National Trends, Risk Factors, and Outcomes of Acute In-Hospital Stroke Following Lung Transplantation in the United States

Shou, Benjamin L.; Wilcox, Christopher S.; Florissi, Isabella; Krishnan, Aravind; Kim, Bo Soo; Keller, Steven P.; Whitman, Glenn; Uchino, Ken; Bush, Errol L.; Cho, Sung Min

doi:10.1016/j.chest.2023.04.007

Cited by 2 publications

(2 citation statements)

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“…3 Stroke is a well-characterized complication of isolated heart, singleand double-lung transplantation. 4,5 Patients with end-stage cardiopulmonary failure experience chronic hypoxia, which increases the brain's susceptibility to ischemic insults. Preoperative hemodynamics, iatro- genic coagulopathy, and long cardiopulmonary bypass time due to procedural complexity in HLTx may predispose patients to postoperative stroke.…”

Section: Introductionmentioning

confidence: 99%

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Incidence, risk factors, and outcomes of postoperative stroke in combined heart‐lung transplantation: A retrospective cohort study of the UNOS registry

Akbar,

Shou,

Casillan

et al. 2023

Clinical Transplantation

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Stroke is a well‐characterized complication of isolated heart and lung transplantation, but has not been described in combined heart‐lung transplantation (HLTx). We retrospectively reviewed national U.S. data to describe the incidence, risk factors, and impact of postoperative stroke in HLTx recipients. Of 871 heart‐lung recipients between 1994–2022, 35 (4.0%) experienced stroke, and the incidence increased over time, trending toward significance (p‐trend = .07). After adjustment, extracorporeal membrane oxygenation (ECMO) (Adjusted odds ratio [aOR] = 2.63, 95%CI = [1.13–6.11]) and pre‐transplant implantable defibrillator (aOR = 2.86, 95%CI = [1.20–6.81]) were independent risk factors for stroke. Postoperative stroke is common and is increasing in an era where organ allocation is driven by mechanical circulatory support (MCS) bridging.

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Section: Introductionmentioning

confidence: 99%

“…3 MCS use in heart and lung transplantation has been shown to increase post-transplant stroke risk. 4,7 While postoperative stroke has been described in isolated heart and isolated lung transplantation, similar characterization has not been performed for HLTx. We sought to describe the incidence, risk…”

Section: Introductionmentioning

confidence: 99%