National surveillance of invasive pneumococcal diseases in Taiwan, 2008–2012: Differential temporal emergence of serotype 19A

Chiang, Chuen‐Sheue; Chen, Ying Yan; Jiang, Shr Fong; Liu, Ding-Ping; Kao, Pei Hsiu; Teng, Hwa Jen; Kuo, Tsung Lin; Yao, Shu Man; Tseng, Lei Ron; Wang, Yu Lan; Wu, Ho Sheng; Chang, Feng Yee; Lin, Tzou Yien

doi:10.1016/j.vaccine.2014.04.061

Cited by 32 publications

(32 citation statements)

References 24 publications

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“…IPD results in high global morbidity and mortality each year [ 2 ], but it is a vaccine-preventable disease [ 3 – 5 ]. Its incidence decreased after the introduction of a seven-valent pneumococcal conjugate vaccine (PCV7) in the private sector in Taiwan in October 2005 [ 6 , 7 ]. The estimated coverage rate of PCV7 vaccination was 5.7 % in 2006 and 45.5 % in 2010 among children <5 years of age.…”

Section: Introductionmentioning

confidence: 99%

Clinical features and outcomes of invasive pneumococcal disease in a pediatric intensive care unit

Hsiao

Huang

et al. 2015

BMC Pediatr

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BackgroundInvasive pneumococcal disease (IPD) results in high morbidity and mortality globally each year, although it is a vaccine-preventable disease. This study aimed to characterize the clinical features of IPD in a pediatric intensive care unit (PICU) in Taiwan. The seven-valent pneumococcal conjugate vaccine (PCV7) was introduced in the private sector in October 2005. The estimated coverage rate of PCV7 vaccination in 2010 was 45.5 % among children <5 years of age.MethodsWe conducted a retrospective study at a single center in northern Taiwan for invasive pneumococcal disease in a PICU from 2009 to 2013. Demographic characteristics, clinical courses, serotype, antibiotic susceptibility, and outcomes were analyzed.ResultsOver the 5-year study period, 2167 patients were admitted to the PICU; 48 (2.2 %) had IPD. There were 29 female and 19 male patients. Their mean age was 3.7 years (range 0.7–12.5 years, with the peak age at 2–5 years; n = 30, 63 %). Pneumonia was the most frequent type (n = 38, 79 %), followed by meningitis (n = 10, 21 %). In total, three patients died, all within 72 h after admission; the final diagnoses were all meningitis. Thirty-four children with pneumonia received chest tube insertion for pleural effusion drainage. Of them, 22 (65 %) finally still underwent video-assisted thoracoscopic surgery. Eight (17 %) children had hemolytic uremic syndrome, and seven of them underwent hemodialysis. In total, 37 serotypes were detected; 95 % were covered by PCV13. Serotype 19A was most common (54 %) overall; however, in those with meningitis, serotype 19 F was most common.ConclusionsMeningitis is the most severe type of invasive pneumococcal disease in our pediatric intensive care unit. It may progress rapidly even when subjects are given antibiotics promptly. The most common serotype in meningitis is 19 F, which is vaccine preventable. Thus, universal mass pneumococcal vaccination is still needed.

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Section: Introductionmentioning

confidence: 99%

Clinical features and outcomes of invasive pneumococcal disease in a pediatric intensive care unit

Hsiao

Huang

et al. 2015

BMC Pediatr

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“…However, the vaccine was provided for free for infants with immunocompromised conditions, those in vulnerable socio‐economic status and those with inadequate health‐care resources . From 2008 to 2012, the incidence of invasive pneumococcal diseases decreased by 36.4% for infants under 2 years of age, and this was attributed to the increase in pneumococcal vaccination . Thus, the aforementioned significant decrease in infantile sepsis incidence and mortality over time, especially the discrepancy between respiratory tract infections and urinary tract infections, might be related to childhood vaccination.…”

Section: Discussionmentioning

confidence: 99%

Trend and outcome of sepsis in children: A nationwide cohort study

Hsu

Lee

et al. 2018

J Paediatrics Child Health

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“…Streptococcus pneumonia infection is a major cause of morbidity and mortality worldwide. 1 Following the introduction of pneumococcal conjugate vaccines (PCVs), the incidence of invasive pneumococcal diseases (IPDs) has decreased. 1 Seven-valent PCV (PCV7) has been available in Taiwan since late 2005.…”

Section: Introductionmentioning

confidence: 99%

“…1 Following the introduction of pneumococcal conjugate vaccines (PCVs), the incidence of invasive pneumococcal diseases (IPDs) has decreased. 1 Seven-valent PCV (PCV7) has been available in Taiwan since late 2005. Serotype 19A, which is a non-PCV7 serotype, became the most prevalent S. pneumoniae serotype in 2010.…”

Section: Introductionmentioning

confidence: 99%

“…Serotype 19A, which is a non-PCV7 serotype, became the most prevalent S. pneumoniae serotype in 2010. 1 A national booster program, providing a single dose of 13-valent PCV (PCV13) to children aged between 2 years and 5 years, was implemented in Taiwan in 2013. 2 IPD due to serotype 19A increased significantly, from 1.7 cases/100,000 people in 2008 to 10.3 cases/100,000 people in 2012, followed by a substantial decrease to 5.6 cases/100,000 people in 2013.…”

Section: Introductionmentioning

confidence: 99%

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