Nationwide surveillance of the antimicrobial susceptibility of Chlamydia trachomatis from male urethritis in Japan: Comparison with the first surveillance report

Takahashi, Satoshi; Yasuda, Mitsuru; Wada, Koichiro; Matsumoto, Masahiro; Hayami, Hiroshi; Kobayashi, Kanao; Miyazaki, Jun; Kiyota, Hiroshi; Matsumoto, Tetsuya; Yotsuyanagi, Hiroshi; Tateda, Kazuhiro; Sato, Junko; Hanaki, Hideaki; Masumori, Naoya; Hiyama, Yoshiki; Egawa, Shin; Yamada, Hiroki; Matsumoto, Kazumasa; Ishikawa, Kiyohito; Yamamoto, Shingo; Togo, Yoshikazu; Tanaka, Kazushi; Shigemura, Katsumi; Uehara, Shuichiro; Kohno, Hiroyuki; Kiyoshima, Keijiro; Hamasuna, Ryoichi; Ito, Kenji; Hirayama, Hideo; Kawai, Shozo; Shiono, Yutaka; Maruyama, Takahiro; Ito, Shin; Yoh, Mutsumasa; Ito, Masayasu; Hatano, Koichi; Ihara, Hideari; Uno, Satoshi; Monden, Koichi; Yokoyama, Teruhiko; Takayama, Kazuo; Sumii, Toru; Kadena, Hitoshi; Kawahara, Motoshi; Hosobe, Takahide; Izumitani, Masanobu; Kano, Motonori; Nishimura, Hirofumi; Fujita, Reiko; Kaji, Shinichi; Hayashi, Kenji; Tojo, Takanori; Matumura, Masaru

doi:10.1016/j.jiac.2021.09.012

Cited by 2 publications

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References 12 publications

(18 reference statements)

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“…In contrast, the weak activity of 16 suggests the importance of the methyl group found in ofloxacin, a fluoroquinolone with potent antichlamydial activity ( Figure 4 ) [ 25 ]. Others have shown that newer fluoroquinolones have further improved activity against C. trachomatis , since sitafloxacin and tosufloxacin are more potent than ciprofloxacin and levofloxacin (the optical S-(-) isomer of ofloxacin) [ 26 ] and moxifloxacin is more potent than ofloxacin [ 27 ]. Our data further validated the idea that pre-existing fluoroquinolones can still be modified to improve their activity against C. trachomatis .…”

Section: Resultsmentioning

confidence: 99%

Modified Fluoroquinolones as Antimicrobial Compounds Targeting Chlamydia trachomatis

Adhel

Vielfort

et al. 2022

IJMS

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Chlamydia trachomatis causes the most common sexually transmitted bacterial infection and trachoma, an eye infection. Untreated infections can lead to sequelae, such as infertility and ectopic pregnancy in women and blindness. We previously enhanced the antichlamydial activity of the fluoroquinolone ciprofloxacin by grafting a metal chelating moiety onto it. In the present study, we pursued this pharmacomodulation and obtained nanomolar active molecules (EC50) against this pathogen. This gain in activity prompted us to evaluate the antibacterial activity of this family of molecules against other pathogenic bacteria, such as Neisseria gonorrhoeae and bacteria from the ESKAPE group. The results show that the novel molecules have selectively improved activity against C. trachomatis and demonstrate how the antichlamydial effect of fluoroquinolones can be enhanced.

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Section: Resultsmentioning

confidence: 99%

Modified Fluoroquinolones as Antimicrobial Compounds Targeting Chlamydia trachomatis

Adhel

Vielfort

et al. 2022

IJMS

View full text Add to dashboard Cite

show abstract

“…Taking possible resistant strains into consideration may be unnecessary in most clinical and practical situations. As a result of nationwide surveillance of C. trachomatis antimicrobial susceptibility in Japan, the minimal inhibitory concentrations (MIC90) of ciprofloxacin, levofloxacin, tosufloxacin, sitafloxacin, doxycycline, minocycline, erythromycin, clarithromycin, azithromycin, and solithromycin were shown to be 2, 0.5, 0.25, 0.063, 0.125, 0.125, 0.25, 0.031, 0.125, and 0.008 μg/ml, respectively [52]. This surveillance project did not identify any strains resistant to fluoroquinolone, tetracycline, or macrolide agents, and concluded that antimicrobial susceptibilities were not significantly different from those previously reported [49,52].…”

Section: Antimicrobial Susceptibility Of C Trachomatis In Vitromentioning

confidence: 99%