Nationwide surveillance of bacterial pathogens isolated from patients with acute uncomplicated cystitis in 2018: Conducted by the Japanese Research Group for Urinary Tract Infections (JRGU)

Wada, Koichiro; Yokoyama, Teruhiko; Uno, Satoshi; Araki, Motoo; Sadahira, Takuya; Acosta, Herik; Nakajima, Hirochika; Hiyama, Yoshiki; Kunishima, Yasuharu; Togo, Yoshikazu; Nukaya, Takuhisa; Yamada, Hiroki; Shigemura, Katsumi; Ito, Shin; Tanimura, Masanobu; Kobayashi, Kanao; Kohno, Hiroyuki; Teishima, Jun; Yasuda, Mitsuru; Uehara, Shuichiro; Hamasuna, Ryoichi; Watanabe, Tetsu; Nakagawa, Tohru; Hayami, Hiroshi; Miyazaki, Jun; Takahashi, Satoshi; Masumori, Naoya; Ishikawa, Kiyohito; Kiyota, Hiroshi; Fujisawa, Masato; Arakawa, Soichi; Nasu, Yasutomo; Yamamoto, Shingo

doi:10.1016/j.jiac.2021.03.012

Cited by 7 publications

(5 citation statements)

References 16 publications

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“…[14] In Japan, ESBL-producing E coli and fluoroquinolone-resistant E coli constitute 9.5% to 15% and 15.6% to 30% of all E coli isolates, respectively. [7,15] In this study, the frequency of ESBL-producing E coli was 8.8%, and the frequency of fluoroquinolone-resistant E coli was 11.1%. While these rates fell below those reported in previous studies, they were not insignificant.…”

Section: Discussionmentioning

confidence: 62%

Culture-based bacterial evaluation of the appendix lumen and antibiotic susceptibility of acute appendicitis in Japan: A single-center retrospective analysis

Kitahara,

Park,

Seharada

et al. 2024

Medicine

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The question of whether to perform an appendectomy or conservative treatment for acute appendicitis can differ depending on the facility or surgeon, but antibiotic treatment is administered regardless of whether an appendectomy or conservative treatment is selected. We investigated the contemporary bacteriology for acute appendicitis and evaluated the antibiotic sensitivity of the bacteria that are currently associated with appendicitis. We retrospectively analyzed the bacterial culture results and antibiotic susceptibility of 141 patients who underwent appendicitis surgery, including the identification and antimicrobial susceptibility of the cultured bacteria within the excised appendices. Bacterial cultures were positive in 131 cases (92.9%). The most commonly isolated bacteria were Escherichia coli (90 isolates, 66.7%), followed by Enterococcus species (n = 19, 14.5%), Pseudomonas aeruginosa (n = 18, 13.7%), Streptococcus species (n = 15, 11.5%), and Klebsiella species (n = 8, 6.1%). Eight strains (8.8%) of E coli were extended-spectrum β-lactamase producers, and ten strains (11.1%) were fluoroquinolone-resistant. Tazobactam/piperacillin and meropenem inhibited the growth of 100% of the major identified bacteria. The patients with appendicoliths had a significantly higher bacterial culture rate. Enterococcus species were frequently isolated from the patients with complicated appendicitis. For the antibiotic treatment of appendicitis, it is essential to understand the patient’s microbiological profile and antibiotic susceptibilities. Research from Asian countries such as Japan can enhance our knowledge of regional antibiotic resistance patterns and inform effective treatment strategies.

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Section: Discussionmentioning

confidence: 62%

Culture-based bacterial evaluation of the appendix lumen and antibiotic susceptibility of acute appendicitis in Japan: A single-center retrospective analysis

Kitahara,

Park,

Seharada

et al. 2024

Medicine

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“…Of note, 17.5% (7/40) of patients had ESBL-producing Escherichia coli , especially women, of whom 19.2% (5/26) had ESBL-producing Escherichia coli . Wada et al 18 reported that 6.5% (55/847) ESBL-producing Escherichia coli were detected among non-ESRD women with acute uncomplicated cystitis in a Japanese nationwide survey. Song et al 19 reported that 6.26% (24/383) of non-ESRD female outpatients with intractable recurrent cystitis had ESBL-producing Escherichia coli .…”

Section: Discussionmentioning

confidence: 99%

Urinary Tract Infection in Hemodialysis-Dependent End-Stage Renal Disease Patients

Yamashita¹,

Ishiyama²,

Yoshino³

et al. 2022

RRU

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Introduction The aim of this study was to analyze urinalysis findings and urinary bacterial culture in hemodialysis-dependent end-stage renal disease patients. The research goal was to understand the proportion, risk factors, and the causative organisms of urinary tract infection in hemodialysis-dependent end-stage renal disease patients. Materials and Methods Between May 2020 and June 2021, this study included 100 hemodialysis-dependent end-stage renal disease patients (50 male patients and 50 female patients). The urine underwent microscopic examination, pyuria was defined as ≥5 white blood cells per high-power field, and urinary bacterial cultures were conducted for patients with pyuria. Bacteriuria was defined as ≥10 4 colony-forming units/mL in men and ≥10 5 colony-forming units/mL in women. Daily urine output was investigated by oral listening. Postvoiding residual urine volume was measured. Results Fifty-six percent of male patients and 30% of female patients had normosthenuria, 24% of male patients and 38% of female patients had pyuria, and 20% of male patients and 32% of female patients had a urinary tract infection. A comparison of normosthenuria and urinary tract infection revealed no statistically significant difference in age, time on dialysis, daily urine output, and postvoiding residual urine volume. The proportion of female patients among those with normosthenuria was 34.8%, whereas the proportion of female patients among those with UTI was 61.5%. Urinary bacterial cultures showed that the major causative organisms were Escherichia coli (45%; 18/40 cultures) and extended spectrum beta-lactamase-producing Escherichia coli (17.5%; 7/40 cultures). Conclusion The incidence of urinary tract infection was higher in female patients than in male patients. The proportion of resistant bacteria as the causative organisms was high in hemodialysis-dependent end-stage renal disease patients. Urinary bacterial culture should be checked while patients are able to void urine.

