National Monitoring for Antimicrobial Resistance among Indicator Bacteria Isolated from Food-Producing Animals in Japan

Kojima, Akira; Asai, Tetsuo; Ishihara, Katsuya; Morioka, Ayako; Akimoto, Keiko; Sugimoto, Yasushi; Sato, Tsuyoshi; Tsutsumi, Yutaka; Takahashi, Toshio

doi:10.1292/jvms.001301

Cited by 36 publications

(35 citation statements)

References 15 publications

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“…This is in accord with previous studies in laying hens [17,18,29]. The overall limited antimicrobial usage in egg-producing laying hens, as shown in the results, could play a role in this observation since it is generally accepted that the use of antimicrobials is one of the major risk factors for the development and spread of antimicrobial resistance [30,31].…”

Section: Discussionsupporting

confidence: 92%

Antimicrobial resistance ofEscherichia coliandEnterococcus faecalisin housed laying-hen flocks in Europe

et al. 2010

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The aim of this study was to determine the potential association between housing type and multiple drug resistance (MDR) in Escherichia coli and Enterococcus faecalis isolates recovered from 283 laying-hen flocks. In each flock, a cloacal swab from four hens was collected and produced 1102 E. coli and 792 E. faecalis isolates. Broth microdilution was used to test susceptibility to antimicrobials. Country and housing type interacted differently with the MDR levels of both species. In the E. coli model, housing in a raised-floor system was associated with an increased risk of MDR compared to the conventional battery system [odds ratio (OR) 2·12, 95% confidence interval (CI) 1·13-3·97)]. In the E. faecalis model the MDR levels were lower in free-range systems than in conventional battery cages (OR 0·51, 95% CI 0·27-0·94). In Belgium, ceftiofur-resistant E. coli isolates were more numerous than in the other countries. SUMMARYThe aim of this study was to determine the potential association between housing type and multiple drug resistance (MDR) in Escherichia coli and Enterococcus faecalis isolates recovered from 283 laying-hen flocks. In each flock, a cloacal swab from four hens was collected and produced 1102 E. coli and 792 E. faecalis isolates. Broth microdilution was used to test susceptibility to antimicrobials. Country and housing type interacted differently with the MDR levels of both species. In the E. coli model, housing in a raised-floor system was associated with an increased risk of MDR compared to the conventional battery system [odds ratio (OR) 2 . 12, 95 % confidence interval (CI) 1 . 13-3 . 97)]. In the E. faecalis model the MDR levels were lower in free-range systems than in conventional battery cages (OR 0 . 51,. In Belgium, ceftiofur-resistant E. coli isolates were more numerous than in the other countries.

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Section: Discussionsupporting

confidence: 92%

Antimicrobial resistance ofEscherichia coliandEnterococcus faecalisin housed laying-hen flocks in Europe

et al. 2010

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“…Similar results were obtained in several species of intestinal bacteria of animal origins, for example enterococci [15,16] and E. coli [15]. In Japan, antimicrobial use is largest in swine farming among the domestic animal industry, followed by broiler chickens [10].…”

Section: Discussionsupporting

confidence: 75%

Prevalence and Mechanism of Antimicrobial Resistance in Staphylococcus aureus Isolates from Diseased Cattle, Swine and Chickens in Japan

Baba

Ishihara

Ozawa

et al. 2012

The Journal of Veterinary Medical Science

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ABSTRAcT. Antimicrobial administration is essential for the control and treatment of diseases in animals, but the emergence and prevalence of antimicrobial-resistant Staphylococcus aureus is a significant concern during animal production. Here we investigated the antimicrobial susceptibility of S. aureus from diseased food-producing animals and molecularly characterized the methicillin-resistant and fluoroquinolone-resistant isolates. A total of 290 S. aureus isolates obtained from cattle (n=246), swine (n=16), and chickens (n=28) between 2003 and 2009 were examined for antimicrobial susceptibility against 9 antimicrobials using an agar dilution method. Resistance to penicillin (PC) was most frequently found (24.8%), followed by oxytetracycline (OTC, 10.0%), dihydrostreptomycin (4.1%), erythromycin (EM, 3.1%), enrofloxacin (ERFX, 2.1%), and kanamycin (1.7%). The PC resistance rate was significantly higher in swine than in cattle (P<0.01) and chickens (P<0.01). The resistance rates to OTC, EM and ERFX were significantly higher in swine and chickens than in cattle (P<0.05). Methicillin-resistant S. aureus (MRSA) was recovered from milk derived from a cow with mastitis in 2003; sequence type 8, SCCmec type IV and spa type t024. In the six ERFX-resistant strains isolated after 2003, amino acid substitutions in ParC with/without GyrA were detected. As the prevalence of MRSA and FQ-resistant S. aureus in the animals should be noticed, continuous monitoring is necessary to control resistance to clinically important antimicrobials in S. aureus from food-producing animals.

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“…Breakpoints established by the CLSI [4] were used for the following antimicrobial agents: ABPC, CEZ, CP, MINO, KM, GM, NAL, and FOM. MICs of ERFX, OTC and CL were interpreted using the resistance breakpoints reported by Kojima et al [13]. No breakpoint is available for OXA and OBFX.…”

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confidence: 99%

Antimicrobial Susceptibility of <i>Escherichia coli</i> Isolated from Feces of Wild Cranes Migrating to Kagoshima, Japan

Kitadai

Obi

Yamashita

et al. 2012

The Journal of Veterinary Medical Science

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ABSTRACT. Susceptibility to 13 antimicrobial agents was examined for 138 Escherichia coli isolates obtained from 192 fecal samples of wild cranes that migrated for wintering to the Izumi plain, Kagoshima prefecture in Japan. The numbers of isolates that were resistant to the antimicrobials used in this study are as follows: oxytetracycline (OTC), 22 isolates; minocycline, 7 isolates; ampicillin (ABPC), 4 isolates; nalidixic acid, 4 isolates; enrofloxacin, 2 isolates; kanamycin, one isolate. Multidrug resistant isolates exhibiting 2-4 drug resistances were obtained. All of the OTC-resistant isolates carried either the tet (A) or tet(B) gene. The bla TEM gene was found in all of the ABPC-resistant isolates.

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National Monitoring for Antimicrobial Resistance among Indicator Bacteria Isolated from Food-Producing Animals in Japan

Cited by 36 publications

References 15 publications

Antimicrobial resistance ofEscherichia coliandEnterococcus faecalisin housed laying-hen flocks in Europe

Antimicrobial resistance ofEscherichia coliandEnterococcus faecalisin housed laying-hen flocks in Europe

Prevalence and Mechanism of Antimicrobial Resistance in Staphylococcus aureus Isolates from Diseased Cattle, Swine and Chickens in Japan

Antimicrobial Susceptibility of <i>Escherichia coli</i> Isolated from Feces of Wild Cranes Migrating to Kagoshima, Japan

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