National variation in United States sepsis mortality: a descriptive study

Wang, Henry E.; Devereaux, Randolph S.; Yealy, Donald M.; Safford, Monika M.; Howard, George

doi:10.1186/1476-072x-9-9

Cited by 103 publications

(98 citation statements)

References 30 publications

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“…Fourth, there is no universally accepted scheme for classifying various causes of death into categories. The groupings that we used were on the basis of clinically relevant categories and informed by several validated algorithms, 21 previously published data, 22 and recommendations from experts. 23,24 Fifth, our results must be interpreted carefully given that more severe CKD is much less common than milder forms: a disease that accounts for a lower proportion of deaths at higher eGFR may actually account for a substantially greater number of deaths than another disease that is responsible for a higher proportion of deaths among people with severe CKD.…”

Section: Discussionmentioning

confidence: 99%

Cause of Death in Patients with Reduced Kidney Function

Thompson

James

Wiebe

et al. 2015

Journal of the American Society of Nephrology

475

325

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Information on common causes of death in people with CKD is limited. We hypothesized that, as eGFR declines, cardiovascular mortality and mortality from infection account for increasing proportions of deaths. We calculated eGFR using the CKD Epidemiology Collaboration equation for residents of Alberta, Canada who died between 2002 and 2009. We used multinomial logistic regression to estimate unadjusted and age-and sex-adjusted differences in the proportions of deaths from each cause according to the severity of CKD. Cause of death was classified as cardiovascular, infection, cancer, other, or not reported using International Classification of Diseases codes. Among 81,064 deaths, the most common cause was cancer (31.9%) followed by cardiovascular disease (30.2%). The most common cause of death for those with eGFR$60 ml/min per 1.73 m 2 and no proteinuria was cancer (38.1%); the most common cause of death for those with eGFR,60 ml/min per 1.73 m 2 was cardiovascular disease. The unadjusted proportion of patients who died from cardiovascular disease increased as eGFR decreased (20.7%, 36.8%, 41.2%, and 43.7% of patients with eGFR$60 [with proteinuria], 45-59.9, 30-44.9, and 15-29.9 ml/min per 1.73 m 2 , respectively). The proportions of deaths from heart failure and valvular disease specifically increased with declining eGFR along with the proportions of deaths from infectious and other causes, whereas the proportion of deaths from cancer decreased. In conclusion, we found an inverse association between eGFR and specific causes of death, including specific types of cardiovascular disease, infection, and other causes, in this cohort.

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Section: Discussionmentioning

confidence: 99%

Cause of Death in Patients with Reduced Kidney Function

Thompson

James

Wiebe

et al. 2015

Journal of the American Society of Nephrology

475

325

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show abstract

“…Sepsis Mortality: A Descriptive Study, Wang et al [11], using National Center for Health Statistics' Compressed Mortality File (CMF) as a primary data source, come to the findings that "National age-adjusted sepsis mortality was 65.5 per 100,000 persons (95% CI: 65.8 -66.0). State level sepsis mortality varied more than two-fold (range 41 to 88.6 per 100,000 persons; median 60.8 per 100,000, IQR 53.9-74.4 per 100,000)".…”

Section: Furthermore In the Study National Variation In United Statesmentioning

confidence: 99%

Analysis of Studies on the Role and/or Impact of Public Health Information Systems on Improving Population-Level Outcomes Research

Casimir¹

2015

MOJPH

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“…(1)(2)(3) Identification of patients with increased risk of death is dramatically important, but because of the lack of early diagnosis markers, diagnosis can be delayed and mortality increased. Thus, finding biomarkers for establishing early diagnosis and indicating prognosis of sepsis is very important.…”

Section: Introductionmentioning

confidence: 99%