bobrek Nakilleri ile Ilgili Ilk Deneyimlerimiz ve Sonuclarimiz

Pişkin¹,

Ünal²,

Tabel³

2016

J Turgut Ozal Med Cent

View full text Add to dashboard Cite

Objectives: Kidney transplantation is the best treatment method associated with improved quality of life and better survival for both adult and pediatric patients with end stage renal disease. We have performed a total of 117 kidney transplantations from living or deceased donors between November 2010 and May 2014. Thirteen of these were pediatric kidney transplantations. Here, we present our initial experiences and outcomes of these pediatric kidney transplantations. Materials and Methods: One of the pediatric recipients who underwent en bloc and dualkidney transplantation from a deceased donor was excluded from this study. This recipient was a 40-month-old patient whose donor was an eleven-month-infant. Her allograft kidneys were explanted because of vascular thrombosis on the first postoperative day. We collected and retrospectively analyzed the data of the other twelve pediatric transplantation recipients and their donors. Seven of these kidney transplantations were from deceased donors and five from living donors. All recipients and the five living donors underwent a thorough examination and their clinical history was studied with in detail. Results: Deceased to living donor ratio was 7:5, respectively. The mean follow up period was 31.8 (1-42) months from living donors group and 16.8 (2-28) months from deceased donors group, respectively. Graft survival was 100% during this period. No kidney was lost from rejection, technical causes, infection or recurrent diseases. The living donors are also still alive without any problems. Conclusion: For pediatric end stage renal disease patients, kidney transplantation should be done from deceased or living donors as soon as possible.

show abstract

“…Occasionally, native nephrectomies are performed prior to or at the time of transplant to help with management of hypertension (22). However, this is becoming an uncommon practice because recent data suggest that the benefit is limited (23).…”

Section: Etiology Of Hypertensionmentioning

confidence: 99%

Hypertension in the Pediatric Kidney Transplant Recipient

Charnaya

Moudgil

2017

Front. Pediatr.

View full text Add to dashboard Cite

Hypertension after kidney transplant is a frequent occurrence in pediatric patients. It is a risk factor for graft loss and contributes to the significant burden of cardiovascular disease (CVD) in this population. The etiology of posttransplant hypertension is multifactorial including donor factors, recipient factors, medications, and lifestyle factors similar to those prevalent in the general population. Ambulatory blood pressure monitoring has emerged as the most reliable method for measuring hypertension in pediatric transplant recipients, and many consider it to be essential in the care of these patients. Recent technological advances including measurement of carotid intima-media thickness, pulse wave velocity, and myocardial strain using specked echocardiography and cardiac magnetic resonance imaging have improved our ability to assess CVD burden. Since hypertension remains underrecognized and inadequately treated, an early diagnosis and an appropriate control should be the focus of therapy to help improve patient and graft survival.

show abstract

Native nephrectomy in pediatric transplantation – Less is more!

Abstract: When malignancies were excluded, PTNN was performed in a minority (8.4%) of children, mainly for proteinuria. This adds great advantage by reducing morbidity. Resulting graft function seems favorable.

Cited by 29 publications

References 19 publications

Urological complications following kidney transplantation in pediatric age: A single‐center experience

Urological complications following kidney transplantation in pediatric age: A single‐center experience

Our Initial Experiences and Outcomes of Pediatric Kidney Transplantations / Cocuk Hastalara Yaptigimiz Bobrek Nakilleri ile Ilgili Ilk Deneyimlerimiz ve Sonuclarimiz

Hypertension in the Pediatric Kidney Transplant Recipient

Contact Info

Product

Resources

About