National trend of heart failure and other cardiovascular diseases in people living with human immunodeficiency virus

Park, Dae Yong; An, Seokyung; Romero, Maria Emilia; Murthi, Mukunthan; Atluri, Ramtej

doi:10.4330/wjc.v14.i7.427

Cited by 4 publications

(1 citation statement)

References 27 publications

(28 reference statements)

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“…Factors such as low health literacy, poverty, unemployment, and low physical activity also persist in the Deep South at higher rates compared with other regions of the United States (Enogela et al, 2022). With the high prevalence of CMDs among PLWH in this region, some of its unique challenges for QoL outcomes include hospitalizations, polypharmacy, and increased health care needs (Danjuma et al, 2022; Gabuzda et al, 2020; Gao et al, 2021; Park et al, 2022).…”

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confidence: 99%

Cardiometabolic Diseases and Quality-of-Life Outcomes in Adults With HIV in the Deep South: A Cross-sectional Study

Enogela¹,

Buford²,

Vance³

et al. 2022

J Assoc Nurses AIDS Care

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The role of cardiometabolic diseases (CMDs) on physical health-related quality of life (P-HRQoL) and quality of sleep was examined among 261 PLWH $40 years, recruited from a university-affiliated HIV clinic in the Deep U.S. South. Using a cross-sectional study design, participants completed the Medical Outcomes Study HIV Health Survey (MOS-HIV; P-HRQoL) and Pittsburgh Sleep Quality Index. The overall prevalence of self-reporting $1 CMD was 64.4%. P-HRQoL scores were lower in PLWH with $1 CMD compared with those with no CMDs (45.53 6 11.54 vs. 49.67 6 10.77, p ,.01). Poor sleep quality was higher among participants with $1 CMD compared with those with no CMDs (9.28 6 4.42 vs. 7.26 6 4.17, p,.01). Each additional CMD resulted in a 1.83-point decrease in P-HRQoL and 0.74-point increase in poor sleep quality scores. Interventions that focus on targeting these quality-of-life domains in PLWH with CMDs are needed.

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confidence: 99%

Cardiometabolic Diseases and Quality-of-Life Outcomes in Adults With HIV in the Deep South: A Cross-sectional Study

Enogela¹,

Buford²,

Vance³

et al. 2022

J Assoc Nurses AIDS Care

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Mortality and comorbidities in a Nationwide cohort of HIV-infected adults: comparison to a matched non-HIV adults’ cohort, France, 2006–18

Vallée,

Majerholc,

Zucman

et al. 2024

European Journal of Public Health

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Background Human immunodeficiency virus (HIV) remains a significant cause of morbidity and mortality worldwide. The aim of this study was to describe the mortality rate and associated comorbidities in a nationwide population-based cohort of persons living with HIV (PLWHIV) and to compare it with mortality in an age and gender-matched cohort of non-HIV individuals in France. Methods Using data from the French national health data system, we identified and included 173 712 PLWHIV (66.5% men) and 173 712 non-HIV participants (66.5% men) matched for age and gender. PLHIV were identified based on ICD-10 HIV diagnoses, HIV-specific laboratory tests, and/or prescriptions for antiretroviral therapy specific to HIV. Hazard ratios (HRs) of mortality were assessed using multiple Cox regression models. Results During the 13 years of follow-up (2006–18), we observed 20 018 deaths among PLWHIV compared with 6262 deaths among non-HIV participants (11.52% vs. 3.60%, P < 0.001). The over-mortality of PLWHIV was expressed by univariable HR = 2.135 (2.072–2.199), which remained significant after adjustment for region, Complementary Universal Health Insurance and AME, with multivariable HR = 2.182 (2.118–2.248). The results remained significant after adjusting for comorbidities, including infectious diseases [HR = 1.587 (1.538–1.638)]. Notably, PLWHIV were more importantly associated with mortality in women [HR = 2.966 (2.767–3.180)], compared in men [HR = 1.961 (1.898–2.027)]. Conclusion Although the life expectancy of PLWHIV has globally increased, the causes of death should be prioritized in prevention policies and care management. Gender-specific policies should be highlighted, as we observed a higher impact of HIV mortality in women.

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Six month incidence of major adverse cardiovascular events among adults with HIV in northern Tanzania: a prospective observational study

Stark,

O'Leary,

Sakita

et al. 2023

BMJ Open

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ObjectivesWe aimed to prospectively describe incident cardiovascular events among people living with HIV (PLWH) in northern Tanzania. Secondary aims of this study were to understand non-communicable disease care-seeking behaviour and patient preferences for cardiovascular care and education.DesignA prospective observational study.SettingThis study was conducted at the Majengo HIV Care and Treatment Clinic, an outpatient government-funded clinic in Moshi, TanzaniaParticipantsAdult patients presenting to an HIV clinic for routine care in northern Tanzania were enrolled from 1 September 2020 to 1 March 2021.InterventionsAt enrolment, participants completed a survey and a resting 12-lead ECG was obtained. At 6 month follow-up, a repeat survey regarding interim health events and repeat ECG was obtained.Primary and secondary outcome measuresInterim major adverse cardiovascular events (MACE) were defined by: self-reported interim stroke, self-reported hospitalisation for heart failure, self-reported interim myocardial infarction, interim myocardial infarction by ECG criteria (new pathologic Q waves in two contiguous leads) or death due to cardiovascular disease (CVD).ResultsOf 500 enrolled participants, 477 (95.4%) completed 6 month follow-up and 3 (0.6%) died. Over the 6 month follow-up period, 11 MACE occurred (3 strokes, 6 myocardial infarctions, 1 heart failure hospitalisation and 1 cardiovascular death), resulting in an incidence rate of 4.58 MACE per 100 person-years. Of participants completing 6 month follow-up, 31 (6.5%) reported a new non-communicable disease diagnosis, including 23 (4.8%) with a new hypertension diagnosis.ConclusionsThe incidence of MACE among PLWH in Tanzania is high. These findings are an important preliminary step in understanding the landscape of CVD among PLWH in Tanzania and highlight the need for interventions to reduce cardiovascular risk in this population.

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National trend of heart failure and other cardiovascular diseases in people living with human immunodeficiency virus

Cited by 4 publications

References 27 publications

Cardiometabolic Diseases and Quality-of-Life Outcomes in Adults With HIV in the Deep South: A Cross-sectional Study

Cardiometabolic Diseases and Quality-of-Life Outcomes in Adults With HIV in the Deep South: A Cross-sectional Study

Mortality and comorbidities in a Nationwide cohort of HIV-infected adults: comparison to a matched non-HIV adults’ cohort, France, 2006–18

Six month incidence of major adverse cardiovascular events among adults with HIV in northern Tanzania: a prospective observational study

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