National Trends and Outcomes of Nonautoimmune Hemolytic Anemia in Alcoholic Liver Disease

Tariq, Tooba; Karabon, Patrick; Irfan, Furqan B.; Sieloff, Eric M.; Patterson, Rachel A.; Desai, Archita P.

doi:10.1097/mcg.0000000000001383

Cited by 3 publications

(3 citation statements)

References 17 publications

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“…Spur cell anemia especially often accompanies cases of alcoholic liver disease. 16 The name of the disease is derived from the characteristic morphology of erythrocytes, which are enlarged and develop thorny-like processes. The primary mechanism behind Records idenƟfied through other sources n = 58 IdenƟficaƟon spur cell anemia are changes in cholesterol to phospholipid ratio.…”

Section: Hemolytic Anemiamentioning

confidence: 99%

“…18 The risk of spur cell anemia development is 2 times higher in women with alcoholic liver disease. 16 Patients who, besides alcoholic liver disease, have other comorbidities, especially chronic obstructive pulmonary disease (COPD), are at a higher risk of spur cell anemia. Tariq et al hypothesize in their study that COPD and alcoholic liver disease can have common destructive mechanisms of action towards red cell membranes through increased reactive oxygen species (ROS) production in both diseases.…”

Section: Hemolytic Anemiamentioning

confidence: 99%

“…Tariq et al hypothesize in their study that COPD and alcoholic liver disease can have common destructive mechanisms of action towards red cell membranes through increased reactive oxygen species (ROS) production in both diseases. 16 Spur cell anemia is associated with a poor prognosis and a reported average survival time of 1 year. 19 Scarce reports suggest that liver transplantation can play a curative role in both liver disease and spur cell anemia.…”

Section: Hemolytic Anemiamentioning

confidence: 99%

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Rare causes of anemia in liver diseases

Dawidowski¹,

Pietrzak²

2022

Adv Clin Exp Med

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Anemia is a common finding among patients with liver diseases. Patients who suffer from anemia are at a higher risk of liver function decompensation and hospitalization. It affects significantly their quality of life and contributes to mortality. Anemia is present in 70% of patients with liver cirrhosis and with varying incidence accompanies other liver disorders. As the etiology of anemia in liver diseases is multifactorial, various cases represent different clinical entities. Anemia accompanying hepatic disorders can be broadly divided into several types, such as anemia associated with blood loss, as well as aplastic, hemolytic and micronutrient deficiency anemia. However, it is sometimes difficult to delineate between those types in the clinical practice, as several pathophysiological causes can be present in one patient. It is reported that the most common cause of anemia in liver disease is blood loss and iron deficiency. Still, the incidence of unclear cases reaching over 50% suggests that other types of anemia can be underdiagnosed. This review comprehensively describes less frequent types of anemia associated with liver disease, namely hemolytic and aplastic anemia (AA). Hemolytic anemia can complicate autoimmune liver diseases or be a manifestation of membranopathy of red blood cells, dependent on severe hepatic function impairment or alcoholic liver disease. Aplastic anemia is best known as a sequela of viral hepatitis, but some degree of bone marrow inhibition can complicate virtually all advanced liver diseases.

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Section: Hemolytic Anemiamentioning

confidence: 99%

Section: Hemolytic Anemiamentioning

confidence: 99%