Nationwide surveillance of antimicrobial consumption and resistance to Pseudomonas aeruginosa isolates at 203 Japanese hospitals in 2010

Muraki, Yuichi; Kitamura, Makiko; Maeda, Yasunori; Kitahara, Takashi; Mori, T; Ikeue, H.; Tsugita, Masami; Tadano, K.; Takada, Kiyonori; Akamatsu, Takashi; Yamada, Takehiro; Shiraishi, Taizo; Okuda, Masahiro

doi:10.1007/s15010-013-0440-0

Cited by 52 publications

(28 citation statements)

References 22 publications

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“…Although viral infections account for the majority of pediatric respiratory infections, antimicrobials are often prescribed for these cases [8,9]. Previous surveys pointed out that the overprescription of oral cephalosporins and macrolides, which are usually prescribed for pediatric respiratory tract infections, is a serious issue in Japan [10,11].…”

Section: Introductionmentioning

confidence: 99%

The impact analysis of a multiplex PCR respiratory panel for hospitalized pediatric respiratory infections in Japan

Kitano

Nishikawa

Suzuki

et al. 2020

Journal of Infection and Chemotherapy

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a b s t r a c tBackground: Rapid molecular diagnosis of infections has contributed to timely treatments and antimicrobial stewardship. However, the benefit and cost-effectiveness vary in each country or community because they have different standard practices and health care systems. In Japan, rapid antigen tests (RATs) have been frequently used for pediatric respiratory infections. We investigated the impact and cost-effectiveness of a multiplex PCR (mPCR) respiratory panel for pediatric respiratory infections in a Japanese community hospital. Methods: We replaced RATs with an mPCR respiratory panel (FilmArray®) for admitted pediatric respiratory infections on March 26, 2018. We compared the days of antimicrobial therapy (DOT) and length of stay (LOS) during the mPCR period (Results: During the RAT and mPCR periods, 1132 and 149 patients were analyzed. The DOT/case was 12.82 vs 8.56 (p < 0.001), and the LOS was 8.18 vs 6.83 days (p ¼ 0.032) in the RAT and mPCR groups, respectively. The total costs during admissions were \258,824 ($2331.7) and \243,841 ($2196.8)/case, respectively. Pathogen detection rates were 30.2% vs 87.2% (p < 0.001). Conclusion: Compared to conventional RATs, the mPCR test contributed to a reduction in the DOT and LOS in a Japanese community hospital for admission-requiring pediatric respiratory infections. However, a proper stewardship program is essential to further reduce the unnecessary usage of antimicrobials.

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Section: Introductionmentioning

confidence: 99%

The impact analysis of a multiplex PCR respiratory panel for hospitalized pediatric respiratory infections in Japan

Kitano

Nishikawa

Suzuki

et al. 2020

Journal of Infection and Chemotherapy

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“…As the new powerful antibiotics, they are used only in intensive care unit (ICU). Linezolid and vancomycin keep very sensitive to S. aureus in our hospital as the last line therapeutic agents for many years to cure MRSA infections, though there were reports about the resistance to Linezolid and vancomycin in the world [8]. For the strict supervision, the susceptibility rate of nitrofurantoin and rifampin are over 90%, the susceptibility rate of moxifloxacin rised to 84.62%.…”

Section: Resultsmentioning

confidence: 88%

“…Skin and soft tissue infections caused by Staphylococcus aureus are commonly encountered [7], so the sputum and secretion/pus specimen accounts a large proportion. The antibiotic protocols suggested improve the proportion of the blood and other sterile site specimen as the basis for the choose antibiotics [8]. Because detecting the microorganism in blood is more accurate and helpful for the Doctor's diagnose than in sputum, though the sputum culture specimen is very easy to obtain.…”

Section: Resultsmentioning

confidence: 99%

Effects of a Restrictive Antibiotic Policy on Antibiotic Usage and Staphylococcus Aureus Resistance

