Nationwide survey of the development of drug-resistance in the pediatric field: drug sensitivity of Haemophilus influenzae in Japan

Sakata, Hiroshi; Toyonaga, Y; Sato, Yoshitake; Hanaki, Hideaki; Nonoyama, Masato; Oishi, Tomohiro; Sunakawa, Keisuke

doi:10.1007/s10156-009-0729-1

Cited by 23 publications

(13 citation statements)

References 9 publications

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“…The proportions of ␤-lactam-resistant isolates in general, and specifically BLNARs, are high in Japan and its neighboring countries, as described in several reports (10,11,28). In Europe, reports are less consistent, with some reports suggesting increasing proportions of isolates with ampicillin resistance (14,32), albeit at a lower level than in Japan.…”

mentioning

confidence: 96%

Increase of β-Lactam-Resistant Invasive Haemophilus influenzae in Sweden, 1997 to 2010

Resman

Ristovski

Forsgren

et al. 2012

Antimicrob Agents Chemother

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ABSTRACTThe proportions ofHaemophilus influenzaeresistant to ampicillin and other β-lactam antibiotics have been low in Sweden compared to other countries in the Western world. However, a near-doubled proportion of nasopharyngeal SwedishH. influenzaeisolates with resistance to β-lactams has been observed in the last decade. In the present study, the epidemiology and mechanisms of antimicrobial resistance ofH. influenzaeisolates from blood and cerebrospinal fluid in southern Sweden from 1997 to 2010 (n= 465) were studied. Antimicrobial susceptibility testing was performed using disk diffusion, and isolates with resistance to any tested β-lactam were further analyzed in detail. We identified a significantly increased (P= 0.03) proportion of β-lactam-resistant invasiveH. influenzaeduring the study period, which was mainly attributed to a significant recent increase of β-lactamase-negative β-lactam-resistant isolates (P= 0.04). Furthermore, invasive β-lactamase-negative β-lactam-resistantH. influenzaeisolates from 2007 and onwards were found in higher proportions than the corresponding proportions of nasopharyngeal isolates in a national survey. Multiple-locus sequence typing (MLST) of this group of isolates did not completely separate isolates with different resistance phenotypes. However, one cluster of β-lactamase-negative ampicillin-resistant (BLNAR) isolates was identified, and it included isolates from all geographical areas. A truncated variant of a β-lactamase gene with a promoter deletion,blaTEM-1-PΔ dominated among the β-lactamase-positiveH. influenzaeisolates. Our results show that the proportions of β-lactam-resistant invasiveH. influenzaehave increased in Sweden in the last decade.

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confidence: 96%

Increase of β-Lactam-Resistant Invasive Haemophilus influenzae in Sweden, 1997 to 2010

Resman

Ristovski

Forsgren

et al. 2012

Antimicrob Agents Chemother

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“…1,2 in Japan, H. influenzae type b (Hib) conjugate vaccine and 7-valent pneumococcal conjugate vaccine (PCV7) were introduced for voluntary immunization in december 2008 and February 2010, respectively. these vaccines have only been provided free of charge (but not routine vaccinations) for approximately 90% of areas of Japan since January 2011. the vaccination schedules are standardized 3+1 dose in all areas of Japan.…”

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confidence: 99%

Individual Risk Factors Associated With Nasopharyngeal Colonization With Streptococcus pneumoniae and Haemophilus influenzae

Otsuka

Chang

Shirai

et al. 2013

Pediatric Infectious Disease Journal

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“…BLNAR (beta-lactamase-negative ABPC-resistant), BLNAS (beta-lactamase-negative ABPC-susceptible), or BLPAR (beta-lactamase-positive ABPC-resistant) strains of H. influenzae are approximately 100% susceptible to ceftriaxone, and H. influenzae BLNARstrains are widely spread throughout Japan. 34 Capnocytophaga canimorsus is responsible for dog bite-related infections. The antibiotic susceptibility of 96 isolates of Capnocytophaga sp.…”

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confidence: 99%

Treatment Options for Gram-Positive and Gram-Negative Bacteria: Focus on Ceftriaxone

Hirai¹

2011

Clinical Medicine Reviews in Therapeutics

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Ceftriaxone is a third-generation of cephalosporins which is used for community acquired infections such as pneumonia and urinaly tract infections. It showed great advantage of once-daily administration based on pharmacological manner and need no renal impairment. It is stable for β-lactamases against first-or second-generations of cephalosporins. Ceftriaxone is also used for streptococcal endocarditis as alternative first-line therapeutic regimen and used for Sexually Transmited Disease (STD) such as syphilis and chancoroid. Due to its pharmacological advantage, Ceftriaxone is used for Outpatient Parenteral Antibiotic Therapy (OPAT) with sufficient clinical efficacy in the world. This review focused on therapeutic option or alternative first line therapy of Ceftriaxone and Ceftriaxone in OPAT. The reappraisal of 'traditional antibiotics', such as ceftriaxone, has triggered a review of adequate antibiotic treatment.

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Nationwide survey of the development of drug-resistance in the pediatric field: drug sensitivity of Haemophilus influenzae in Japan

Cited by 23 publications

References 9 publications

Increase of β-Lactam-Resistant Invasive Haemophilus influenzae in Sweden, 1997 to 2010

Increase of β-Lactam-Resistant Invasive Haemophilus influenzae in Sweden, 1997 to 2010

Individual Risk Factors Associated With Nasopharyngeal Colonization With Streptococcus pneumoniae and Haemophilus influenzae

Treatment Options for Gram-Positive and Gram-Negative Bacteria: Focus on Ceftriaxone

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