National Institute on Aging–Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease

Hyman, Bradley T.; Phelps, Creighton H.; Beach, Thomas G.; Bigio, Eileen H.; Cairns, Nigel J.; Carrillo, María C.; Dickson, Dennis W.; Duyckaerts, Charles; Frosch, Matthew P.; Masliah, Eliezer; Mirra, Suzanne S.; Nelson, Peter T.; Schneider, Julie A.; Thal, Dietmar Rudolf; Thies, Bill; Trojanowski, John Q.; Vinters, Harry V.; Montine, Thomas J.

doi:10.1016/j.jalz.2011.10.007

Cited by 2,070 publications

(1,988 citation statements)

References 104 publications

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“…Neuropathologic diagnosis was made using previously published neuropathologic criteria, including Braak stages,18, 19 Consortium to Establish a Registry for Alzheimer's Disease scores,19, 20 Thal A β phases,19, 21 LBD pathologic criteria,11 and FTLD classification22 by neuropathologists who were blinded to the 123 I‐FP‐CIT SPECT findings.…”

Section: Methodsmentioning

confidence: 99%

Clinicopathological and ¹²³I‐FP‐CIT SPECT correlations in patients with dementia

Jung

Jordan

Lowe

et al. 2018

Ann Clin Transl Neurol

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The relationship between clinicopathologic diagnosis and 123I‐FP‐CIT SPECT in 18 patients with dementia (12 with Lewy body disease) from one center in the United States was assessed. The sensitivity and specificity of abnormal 123I‐FP‐CIT SPECT with reduced striatal uptake on visual inspection for predicting Lewy body disease were 91.7% and 83.3%, respectively. The mean calculated putamen to occipital ratio (mPOR) based on regions of interest was significantly reduced in Lewy body disease compared to non‐Lewy body disease cases (P = 0.002). In this study, abnormal 123I‐FP‐CIT SPECT was strongly associated with underlying Lewy body disease pathology, supporting the utility of 123I‐FP‐CIT SPECT in the clinical diagnosis of dementia with Lewy bodies.

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Section: Methodsmentioning

confidence: 99%

Clinicopathological and ¹²³I‐FP‐CIT SPECT correlations in patients with dementia

Jung

Jordan

Lowe

et al. 2018

Ann Clin Transl Neurol

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“…The two most important neuropathological features of AD are cerebral Aβ-amyloid neuritic plaques in neocortical terminal fields, and neurofibrillary tangles (NFTs) containing phosphorylated tau protein [12][13][14] initially in medial temporallobe structures and later in many forebrain and midbrain areas. Microvascular amyloid deposition (amyloid angiopathy), granulovacuolar degeneration, loss of neurons and white matter, synapse loss, gliosis, inflammation, and oxidative damage are other pathological changes present in AD [12][13][14][15].…”

Section: Neuropathology Of the Visual System In Admentioning

confidence: 99%

“…Microvascular amyloid deposition (amyloid angiopathy), granulovacuolar degeneration, loss of neurons and white matter, synapse loss, gliosis, inflammation, and oxidative damage are other pathological changes present in AD [12][13][14][15].…”

Section: Neuropathology Of the Visual System In Admentioning

confidence: 99%

Alzheimer’s disease: A review of its visual system neuropathology. Optical coherence tomography—a potential role as a study tool in vivo