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“…Посів сечі необхідний тільки у низці випадків, таких, як: наявність вагітності, підозра на гострий пієлонефрит, затяжний перебіг циститу (понад 2 тиж), атиповий перебіг захворювання. За наявності у посіві сечі бактерій більше ніж 10 3 можна мікробіологічно підтвердити діагноз гострого циститу [8,9,11].…”

Section: Assessment Of Chronometric Indicators Of the Speed Of The On...unclassified

Assessment of chronometric indicators of the speed of the onset therapeutic effect and prevention of recurrences by using complex phytotherapy in patients with acute uncomplicated cystitis

Nikitin,

Hrytsai,

Klymenko

et al. 2024

RHW

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Urinary tract infections (UTIs) are a significant public health problem. Every year the situation becomes more complicated due to the high rate of recurrence and the growth of resistance among the population.Research results show that about 150 million people suffer from bacterial infections of the urinary tract every year, and about 6 million visits to the doctor about UTIs are registered in the US every year, of which more than 2 million are related to cystitis. In Ukraine, UTIs rank first among all urological diseases, more than 170,000 cystitis patients are registered annually for the first time. 20% of girls till 20 years old have at least one episode of acute cystitis, and 25–40% of women experience a recurrent episode within a year after an episode of acute cystitis.Treatment of cystitis depends on the influence of many factors, which include: age, gender, state of the immune system, recurrences, urological pathologies, severity of the disease and the risk of developing multiple drug resistance. For the prevention of the antibiotic resistance development, it is recommended to use combined herbal preparations for long-term prevention of episodes of recurrent cystitis.The objective: to evaluate the effectiveness of the use of the proposed herbal preparation in the complex treatment and prevention of recurrence in patients with acute uncomplicated cystitis and the chronometry of the onset of action of the drug in monotherapy.Materials and methods. The study was included the patients with acute uncomplicated cystitis. The main group involved 40 persons who were prescribed antibacterial therapy in the form of a single use of fosfomycin trometamol 3 g per os or sulfamethoxazole/trimethoprim 400 mg/80 mg 2 tablets twice a day for 5 days in combination with a herbal preparation (a combination of medicinal plant components of centaury herb, lovage root and rosemary leaves) 1 tablet 3 times a day for 3 months. Patients of the comparison group (40 subjects) received only antibacterial therapy.Treatment effectiveness and side effects were evaluated 10 days after its initiation. Determination of the presence and frequency of recurrence of the disease was carried out 3 and 6 months after its onset. At the second stage of the study, the effectiveness of the use of the herbal preparation was evaluated as a prevention of recurrence of cystitis and relief of its first signs.At the appearance of the first signs of recurrence of the disease within 6 months after the end of the primary course, patients of both groups were recommended to immediately start using the herbal preparation, 1 tablet three times a day. To determine the speed of the onset of the pharmaceutical action of the drug, each patient was asked to fill out a questionnaire regarding the chronometry of the reduction or disappearance of symptoms.Results. After completion of treatment, a positive effect was observed in 38 (95.0%) patients of the main group and 37 (92.5%) of the comparison group, leukocyturia stopped in 39 (97.5%) and 38 (95.0%) patients, respectively, dysuria – in 37 (92.5%) and 38 (95.0%), respectively. The effect of the proposed herbal preparation was maximally manifested in reducing the rate of recurrence of cystitis, which has important clinical significance.It is quite clear that for the occurrence of a sporadic episode of acute cystitis, timely and effective antibiotic therapy is self-sufficient and accordingly hides the effect of phytotherapy. Use of the proposed herbal preparation for 3 months provides long-term rehabilitation of the lower urinary tract due to the aquaretic and antimicrobial effect of the herbal preparation and prevents the recurrence of the disease.Conclusions. The use of the proposed herbal preparation as part of combined therapy in patients with acute uncomplicated cystitis demonstrated its effectiveness in 95.0% of patients. The appointment of the proposed drug of plant origin prevents the occurrence of recurrence in 97.5% of patients, which allows us to recommend it for use in order to prevent relapses of the disease.The use of the proposed preparation of herbal origin helps to reduce the feeling of incomplete emptying of the bladder, starting from 62.9±17.0 min and the disappearance of pollakiuria – by 179.7±23.0 min, which allows to make quick assess of phytotherapy effectiveness and, if necessary to strengthen it in time.

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Nationwide surveillance of bacterial pathogens isolated from patients with acute uncomplicated cystitis in 2018: Conducted by the Japanese Research Group for Urinary Tract Infections (JRGU)

Abstract: Introduction: The aim of this study was to monitor the development of drug-resistant bacteria isolated from acute uncomplicated cystitis (AUC) and to evaluate methodology of the survey conducted by collecting only clinical data.

Cited by 7 publications

References 16 publications

Culture-based bacterial evaluation of the appendix lumen and antibiotic susceptibility of acute appendicitis in Japan: A single-center retrospective analysis

Culture-based bacterial evaluation of the appendix lumen and antibiotic susceptibility of acute appendicitis in Japan: A single-center retrospective analysis

Urinary Tract Infection in Hemodialysis-Dependent End-Stage Renal Disease Patients

Assessment of chronometric indicators of the speed of the onset therapeutic effect and prevention of recurrences by using complex phytotherapy in patients with acute uncomplicated cystitis

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