Native ion mobility‐mass spectrometry reveals the binding mechanisms of anti‐amyloid therapeutic antibodies
Yilin Han,
Alec A. Desai,
Jennifer M. Zupancic
et al.
Abstract:One of the most important attributes of anti‐amyloid antibodies is their selective binding to oligomeric and amyloid aggregates. However, current methods of examining the binding specificities of anti‐amyloid β (Aβ) antibodies have limited ability to differentiate between complexes that form between antibodies and monomeric or oligomeric Aβ species during the dynamic Aβ aggregation process. Here, we present a high‐resolution native ion‐mobility mass spectrometry (nIM‐MS) method to investigate complexes formed … Show more
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