Cunha

Moura-Coelho

Proença

et al. 2016

Graefes Arch Clin Exp Ophthalmol

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Alzheimer's disease (AD) is a prevalent, long-term progressive degenerative disorder with great social impact. It is currently thought that, in addition to neurodegeneration, vascular changes also play a role in the pathophysiology of the disease. Visual symptoms are frequent and are an early clinical manifestation; a number of psychophysiologic changes occur in visual function, including visual field defects, abnormal contrast sensitivity, abnormalities in color vision, depth perception deficits, and motion detection abnormalities. These visual changes were initially believed to be solely due to neurodegeneration in the posterior visual pathway. However, evidence from pathology studies in both animal models of AD and humans has demonstrated that neurodegeneration also takes place in the anterior visual pathway, with involvement of the retinal ganglion cells' (RGCs) dendrites, somata, and axons in the optic nerve. These studies additionally showed that patients with AD have changes in retinal and choroidal microvasculature. Pathology findings have been corroborated in in-vivo assessment of the retina and optic nerve head (ONH), as well as the retinal and choroidal vasculature. Optical coherence tomography (OCT) in particular has shown great utility in the assessment of these changes, and it may become a useful tool for early detection and monitoring disease progression in AD. The authors make a review of the current understanding of retinal and choroidal pathological changes in patients with AD, with particular focus on invivo evidence of retinal and choroidal neurodegenerative and microvascular changes using OCT technology.

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“…The amount of neurofibrillary tangles formed by the tau protein correlates with cognitive decline in AD [11]. The presence of characteristic protein deposits in brain tissue postmortem remains the definitive diagnostic proof of Creutzfeld-Jacob disease and AD [130,131]. Drugs that have mechanisms of action similar to the Orcein derivatives could thus make a valuable contribution to validating the oligomer hypothesis in vivo.…”

Section: Reducing Proteotoxicity By Promoting Fibril Formationmentioning

confidence: 99%

Natural Compounds May Open New Routes to Treatment of Amyloid Diseases

Bieschke

2013

Neurotherapeutics

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Protein misfolding disorders, such as Alzheimer's disease and Parkinson's disease, have in common that a protein accumulates in an insoluble form in the affected tissue. The process of aggregation follows a mechanism of seeded polymerization. Although the toxic species is still not well defined, the process, rather than the end product, of fibril formation is likely the main culprit in amyloid toxicity. These findings suggest that therapeutic strategies directed against the protein misfolding cascade should focus on depleting aggregation intermediates rather than on large fibrillar aggregates. Recent studies involving natural compounds have suggested new intervention strategies. The polyphenol epi-gallocatechine-3-gallate (EGCG), the main polyphenol in Camilla sinensis, binds directly to a large number of proteins that are involved in protein misfolding diseases and inhibits their fibrillization. Instead, it promotes the formation of stable, spherical aggregates. These spherical aggregates are not cytotoxic, have a lower β-sheet content than fibrils, and do not catalyze fibril formation. Correspondingly, epi-gallocatechine-3-gallate remodels amyloid fibrils into aggregates with the same properties. Derivatives of Orcein, which is a phenoxazine dye that can be isolated from the lichen Roccella tinctoria, form a second promising class of natural compounds. They accelerate fibril formation of the Alzheimer's disease-related amyloid-beta peptide. At the same time these compounds deplete oligomeric and protofibrillar forms of the peptide. These compounds may serve as proof-of-principle for the strategies of promoting and redirecting fibril formation. Both may emerge as two promising new therapeutic approaches to intervening into protein misfolding processes.

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National Institute on Aging–Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease

Cited by 2,070 publications

References 104 publications

Clinicopathological and ¹²³I‐FP‐CIT SPECT correlations in patients with dementia

Clinicopathological and ¹²³I‐FP‐CIT SPECT correlations in patients with dementia

Alzheimer’s disease: A review of its visual system neuropathology. Optical coherence tomography—a potential role as a study tool in vivo

Natural Compounds May Open New Routes to Treatment of Amyloid Diseases

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National Institute on Aging–Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease

Cited by 2,070 publications

References 104 publications

Clinicopathological and 123I‐FP‐CIT SPECT correlations in patients with dementia

Clinicopathological and 123I‐FP‐CIT SPECT correlations in patients with dementia

Alzheimer’s disease: A review of its visual system neuropathology. Optical coherence tomography—a potential role as a study tool in vivo

Natural Compounds May Open New Routes to Treatment of Amyloid Diseases

Contact Info

Product

Resources

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Clinicopathological and ¹²³I‐FP‐CIT SPECT correlations in patients with dementia

Clinicopathological and ¹²³I‐FP‐CIT SPECT correlations in patients with dementia