Qiu¹,

Li²,

Jin³

et al. 2016

Advances in Computer Science Research

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Abstract.Objective: This paper aims to report the survey of antimicrobial usage and resistance to Staphylococcus aureus in a local hospital under the restrictive antibiotic policy in China.Methods: We conducted the analysis using retrospective data from 2011 to 2014. The hospital provided data concerning hospital characteristics and infection control policies. The data concerning antibiotic utilization were collected from hospital pharmacy records and reports. The antimicrobial susceptibility test were monitored and recorded in hospital microbiology laboratory.Results: Due to the restrictive antibiotic policy implemented in 2011, antibiotic prescription, antibiotic consumption, antibiotic procurement and prophylactic use of antibiotics in clean operations were all declined. The submission rate of microbial test in antimicrobial therapy increased, but the blood and other sterile site specimen need to be further applied. The broad spectrum antimicrobials and last line drugs still keep a regular susceptibility to Staphylococcus aureus. The factors of high age, long stay in hospital, long time for antibiotic usage and invasive operation were all related to antibiotic resistance.Conclusion: The intervention of antibiotic policy was effective to ensure the rational use of antibiotics.

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“…Quinolones are widely used for the treatment of urinary tract infection, respiratory tract infection and other bacterial infections. Of all antimicrobial agents, the amount of quinolone use is the third highest after that of macrolides and β‐lactams . In particular, topical nadifloxacin and ozenoxacin and oral levofloxacin are used for treatment of skin diseases such as acne vulgaris .…”

Section: Introductionmentioning

confidence: 99%

“…Of all antimicrobial agents, the amount of quinolone use is the third highest after that of macrolides and b-lactams. 6 In particular, topical nadifloxacin and ozenoxacin and oral levofloxacin are used for treatment of skin diseases such as acne vulgaris. 7 We previously reported that the antimicrobial resistance of Cutibacterium (formerly Propionibacterium) acnes isolated from acne patients is affected by antimicrobial use.…”

Section: Introductionmentioning

confidence: 99%

Relationship between quinolone use and resistance of Staphylococcus epidermidis in patients with acne vulgaris

Nakase

Yoshida

Saita

et al. 2019

The Journal of Dermatology

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Staphylococcus epidermidis is a bacterium known to inhabit the skin. In treatment of acne vulgaris, the cutaneous milieu is exposed to oral or topical antimicrobials. We previously reported that the antimicrobial resistance of Cutibacterium acnes isolated from acne patients is affected by antimicrobial use. The aim of this study was to investigate the relationship between quinolone use and resistance in skin bacteria, particularly S. epidermidis, from acne patients. A total of 92 and 87 S. epidermidis strains isolated from clinic patients and hospital outpatients with acne vulgaris, respectively, were tested. No significant difference was found between the prevalence of methicillin‐resistant S. epidermidis (MRSE) strains from clinic patients (37.0%) and hospital outpatients (39.1%). The MRSE strains (20.6%, 14/68 strains) showed a significantly higher ratio of high‐level levofloxacin resistance (minimum inhibitory concentrations were 64 to ≥256 μg/mL) compared with methicillin‐susceptible S. epidermidis strains (2.7%, 3/111 strains) (P < 0.01). The rate of levofloxacin resistance in C. acnes strains, which were isolated from the same samples of acne patients, showed a strong positive correlation with that in S. epidermidis strains (r = 0.93, P < 0.01). The high‐level levofloxacin‐resistant strains were frequently found in patients with history of quinolone use compared with those without (P < 0.01). Our data showed for the first time that antimicrobial administration for acne treatment affects the antimicrobial resistance in not only C. acnes but also S. epidermidis. Thus, caution should be exercised in antimicrobial use for acne treatment to prevent increasing antimicrobial resistance in these species.

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Nationwide surveillance of antimicrobial consumption and resistance to Pseudomonas aeruginosa isolates at 203 Japanese hospitals in 2010

Abstract: This is the first national surveillance study of antimicrobial consumption in Japan. A continuous surveillance program in Japan is necessary in order to evaluate the association among resistance, antimicrobial restriction, and consumption.

Cited by 52 publications

References 22 publications

The impact analysis of a multiplex PCR respiratory panel for hospitalized pediatric respiratory infections in Japan

The impact analysis of a multiplex PCR respiratory panel for hospitalized pediatric respiratory infections in Japan

Effects of a Restrictive Antibiotic Policy on Antibiotic Usage and Staphylococcus Aureus Resistance

Relationship between quinolone use and resistance of Staphylococcus epidermidis in patients with acne vulgaris

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