Nationwide Increase in the Incidence of Retinopathy of Prematurity in the US—A Growing Problem?

Ying, Gui‐Shuang; Quinn, Graham E.

doi:10.1001/jamaophthalmol.2023.0926

Cited by 2 publications

(5 citation statements)

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“…[2,[6][7][8][9][10] These variations are related to global differences in neonatal care, oxygen use, and mortality of premature infants. [11] Moreover, the studies themselves differ in the definition of the target population for investigating ROP incidence. [11] Various nationwide administrative datasets exist for medical research on children and adults in Korea.…”

Section: Introductionmentioning

confidence: 99%

“…[11] Moreover, the studies themselves differ in the definition of the target population for investigating ROP incidence. [11] Various nationwide administrative datasets exist for medical research on children and adults in Korea. [12,13] In addition, studies on ROP epidemiology have been conducted using the National Health Insurance database.…”

Section: Introductionmentioning

confidence: 99%

“…[ 2 , 6 – 10 ] These variations are related to global differences in neonatal care, oxygen use, and mortality of premature infants. [ 11 ] Moreover, the studies themselves differ in the definition of the target population for investigating ROP incidence. [ 11 ]…”

Section: Introductionmentioning

confidence: 99%

“…[ 11 ] Moreover, the studies themselves differ in the definition of the target population for investigating ROP incidence. [ 11 ]…”

Section: Introductionmentioning

confidence: 99%

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The incidence and risk factors of retinopathy of prematurity in South Korea: A nationwide cohort study

Jung,

Moon

2024

Medicine

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Retinopathy of prematurity (ROP) is a major treatable cause of childhood blindness. Thus, epidemiological investigations are necessary for detecting and preventing ROP. Determining risk factors for ROP are also essential to improve screening methods. Therefore, we aimed to investigate the incidence and risk factors of ROP in Korea. The National Health Insurance Service (NHIS) covers almost all Koreans. Furthermore, the National Health Screening Program for Infants and Children (NHSPIC) is a government-run, health-screening program for children aged < 6 years. We used the NHIS-Infants and Children’s Health Screening cohort database to evaluate the incidence of preterm infants and ROP. The database contains data on 84,005 participants, drawn from 5% of the NHSPIC survey on participants born annually during 2008 to 2012. Sociodemographic factors and systemic diseases were assessed as potential risk factors for ROP. We identified 2615 premature infants (3.11%); 846 of them had ROP (cumulative incidence: 32.4%). Although preterm births increased annually in 2008 to 2012, the ROP incidence in preterm infants did not increase by the birth year. Twenty patients (2.4%) with ROP underwent laser photocoagulation or surgery. Extremely low birth weight was a high risk factor (odds ratio [OR] = 49.86, P < .001). Moreover, chorioamnionitis (OR = 2.77, P = .028), respiratory distress syndrome (OR = 4.09, P < .001), apnea (OR = 1.59, P = .008), anemia (OR = 2.41, P < .001), and intraventricular hemorrhage (OR = 2.34, P < .001) were found to be risk factors for ROP. In conclusion, the incidence of premature babies increased between 2008 and 2012. However, the overall incidence of ROP among premature infants remained unchanged by birth year. Our findings revealed the roles of birth weight, respiratory conditions, anemia, and intraventricular hemorrhage in ROP.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…[ 11 ] Moreover, the studies themselves differ in the definition of the target population for investigating ROP incidence. [ 11 ]…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The incidence and risk factors of retinopathy of prematurity in South Korea: A nationwide cohort study

Jung,

Moon

2024

Medicine

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“…Of the proliferative retinopathies, ROP, although less prevalent, has attracted much attention because of its increasing incidence rate among premature infants with low body weight. In USA, for instance, ROP increased from 4.4% in 2003 to 8.1% in 2019 (86% relative increase) nationwide with the largest increase found in Black (5.8%–11.6%) and Hispanic infants (4.6%–8.2%) ( Ying and Quinn, 2023 ). In this respect, ROP is a leading cause of blindness in children worldwide due to increasing survival rates of premature infants also in developing countries because of the improvement in the nursing care of high-risk newborn babies.…”

Section: Introductionmentioning

confidence: 99%

A promising case of preclinical-clinical translation: β-adrenoceptor blockade from the oxygen-induced retinopathy model to retinopathy of prematurity

Cammalleri,

Filippi,

Dal Monte

et al. 2024

Front. Physiol.

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Although compartmentalization of the eye seems to promote its experimental manipulation, drug penetration to its posterior part is severely limited by hard barriers thus hindering drug development for eye diseases. In particular, angiogenesis-related retinal diseases share common mechanisms and are responsible for the majority of cases of blindness. Their prevalence is globally increasing mostly because of the increased incidence of systemic pathologies in the adult. Despite the number of preclinical findings demonstrating the efficacy of novel treatments, therapy of retinal neovascular diseases still remains confined to intravitreal anti-vascular endothelial growth factor treatments with some extension to anti-inflammatory therapy. In the mare magnum of preclinical findings aimed to develop novel avenues for future therapies, most compounds, despite their efficacy in experimental models, do not seem to meet the criteria for their therapeutic application. In particular, the groove between preclinical findings and their clinical application increases instead of decreasing and the attempt to bridging the gap between them creates intense frustration and a sense of defeat. In this complex scenario, we will discuss here the role that overactivation of the sympathetic system plays in retinal vessel proliferation in response to hypoxia using the oxygen-induced retinopathy (OIR) model. The potential application of the beta-adrenoceptor (β-AR) blockade with propranolol to the treatment of retinopathy of prematurity will be also discussed in light of preclinical findings in the OIR model and clinical trials using propranolol in preterm infants either per os or as eye drops.

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Nationwide Increase in the Incidence of Retinopathy of Prematurity in the US—A Growing Problem?

Abstract: The continuing ROP training of ophthalmologists along with the use of technological advances is needed to meet the growing demand of optimal ROP management of at-risk premature infants.

Cited by 2 publications

References 9 publications

The incidence and risk factors of retinopathy of prematurity in South Korea: A nationwide cohort study

The incidence and risk factors of retinopathy of prematurity in South Korea: A nationwide cohort study

A promising case of preclinical-clinical translation: β-adrenoceptor blockade from the oxygen-induced retinopathy model to retinopathy of prematurity

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