National Trends in Acellular Dermal Matrix Utilization in Immediate Breast Reconstruction

Graziano, Francis D.; Plotsker, Ethan L.; Rubenstein, Robyn; Haglich, Kathryn; Stern, Carrie S.; Matros, Evan; Nelson, Jonas A.

doi:10.1097/prs.0000000000010575

Cited by 3 publications

(1 citation statement)

References 47 publications

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“…This highlights the advantages of using tissue-engineered biocompatible solutions instead of synthetic products. A study by Graziano et al ( 30 ), based on the American Cancer Society database, focused on national outcomes of prepectoral breast reconstruction. They found that most (55%) of direct-to-implant reconstructions utilized ADM.…”

Section: Literature Review Of Tissue- and Bio-engineering Approaches ...mentioning

confidence: 99%

Tissue engineering strategies for breast reconstruction: a literature review of current advances and future directions

Berkane,

Oubari,

van Dieren

et al. 2024

Ann Transl Med

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Background and Objective Mastectomy is a primary treatment for breast cancer patients, and both autologous and implant-based reconstructive techniques have shown excellent results. In recent years, advancements in bioengineering have led to a proliferation of innovative approaches to breast reconstruction. This article comprehensively explores the promising perspectives offered by bioengineering and tissue engineering in the field of breast reconstruction. Methods A literature review was conducted between April and June 2023 on PubMed and Google Scholar Databases. All English and French articles related to bioengineering applied to the field of breast reconstruction were included. We used the Evidence-Based Veterinary Medicine Association (EBVM) Toolkit 14 checklist for narrative reviews as a quality assurance measure and the Scale for the Assessment of Narrative Review Articles (SANRA) tool to self-assess our methodology. Key Content and Findings Over 130 references related to breast bioengineering were included. The analysis revealed four key applications: enhancing the quality of the skin envelope, improving the viability of fat grafting, creating breast shape and volume via bio-printing, and optimizing nipple reconstruction through engineering techniques. The primary identified approaches revolved around establishing structural support and enhancing cellular viability. Structural techniques predominantly involved the implementation of 3D printed, decellularized, or biocompatible material scaffolds. Meanwhile, promoting cellular content trophicity primarily focused on harnessing the regenerative potential of adipose-derived stem cells (ADSCs) and increasing the tissue’s survivability and cell trophicity. Conclusions Tissue and bioengineering hold immense promise in the field of breast reconstruction, offering a diverse array of approaches. By combining existing techniques with novel advancements, they have the potential to significantly enhance the therapeutic options available to plastic and reconstructive surgeons.

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Section: Literature Review Of Tissue- and Bio-engineering Approaches ...mentioning

confidence: 99%

Tissue engineering strategies for breast reconstruction: a literature review of current advances and future directions

Berkane,

Oubari,

van Dieren

et al. 2024

Ann Transl Med

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Statistical fragility of outcomes in acellular dermal matrix literature: A systematic review of randomized controlled trials

Wang,

Kwon,

Kim

et al. 2024

Journal of Plastic, Reconstructive & Aesthetic Surgery

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Complications and Burden of 2-Stage Tissue Expander to Implant-Based Reconstructive Surgery: A Single-Center Retrospective Study

Churchill,

Gallo,

Dunn

et al. 2023

Plast Surg (Oakv)

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Introduction: Two-stage reconstruction with a tissue expander/implant (TE/I) technique remains the most common breast reconstructive approach following mastectomy. This study analyzes the post-operative complications and burden associated with 2-stage TE/I reconstruction independent of acellular dermal matrix (ADM). Methods: A retrospective chart review identified patients that underwent 2-stage, reconstruction with TE/I without ADM. Demographics, implant characteristics, tissue expansion information, and complications were recorded. Patients were followed for 3 months post-implant exchange. Logistic regression analysis was used to determine which variables were predictors for complications. Results: Ninety-one TE/I reconstructions without ADM were performed in 55 patients. The incidence of complications was 45% (n = 25). Mean complications per patient was 0.84 ± 1.2, with the most common being infection with the TE (n = 15, 24.2%). Mean number of fill appointments was 3.6 ± 1.7 (range: 1-8). Univariate linear regression showed for every increase in BMI, there was a 14.8 cc increase in implant volume, on average ( P < .001). Multivariable logistic regression model identified radiation history ( P = .036) and increasing BMI ( P = .049) as significant predictors for complications. Conclusion: Infection remains to be the leading cause of short-term complications in TE/I breast reconstruction patients. BMI and radiation are significant predictors. Larger, multicenter observational study data may elicit nuanced variation among different population demographics.

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National Trends in Acellular Dermal Matrix Utilization in Immediate Breast Reconstruction

Cited by 3 publications

References 47 publications

Tissue engineering strategies for breast reconstruction: a literature review of current advances and future directions

Tissue engineering strategies for breast reconstruction: a literature review of current advances and future directions

Statistical fragility of outcomes in acellular dermal matrix literature: A systematic review of randomized controlled trials

Complications and Burden of 2-Stage Tissue Expander to Implant-Based Reconstructive Surgery: A Single-Center Retrospective Study

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