National survey of invasive pneumococcal diseases in Taiwan under partial PCV7 vaccination in 2007: Emergence of serotype 19A with high invasive potential

Hsieh, Yao‐Ching; Lin, Pen Yi; Chiu, Cheng Hsun; Huang, Yhu Chering; Chang, Kuang Yi; Liao, Chun-Hsing; Chiu, Nan Chang; Chuang, Yin Ching; Chen, Po Yen; Chang, Shan Chwen; Liu, Jien Wei; Yen, Muh Yong; Wang, Jen Hsien; Liu, Cheng Yi; Lin, Tzou Yien

doi:10.1016/j.vaccine.2009.06.091

Cited by 97 publications

(64 citation statements)

References 29 publications

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“…This may have resulted in over-estimating real incidences of resistance among non-meningitis isolates while underestimating them among strains isolated from the central nervous system. The effect of different interpretation criteria was clearly shown recently by Hsieh Y-C et al [66] reporting on sterile-site isolates recovered from over 500 invasive disease episodes in Taiwan during 2007. While 67.8% of the isolates were non-suceptible to penicillin using the meningitis criteria, only 7.7% fell into this catergory with the non-meningitis breakpoints.…”

Section: Streptococcus Pneumoniaementioning

confidence: 88%

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Update on Antibacterial Resistance in Low-Income Countries: Factors Favoring the Emergence of Resistance

Vilà

Pál

2010

TOIDJ

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Antimicrobial resistance has increased drastically in recent years in the developing countries, and it has rapidly become a leading public health concern. The prevalence of antimicrobial resistance varies greatly between and within countries and between different pathogens. However, overall a trend to the increase of the resistance to those antimicrobial agents more often used in these countries has been observed. Several factors can contribute to the rapid emergence and dissemination of antimicrobial resistance. In this paper, the current antimicrobial resistance in different microorganisms from different countries as well as the factors contributing to the emergence and spread of resistance in developing countries will be reviewed.

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Section: Streptococcus Pneumoniaementioning

confidence: 88%

“…Recent studies noted further significant increases in penicillin resistance in some areas of the region, notably in Taiwan [66] and in China [79] and most of the regional differences have recently been confirmed [80].…”

Section: Streptococcus Pneumoniaementioning

confidence: 99%

Update on Antibacterial Resistance in Low-Income Countries: Factors Favoring the Emergence of Resistance

Vilà

Pál

2010

TOIDJ

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“…However, there is still pronounced underestimation of IPD incidence other than meningitis due to insufficient blood culturing together with a long tradition of meningitis notification in Poland. This is illustrated by a very high proportion of meningitis (34.0 %) among all Polish IPD cases in comparison to other countries with more complete surveillance where the percentage is four to eight times lower [25][26][27][28]. The visible enhancement of the Polish surveillance system is associated with improved patient data completeness.…”

Section: Discussionmentioning

confidence: 99%

Recent trends in epidemiology of invasive pneumococcal disease in Poland

Skoczyńska

Kuch

Sadowy

et al. 2014

Eur J Clin Microbiol Infect Dis

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The objectives of this study were to assess the current incidence of invasive pneumococcal disease (IPD) in Poland (2011-2013), where mass vaccination has not been implemented, and to characterize the Streptococcus pneumoniae isolates responsible for invasive infections by determining their serotype distribution and antimicrobial resistance patterns. For all isolates identification, serotyping and antimicrobial minimal inhibitory concentrations determination were performed based on routine techniques. The highest incidence rates were observed among adults older than 85 years old (4.62/100,000) and children under 1 year of age (4.28/100,000). The general case fatality ratio (CFR) was 25.4%, with the highest CFR in the age group ≥85 years old (59.7%). The most common serotypes were 3, 14, 19A, 4, 9V, 19F, 1, and 23 F (61.3% of all isolates). The 10- and 13-valent pneumococcal conjugated vaccines (PCV) covered 46.0 and 71.8% of all IPD cases, 61.4 and 79.5% of cases in children under two years, and 60.4 and 78.6% of cases involving children under five years of age, respectively. The PCV13 and 23-valent polysaccharide vaccine covered 68.7 and 86.0% of cases in adults >65 years old, respectively. Decreased susceptibility was noted for penicillin (24.8%), cefotaxime (10.0%), meropenem (5.0%), rifampicin (0.8%), chloramphenicol (4.3%), erythromycin (29.7%) and clindamycin (25.6%). Multi-drug resistance characterized 21.6% of the pneumococci tested. Despite deficiencies in the Polish surveillance system and strong underestimation of IPD cases, results of the study showed good theoretical coverage of PCV, which should encourage inclusion of anti-pneumococcal conjugate vaccine into the national immunization program.

