National Institutes of Health Consensus Development Conference: Lactose Intolerance and Health

Suchy, Frederick J.

doi:10.7326/0003-4819-152-12-201006150-00248

Cited by 173 publications

(222 citation statements)

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“…Lactose malabsorption refers to inefficient digestion of lactose due to reduced expression or impaired activity of the enzyme lactase. After ingestion, lactose passes into the small intestine where it comes into contact with lactase at the intestinal brush border and hydrolysed into the monosaccharides: glucose and galactose, which can be readily absorbed [11].…”

Section: Introductionmentioning

confidence: 99%

Malabsorption, Orocecal Transit Time and Small Intestinal Bacterial Overgrowth in Type 2 Diabetic Patients: A Connection

et al. 2016

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Type 2 diabetes mellitus consists of dysfunctions characterized by hyperglycemia and resulting from combination of resistance to insulin action and inadequate insulin secretion. Most of diabetic patients report significant gastrointestinal symptoms. Entire GI tract can be affected by diabetes from oral cavity to large bowel and anorectal region. Proteins, carbohydrates, fats, and most fluids are absorbed in small intestine. Malabsorption may occurs when proper absorption of nutrients does not take place due to bacterial overgrowth or altered gut motility. The present study was planned to measure various malabsorption parameters in type 2 diabetic patients. 175 patients and 175 age and sex matched healthy controls attending Endocrinology Clinic in PGI, Chandigarh were enrolled. Lactose intolerance was measured by using noninvasive lactose hydrogen breath test. Urinary D-xylose and fecal fat were estimated using standard methods. Orocecal transit time and small intestinal bacterial overgrowth were measured using non-invasive lactulose and glucose breath test respectively. Out of 175 diabetic patients enrolled, 87 were males while among 175 healthy subjects 88 were males. SIBO was observed in 14.8 % type 2 diabetic patients and in 2.8 % of controls. There was statistically significant increase (p \ 0.002) in OCTT in type 2 diabetic patients compared with controls. OCTT was observed to be more delayed (p \ 0.003) in patients who were found to have SIBO than in patients without SIBO. Lactose intolerance was observed in 60 % diabetic patients and 39.4 % in controls. Urinary D-xylose levels were also lower in case of diabetic patients but no significant difference was found in 72 h fecal fat excretion among diabetic patients and controls. Urinary D-xylose and lactose intolerance in SIBO positive type 2 diabetic patients was more severe as compared to SIBO negative diabetic patients. From this study we can conclude that delayed OCTT may have led to SIBO which may have instigated the process of malabsorption among type 2 diabetic patients.

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Section: Introductionmentioning

confidence: 99%

Malabsorption, Orocecal Transit Time and Small Intestinal Bacterial Overgrowth in Type 2 Diabetic Patients: A Connection

et al. 2016

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“…4,7 There is considerable confusion about the terms "lactose intolerance" and "milk allergy". Reported reactions to foods are often believed to be manifestations of a food allergy.…”

Section: Lactose Intolerance and Healthmentioning

confidence: 99%

“…Lactose intolerance can be diagnosed by having individuals ingest a standard dose of lactose after fasting and finding elevated levels of breath hydrogen which is produced by bacterial fermentation of undigested lactose in the colon. 4 A recent systematic review by Jellema et al 7 found that the diagnostic performance of reported symptoms that are associated with lactose intolerance (diarrhoea, abdominal pain, bloating and flatulence) was highly variable. More firm associations were found for ethnicity.…”

Section: Diagnosing Lactose Intolerancementioning

confidence: 99%

“…Individuals may demonstrate reduced peak bone mass, increased incidence of osteopenia and greater risk of osteoporosis and bone fractures. 1,4 Wilt et al 1 systematically reviewed evidence to determine the prevalence of lactose intolerance, bone health after diets that exclude dairy and a tolerable dose of lactose in subjects with diagnosed lactose intolerance and management. They reported that the lactose intolerance magnitude was very low in children and remained low in adulthood in individuals of Northern European descent.…”

Section: Lactose Intolerance and Healthmentioning

confidence: 99%

“…Congenital lactase deficiency is a very rare, autosomal recessive genetic disorder that prevents lactase expression from birth. [1][2][3][4] The frequency of decreased lactase activity ranges from 5% in northern Europe, through 71% in Sicily, to more than 90% in some African and Asian countries. 5 Previously, lactase deficiency was reported to be common among black South Africans (78%).…”

Section: Introductionmentioning

confidence: 99%

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