Nationwide Distribution of Bovine Influenza D Virus Infection in Japan

Horimoto, Taisuke; Hiono, Takahiro; Mekata, Hirohisa; Odagiri, Tomoha; Lei, Zhihao; Kobayashi, T.; Norimine, Junzo; Inoshima, Yasuo; Hikono, Hirokazu; Murakami, Kenji; Sato, Reiichiro; Murakami, Hironobu; Sakaguchi, Masahiro; Ishii, Kazunori; Ando, Takaaki; Otomaru, Konosuke; Ozawa, Makoto; Sakoda, Yoshihiro; Murakami, Shin

doi:10.1371/journal.pone.0163828

Cited by 53 publications

(59 citation statements)

References 18 publications

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“…However, several metagenomic analyses have suggested that this virus plays an important role as an inducer of BRD (Mitra et al., ; Ng et al., ). The diffuse seropositivity of cattle in Japan and the full‐genome sequence of a Japanese strain of the influenza D virus (D/bovine/Ibaraki/7768/2016) have already been reported by Horimoto's group (Horimoto et al., ; Murakami et al., ). D/bovine/Ibaraki/7768/2016 has several unique amino acids and is genetically distant from strains found in other countries.…”

Section: Introductionmentioning

confidence: 79%

“…However, both strains from Japan possessed serine at this position. A previous antibody survey revealed that the antigenicity of D/bovine/Ibaraki/7768/2016 was more similar to D/OK‐type than to D/660‐type (Horimoto et al., ). However, the antigenicity difference between D/OK‐type and the Japanese strain (D/Japan‐type) remains unknown.…”

Section: Discussionmentioning

confidence: 99%

“…However, subsequent surveys revealed that cattle, not pigs, are the natural reservoirs of this virus (Collin et al., ; Hause et al., ). This virus has already been identified in North America, Europe and East Asia (Chiapponi et al., ; Ducatez, Pelletier, & Meyer, ; Ferguson et al., ; Horimoto et al., ; Jiang et al., ; Mitra, Cernicchiaro, Torres, Li, & Hause, ; Murakami et al., ). A limited serological survey shows that not only cattle and pigs but also sheep and goats are susceptible to this virus (Quast et al., ).…”

Section: Introductionmentioning

confidence: 90%

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Molecular epidemiological survey and phylogenetic analysis of bovine influenza D virus in Japan

Mekata

Yamamoto

Hamabe

et al. 2017

Transbound Emerg Dis

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The influenza D virus, a new member of the Orthomyxoviridae family, is predominantly found in cattle. Although viral pathology and clinical disease in cattle appear mild, this virus plays an important role as a trigger of bovine respiratory disease (BRD). BRD is a costly illness worldwide. Thus, epidemiological surveys of the influenza D virus are necessary. Here, we conducted a molecular epidemiological survey for the influenza D virus in healthy and respiratory-diseased cattle in Japan. We found that 2.1% (8/377) of the cattle were infected with influenza D. The cattle with and without respiratory symptoms had approximately equal amounts of the virus. A full-genome sequence analysis revealed that the influenza D virus that was isolated in Japan formed an individual cluster that was distinct from the strains found in other countries. These results suggest that this virus might have evolved uniquely in Japan over a long period of time and that the viral pathology of Japanese strains might be different from the strains found in other countries. Continuous surveillance is required to determine the importance of this virus and to characterize its evolution.

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Section: Introductionmentioning

confidence: 79%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 90%

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Molecular epidemiological survey and phylogenetic analysis of bovine influenza D virus in Japan

Mekata

Yamamoto

Hamabe

et al. 2017

Transbound Emerg Dis

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“…Epidemiological analyses revealed that cattle are the main host of the virus, due to their high seroprevalence for IDV (2, 3). Further epidemiological studies revealed that IDVs circulate in cattle in many countries including the USA (2–4), Mexico (5), China (6), Japan (7, 8), France (9), Italy (10), Ireland (11), Luxembourg (12), and African countries (13). Furthermore, serological studies showed that IDV antibodies are found in pigs (14), sheep (15, 16), goats (15, 16), dromedary camels (13, 17), horses (18), and humans (19).…”