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“…63 Epidemiologic and costs inputs from Malaysia and Hong Kong are presented in Tables 6 and 7. The rates of IPD in Malaysia were extrapolated from the Taiwan study of Hsieh et al 64 The rates of all-cause hospitalized pneumonia were estimated from a previous Malaysian PCV7 cost-effectiveness study by Aljunid et al 14 As there are no known nationwide epidemiological data on all-cause outpatient pneumonia in Malaysia, the incidence was estimated from the 2012 HIMS(Health Information Management System) unpublished data from the Health Informatics publication from Ministry of Health in Malaysia. The total outpatient attendances for year 2012 were 49,602,486 where the breakdown attendances are 7,828,297, 7,151,109, 24,196,003 and 10,427,095 for various age groups <10 y, 10-19y, 20-59y and >60 y, Note.…”

Section: Epidemiological Datamentioning

confidence: 99%

Cost-effectiveness analysis of infant universal routine pneumococcal vaccination in Malaysia and Hong Kong

Roberts

Lee

et al. 2015

Human Vaccines & Immunotherapeutics

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Keywords: herd effect, incremental cost-effectiveness ratio (ICER), Markov transition-state model, pneumococcal disease, 13-valent pneumococcal conjugate vaccine (PCV13), 10-valent pneumococcal conjugate vaccine (PCV10)Pneumococcal disease causes large morbidity, mortality and health care utilization and medical and non-medical costs, which can all be reduced by effective infant universal routine immunization programs with pneumococcal conjugate vaccines (PCV). We evaluated the clinical and economic benefits of such programs with either 10-or 13-valent PCVs in Malaysia and Hong Kong by using an age-stratified Markov cohort model with many country-specific inputs. The incremental cost per quality-adjusted life year (QALY) was calculated to compare PCV10 or PCV13 against no vaccination and PCV13 against PCV10 over a 10-year birth cohort's vaccination. Both payer and societal perspectives were used. PCV13 had better public health and economic outcomes than a PCV10 program across all scenarios considered. For example, in the base case scenario in Malaysia, PCV13 would reduce more cases of IPD (C2,296), pneumonia (C705,281), and acute otitis media (C376,967) and save more lives (C6,122) than PCV10. Similarly, in Hong Kong, PCV13 would reduce more cases of IPD cases (C529), pneumonia (C172,185), and acute otitis media (C37,727) and save more lives (C2,688) than PCV10. During the same time horizon, PCV13 would gain over 74,000 and 21,600 additional QALYs than PCV10 in Malaysia and Hong Kong, respectively. PCV13 would be cost saving when compared against similar program with PCV10, under both payer and societal perspective in both countries. PCV13 remained a better choice over PCV10 in multiple sensitivity, scenario, and probabilistic analyses. PCV13s broader serotype coverage in its formulation and herd effect compared against PCV10 were important drivers of differences in outcomes.

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National survey of invasive pneumococcal diseases in Taiwan under partial PCV7 vaccination in 2007: Emergence of serotype 19A with high invasive potential

Cited by 97 publications

References 29 publications

Update on Antibacterial Resistance in Low-Income Countries: Factors Favoring the Emergence of Resistance

Update on Antibacterial Resistance in Low-Income Countries: Factors Favoring the Emergence of Resistance

Recent trends in epidemiology of invasive pneumococcal disease in Poland

Cost-effectiveness analysis of infant universal routine pneumococcal vaccination in Malaysia and Hong Kong

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