Nationwide survey of multiple sclerosis in Japan Clinical analysis of 1,084 cases

Kuroiwa, Yoshigoro; Igata, Akihiro; Itahara, Katsuya; Koshijima, Shinzaburo; Tsubaki, Tadao; Toyokura, Y; Shibasaki, Hiroshi

doi:10.1212/wnl.25.9.845

Cited by 176 publications

(102 citation statements)

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“…According to its clinical course, MS can be described as relapsing-remitting type (RR-MS), secondary progressive type (SP-MS), in which a progressive phase follows an initial relapsingremitting phase, or primary progressive type (PP-MS), in which the disease shows a progressive course from its onset. On the other hand, concerning the sites of involvement, there have been several reports that Oriental MS patients more commonly show clinical evidence of major involvement of the optic nerves and spinal cord than Caucasian MS patients (1). In addition, we previously reported the clinical and immunogenetic characteristics of two further MS subtypes in Japanese populations, namely opticospinal MS (OS-MS), in which the clinically estimated main lesions are confined to the optic nerves and spinal cord, and conventional MS (C-MS), which shows disseminated lesions in the central nervous system (CNS), including the cerebrum, cerebellum or brainstem (2-4).…”

Section: Introductionmentioning

confidence: 99%

Comparison of the Clinical Courses of the Opticospinal and Conventional Forms of Multiple Sclerosis in Japan

et al. 2005

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We evaluated the clinical courses of 216 patients with multiple sclerosis (MS) diagnosed according to the recommended diagnostic criteria of McDonald et al (10). Sixty-five patients clinically displaying selective involvement of the optic nerves and spinal cord were classified as opticospinal MS (OS-MS), while the other 151 showing disseminated involvement of the central nervous system were classified as conventional MS (C-MS). The disease duration did not differ significantly between the two subtypes (11.2 years vs. 11.5 years). In addition to a higher age of onset, female preponderance and higher Kurtzke's expanded disability status scale (EDSS) scores, the OS-MS patients showed a markedly lower frequency of secondary progressive MS than the C-MS patients (4.6% vs. 29.1%, p=0.0001). The EDSS scores of the C-MS patients were significantly correlated with the disease duration, while those of the OS-MS patients were not. Among the C-MS patients, the frequency of secondary progressive MS was significantly more common in patients with a disease duration of more than 10 years than in those with a shorter duration. These results suggest that the irreversible disability in OS-MS is determined by relapses, rather than by chronic progression, whereas C-MS has a similar clinical course to MS in Westerners. (Internal Medicine 44: 934-938, 2005)

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Section: Introductionmentioning

confidence: 99%

Comparison of the Clinical Courses of the Opticospinal and Conventional Forms of Multiple Sclerosis in Japan

et al. 2005

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“…It is thought that there are fewer cases of multiple sclerosis (MS) in Japan than in Western countries, and previous studies have emphasized some distinct clinical features of Japanese MS (1)(2)(3)(4). Prevalence studies in Western Europe (5), North America (6) and Southern hemisphere (7,8) have shown an increasing frequency of MS with increasing latitude.…”

Section: Introductionmentioning

confidence: 99%

Multiple Sclerosis in Hokkaido, the Northernmost Island of Japan. Prospective Analyses of Clinical Features.

et al. 1992

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“…From its remitting and exacerbating course, and elevated CSF IgG, the diagnosis of multiple sclerosis was clinically definite, although the patient showed relatively unusual manifestations such as complete quadriplegia, severe visual impairment, epilepsy and deafness. Our former studies,7 8 …”

Section: Discussionmentioning

confidence: 91%

Cortical deafness in multiple sclerosis

Tabira

Tsuji

Nagashima

et al. 1981

Journal of Neurology, Neurosurgery & Psychiatry

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SUMMARY Cortical deafness in a patient with multiple sclerosis is reported. Complete recovery from total deafness was seen following stages of auditory agnosia and pure word deafness. The otological and neurophysiological studies suggested lesions in subcortical white matter. This report stresses the rarity of the condition, its subcortical origin and good prognosis.Cortical deafness is a rare condition, seen in patients with bilateral temporal lobe lesions.' In multiple sclerosis (MS) deafness due to lesions at the lower levels of the auditory pathway is seen in a few per cent2 3 and audiometric examination increases the incidence.4 5 Cortical deafness, however, is rarely observed.3 This report concerns a case of MS with transient cortical deafness and describes the results of otological and neurophysiological studies and its natural course. A preliminary report was published elsewhere.6Case report A 29-year-old right handed man had an acute onset in March, 1977, of numbness on the right side of the body below the neck without any previous symptoms, followed by quadriplegia with some diplopia in April. He was admitted first to Kyushu University Hospital, when neurological examination revealed horizontal nystagmus on lateral gaze, positive Lhermitte's sign, marked quadriplegia with increased knee and ankle jerks, Babinski signs, and some sensory impairment below the level of C5. Cerebrospinal fluid (CSF) contained 0635 g/l total protein (normal range 0-1A4 g/l), 0 108 g/l IgG (0O005-0045 g/l), IgG ratio 1-6 (less than 1-5), and 11 lymphocytes (less than 5) mm-3. Other laboratory data, EEG and CT scan were normal. A diagnosis of acute disseminated encephalomyelitis was made, and corticosteroids were given; the patient recovered.

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Nationwide survey of multiple sclerosis in Japan Clinical analysis of 1,084 cases

Cited by 176 publications

References 0 publications

Comparison of the Clinical Courses of the Opticospinal and Conventional Forms of Multiple Sclerosis in Japan

Comparison of the Clinical Courses of the Opticospinal and Conventional Forms of Multiple Sclerosis in Japan

Multiple Sclerosis in Hokkaido, the Northernmost Island of Japan. Prospective Analyses of Clinical Features.

Cortical deafness in multiple sclerosis

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