Section: Introductionmentioning

confidence: 99%

Establishment of a Reverse Genetics System for Influenza D Virus

Ishida

Murakami

Kamiki

et al. 2019

Preprint

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250 words 15 Text 4,170 words 16 2 ABSTRACT Influenza D virus (IDV) was initially isolated in the USA in 2011. IDV is 17distributed worldwide and is one of the causative agents of bovine respiratory disease 18 complex (BRDC), which exhibits high morbidity and mortality in feedlot cattle. 19 Molecular mechanisms of IDV pathogenicity are still unknown. Reverse genetics 20 systems are vital tools not only for studying the biology of viruses, but also for use in 21 applications such as recombinant vaccine viruses. Here, we report the establishment of a 22 plasmid-based reverse genetics system for IDV. We first verified that the 3′-terminal 23 nucleotide of each 7-segmented genomic RNA contained uracil in contrary to the 24 previous report, and were then able to successfully generate recombinant IDV by 25 co-transfecting 7 plasmids containing these genomic RNAs along with 4 plasmids 26 expressing polymerase proteins and NP into HRT-18G cells. The recombinant virus had 27 a growth deficit compared to the wild-type virus, and we determined the reason for this 28 growth difference by examining the genomic RNA content of the viral particles. We 29 found that recombinant virus incorporated an unbalanced ratio of viral RNA segments 30 into particles as compared to the wild-type virus, and thus we adjusted the amount of 31 each plasmid used in transfection to obtain recombinant virus with the same replicative 32 capacity as wild-type virus. Our work here in establishing a reverse genetics system for 33 IDV will have a broad range of applications, including uses in studies focused on better 34 understanding IDV replication and pathogenicity as well as those contributing to the 35 development of BRDC countermeasures. 36 37 IMPORTANCE Bovine respiratory disease complex (BRDC) exhibits high mortality 38 and morbidity in cattle, causing economic losses worldwide. Influenza D virus (IDV) is 39 considered to be a causative agent of BRDC. Here, we developed a reverse genetics 40 3 system that allows for the generation of IDV from cloned cDNAs, and the introduction 41 of mutations into the IDV genome. This reverse genetics system will become a 42 powerful tool for use in studies related to understanding the molecular mechanisms of 43 viral replication and pathogenicity, and will also lead to the development of new 44 countermeasures against BRDC. 45 46 KEYWORD bovine respiratory disease complex, influenza D virus, mutant, 47 recombinant virus, reverse genetics, transfection 48 49 50 Influenza D virus (IDV), a member of the family Orthomyxoviridae, was first isolated 52 from pigs with respiratory illness in Oklahoma, USA, in 2011 (1, 2). Epidemiological 53 analyses revealed that cattle are the main host of the virus, due to their high 54 seroprevalence for IDV (2, 3). Further epidemiological studies revealed that IDVs 55 circulate in cattle in many countries including the USA (2-4), Mexico (5), China (6), 56 Japan (7, 8), France (9), Italy (10), Ireland (11), Luxembourg (12), and African 57 countries (13). Furthermore, serolo...

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“…Since its discovery, both IDV and anti-IDV antibodies have been successfully detected in North and Central America, Europe, Asia, and Africa (12,(14)(15)(16)(17)(18)(19)(20)(21). While IDV is thought to be circulating among several mammalian species (14), cattle are considered to be the primary host and reservoir.…”

mentioning

confidence: 99%

Pathogenesis, Host Innate Immune Response, and Aerosol Transmission of Influenza D Virus in Cattle

Salem

Hägglund

Cassard

et al. 2019

J Virol

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The recently discovered influenza D virus (IDV) of the Orthomyxoviridae family has been detected in swine and ruminants with a worldwide distribution. Cattle are considered to be the primary host and reservoir, and previous studies suggested a tropism of IDV for the upper respiratory tract and a putative role in the bovine respiratory disease complex. This study aimed to characterize the pathogenicity of IDV in naive calves as well as the ability of this virus to transmit by air. Eight naive calves were infected by aerosol with a recent French isolate, D/bovine/France/5920/2014. Results show that IDV replicates not only in the upper respiratory tract but also in the lower respiratory tract (LRT), inducing moderate bronchopneumonia with restricted lesions of interstitial pneumonia. Inoculation was followed by IDV-specific IgG1 production as early as 10 days postchallenge and likely both Th1 and Th2 responses. Study of the innate immune response in the LRT of IDV-infected calves indicated the overexpression of pathogen recognition receptors and of chemokines CCL2, CCL3, and CCL4, but without overexpression of genes involved in the type I interferon pathway. Finally, virological examination of three aerosol-sentinel animals, housed 3 m apart from inoculated calves (and thus subject to infection by aerosol transmission), and IDV detection in air samples collected in different areas showed that IDV can be airborne transmitted and infect naive contact calves on short distances. This study suggests that IDV is a respiratory virus with moderate pathogenicity and probably a high level of transmission. It consequently can be considered predisposing to or a cofactor of respiratory disease. IMPORTANCE Influenza D virus (IDV), a new genus of the Orthomyxoviridae family, has a broad geographical distribution and can infect several animal species. Cattle are so far considered the primary host for IDV, but the pathogenicity and the prevalence of this virus are still unclear. We demonstrated that under experimental conditions (in a controlled environment and in the absence of coinfecting pathogens), IDV is able to cause mild to moderate disease and targets both the upper and lower respiratory tracts. The virus can transmit by direct as well as aerosol contacts. While this study evidenced overexpression of pathogen recognition receptors and chemokines in the lower respiratory tract, IDV-specific IgG1 production as early as 10 days postchallenge, and likely both Th1 and Th2 responses, further studies are warranted to better understand the immune responses triggered by IDV and its role as part of the bovine respiratory disease complex. FIG 1 (A) Experiment timeline and sampling. D0 is the day of inoculation. (B)Fourteen naive calves were allocated to two separated pens, one with 5 mock-infected calves (control group) and the second with 11 calves. In the latter pen, calves were divided into two groups separated by steel panels, 3 m apart. Eight calves (direct-inoculated group) were inoculated at day 0 (D0) with 10 7 TCID 50 of IDV 5...

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Nationwide Distribution of Bovine Influenza D Virus Infection in Japan

Cited by 53 publications

References 18 publications

Molecular epidemiological survey and phylogenetic analysis of bovine influenza D virus in Japan

Molecular epidemiological survey and phylogenetic analysis of bovine influenza D virus in Japan

Establishment of a Reverse Genetics System for Influenza D Virus

Pathogenesis, Host Innate Immune Response, and Aerosol Transmission of Influenza D Virus in Cattle

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